Home >> Signaling Pathways >> Proteases >> Elastase


Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.

  1. Cat.No. 产品名称 Information
  2. GC61744 FK706
  3. GC60858 Freselestat quarterhydrate
  4. GC50225 ONO 6818 ONO 6818 (ONO-6818) 是一种有效且具有口服活性的中性粒细胞弹性蛋白酶抑制剂,Ki 为 12.2 nM。
  5. GC37618 Secologanoside
  6. GC35884 DMP 777
  7. GC35476 BAY-678 racemate
  8. GC32628 ZD-0892
  9. GC32016 AE-3763
  10. GC32005 ZD8321
  11. GC31564 BAY-85-8501
  12. GC31494 Lodelaben (SC-39026)
  13. GC12088 BAY-678 A selective, cell permeable inhibitor of human neutrophil elastase
  14. GC11847 (Z-Ala-Ala-Ala-Ala)2Rh110 A fluorogenic elastase substrate
  15. GC11981 Neutrophil Elastase Inhibitor A selective inhibitor of neutrophil elastase
  16. GC16724 Sivelestat (ONO-5046) Sivelestat (ONO-5046) (EI546) 是人中性粒细胞弹性蛋白酶的竞争性抑制剂,IC50 为 44 nM,Ki 为 200 nM。 Sivelestat (ONO-5046) (EI546) 具有研究 COVID-19 中急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的潜力。
  17. GC13851 GW311616 hydrochloride An inhibitor of neutrophil elastase
  18. GC11615 GW311616 GW-311616 是一种有效的、可口服的、长效的、选择性的人中性粒细胞弹性蛋白酶 (HNE) 抑制剂,IC50 值为 22 nM,Ki 值为 0.31 nM。
  19. GC14785 Alvelestat An inhibitor of neutrophil elastase
  20. GC10672 SSR 69071 A potent inhibitor of neutrophil elastase
  21. GC17247 Sivelestat sodium salt An inhibitor of neutrophil elastase
  22. GC13487 ARP 100 A selective inhibitor of MMP-2

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