Elastase(弹性蛋白酶)
Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.
- Cat.No. 产品名称 Information
-
GC61744
FK706
-
GC60858
Freselestat quarterhydrate
-
GC50225
ONO 6818
ONO 6818 (ONO-6818) 是一种有效且具有口服活性的中性粒细胞弹性蛋白酶抑制剂,Ki 为 12.2 nM。
-
GC37618
Secologanoside
-
GC35884
DMP 777
-
GC35476
BAY-678 racemate
-
GC32628
ZD-0892
-
GC32016
AE-3763
-
GC32005
ZD8321
-
GC31564
BAY-85-8501
-
GC31494
Lodelaben (SC-39026)
-
GC12088
BAY-678
A selective, cell permeable inhibitor of human neutrophil elastase
-
GC11847
(Z-Ala-Ala-Ala-Ala)2Rh110
A fluorogenic elastase substrate
-
GC11981
Neutrophil Elastase Inhibitor
A selective inhibitor of neutrophil elastase
-
GC16724
Sivelestat (ONO-5046)
Sivelestat (ONO-5046) (EI546) 是人中性粒细胞弹性蛋白酶的竞争性抑制剂,IC50 为 44 nM,Ki 为 200 nM。 Sivelestat (ONO-5046) (EI546) 具有研究 COVID-19 中急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的潜力。
-
GC13851
GW311616 hydrochloride
An inhibitor of neutrophil elastase
-
GC11615
GW311616
GW-311616 是一种有效的、可口服的、长效的、选择性的人中性粒细胞弹性蛋白酶 (HNE) 抑制剂,IC50 值为 22 nM,Ki 值为 0.31 nM。
-
GC14785
Alvelestat
An inhibitor of neutrophil elastase
-
GC10672
SSR 69071
A potent inhibitor of neutrophil elastase
-
GC17247
Sivelestat sodium salt
An inhibitor of neutrophil elastase
-
GC13487
ARP 100
A selective inhibitor of MMP-2