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Dipeptidyl Peptidase(二肽基肽酶)

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Products for  Dipeptidyl Peptidase

  1. Cat.No. 产品名称 Information
  2. GC69901 Sitagliptin fenilalanil hydrochloride Sitagliptin fenilalanil hydrochloride 是一种二肽氨基肽酶 (DPP-4) 抑制剂。
  3. GC69900 Sitagliptin fenilalanil Sitagliptin fenilalanil 是一种二肽氨基肽酶 (DPP-4) 抑制剂。
  4. GC68890 Cofrogliptin Cofrogliptin (HSK7653) (compound 2),一种四氢吡喃衍生物,是一种有效的口服 DPP-4 抑制剂,具有长效降糖作用。Cofrogliptin (compound 2) 在2型糖尿病 (T2DM) 应用中具有很大的潜力。
  5. GC66355 Linagliptin-d4 Linagliptin-d4 是 Linagliptin 氘代物。Linagliptin 是一种有效,选择性的 DPP-4 抑制剂,IC50 值为 1 nM。
  6. GC63383 Sitagliptin-d4 phosphate Sitagliptin-d4 (MK-0431-d4) phosphate 是 Sitagliptin phosphate 的氘代物。Sitagliptin phosphate (MK-0431 phosphate) 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞中,IC50 值为 19 nM。
  7. GC63170 Retagliptin Retagliptin (SP2086) 是一种选择性的竞争性,且具有口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin 可用于 2 型糖尿病 (T2DM) 的研究。
  8. GC62280 Teneligliptin D8 Teneligliptin D8 (MP-513 D8) 一种氘标记的 Teneligliptin (MP-513)。Teneligliptin D8 (MP-513 D8) 是一种强效的、口服的、有竞争力的、持久的 DPP-4 抑制剂。
  9. GC47751 Nateglinide-d5 An internal standard for the quantification of nateglinide
  10. GC60828 Evogliptin tartrate Evogliptintartrate是一种高效、口服有效、选择性的DPP-4抑制剂,具有抗糖尿病活性。Evogliptintartrate可用于靶向动脉炎症和动脉粥样硬化的研究。
  11. GC60613 Azaleatin

    Azaleatin是一种从Rhododendron种中分离得到的O-甲基化黄酮醇。Azaleatin是二肽基肽酶-IV的抑制剂。Azaleatin可用于2型糖尿病和肥胖症的研究。

  12. GC39296 1G244 1G244 是一种有效的 DPP8/9 抑制剂,IC50 分别为 12 nM 和 84 nM,但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡,并具有抗骨髓瘤作用。
  13. GC45436 Diprotin A A tripeptide inhibitor of DPP-4
  14. GC37757 Teneligliptin hydrobromide hydrate A DPP-4 inhibitor
  15. GC37594 Saxagliptin hydrate

    Saxagliptin H2O (BMS-477118, Onglyza) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

  16. GC44874 Saxagliptin (hydrochloride) A potent DPP-4 inhibitor
  17. GC44353 NDMC101 A salicylanilide derivative
  18. GC33853 Talabostat (PT100) Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities.
  19. GC33769 Gemigliptin (LC15-0444) Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
  20. GC32546 Prodipine hydrochloride Prodipine是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶IV(DPPIV),IC50分别为4.5μM和30μM。
  21. GC31547 DPP-IV-IN-1 DPP-IV-IN-1是一种有效的dipeptidylpeptidaseIV(DPP-IV)抑制剂,IC50值为4.6nM;DPP-IV为一种特异性的丝氨酸蛋白酶(serineprotease)。
  22. GC31492 Vildagliptin dihydrate (LAF237 dihydrate) A DPP-4 inhibitor
  23. GC31472 Retagliptin Phosphate (SP 2086) Retagliptin Phosphate (SP 2086) (SP2086 phosphate) 是一种选择性、竞争性和口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。
  24. GC31467 Dutogliptin Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。
  25. GC31463 Gosogliptin (PF-00734200)

    An inhibitor of DPP-4

  26. GC31444 Saikogenin A SaikogeninA可从中药柴胡中提取,是一种二肽基肽酶IV(DPP-IV)抑制剂。
  27. GC31414 Diprotin A TFA (Ile-Pro-Pro (TFA)) A tripeptide inhibitor of DPP-4
  28. GC31341 Anagliptin (SK-0403) A DPP-4 inhibitor
  29. GC31333 Teneligliptin (MP-513) Teneliligliptin (MP-513) (MP-513) 是一种有效的、可口服的、有竞争力的、长效的 DPP-4 抑制剂。
  30. GC31317 Sitagliptin (MK0431) Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.
  31. GC30877 DPP-IV-IN-2 DPP-IV-IN-2是二肽基肽酶IV(DPIV)和DP8/9的抑制剂,其IC50值分别为0.1和0.95μM。
  32. GC19120 DBPR108 DBPR108 是一种有效的、选择性的、口服生物可利用的二肽衍生的 DPP4 抑制剂,IC50 为 15 nM。对 DDP8 和 DPP9 无抑制作用。
  33. GC19052 AZD7986 An inhibitor of DPP-1
  34. GC12235 Sitagliptin (phosphate) A DPP-4 inhibitor
  35. GC17012 MK3102 MK3102 (Omarigliptin) is a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50: 2.
  36. GC12360 UAMC 00039 dihydrochloride A potent DPP-2 inhibitor
  37. GC10018 Talabostat mesylate

    塔拉司他Talabostat (PT100)是二肽基肽酶DPP的抑制剂,对DPP-IV、DPP8、DPP9、QPP、FAP和PEP的IC50值分别为<4 nM、4 nM、11 nM、310 nM、560 nM和390 nM。它具有抗肿瘤和刺激造血作用的活性。

  38. GC10091 Nateglinide A hypoglycemic agent
  39. GC12895 Saxagliptin A potent DPP-4 inhibitor
  40. GC17479 Trelagliptin succinate A DDP-4 inhibitor
  41. GC16613 Trelagliptin A DDP-4 inhibitor
  42. GC15576 Teneligliptin hydrobromide A DPP-4 inhibitor
  43. GC10171 Puromycin aminonucleoside

    A glomerular epithelial cell toxin

  44. GC13949 Alogliptin Benzoate A DPP-4 inhibitor
  45. GC15130 Alogliptin (SYR-322) Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂,IC50 <10 nM,选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.
  46. GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor
  47. GC10298 Sitagliptin phosphate monohydrate Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂,在 Caco-2 细胞提取物中的 IC50 为 19 nM。
  48. GC14827 Linagliptin (BI-1356) A potent DPP-4 inhibitor

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