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HIV Protease(HIV蛋白酶)

Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

  1. Cat.No. 产品名称 Information
  2. GC66400 Hinokinin
  3. GC65584 TMC310911
  4. GC65440 ddCTP trisodium
  5. GC64331 Ritonavir-13C,d3
  6. GC39068 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
  7. GC36872 Pepstatin Trifluoroacetate
  8. GC36871 Pepstatin Ammonium
  9. GC36333 Isoescin IA
  10. GC36310 Indinavir sulfate An HIV-1 protease inhibitor
  11. GC36309 Indinavir Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
  12. GC36120 Ganodermanondiol
  13. GC36116 Ganoderic acid B A triterpenoid with diverse biological activities
  14. GC43358 Cytochalasin A Inhibitor of actin polymerization
  15. GC33968 DPC-681 (DPH-153893)
  16. GC32327 PNU-103017
  17. GC32013 L-689502
  18. GC17942 Darunavir Ethanolate An HIV-1 protease inhibitor
  19. GC17709 Nelfinavir Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
  20. GC14454 Tipranavir A nonpeptidic HIV protease inhibitor
  21. GC15785 Saquinavir mesylate An HIV protease inhibitor
  22. GC15335 Saquinavir Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,用于抗逆转录病毒治疗。
  23. GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor
  24. GC11300 Fosamprenavir Calcium Salt A prodrug form of amprenavir
  25. GC10794 BMS-626529 An HIV-1 attachment inhibitor
  26. GC14152 Amprenavir (agenerase) A selective HIV protease inhibitor
  27. GC16602 Darunavir An HIV-1 protease inhibitor
  28. GC17303 Ritonavir An HIV protease inhibitor
  29. GC10240 Atazanavir sulfate (BMS-232632-05) An inhibitor of HIV-1 protease
  30. GC12945 Atazanavir An inhibitor of HIV-1 protease
  31. GN10545 Escin IA A triterpenoid saponin with diverse biological activities
  32. GC13716 Lopinavir A potent HIV-1 protease inhibitor
  33. GC11974 Pepstatin A A pentapeptide inhibitor of aspartic proteases

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