HIV Protease(HIV蛋白酶)
Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.
- Cat.No. 产品名称 Information
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GC66400
Hinokinin
Hinokinin (Compound 1) 是一种从Hypoestes aristate 茎中分离出来的化合物。Hinokinin 具有中等的 HIV-1 蛋白酶活性。
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GC65584
TMC310911
TMC310911 是一种有效且具有口服活性的 HIV-1 蛋白酶抑制剂,对于野生型 HIV-1,EC50 值范围为 2.2 nM 至 14.2 nM。TMC310911 对多种重组的 HIV-1 分离株也具有有效的活性,并具有很强的抗病毒活性。
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GC65440
ddCTP trisodium
ddCTP trisodium 是一类双脱氧核糖核苷酸 (ddNTPs),可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。ddCTP trisodium 是一种核苷类似物,靶向人类免疫缺陷病毒 (HIV) 的逆转录酶。ddCTP trisodium 可用于艾滋病 (AIDS) 研究。
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GC64331
Ritonavir-13C,d3
Ritonavir-13C,d3 (ABT 538-13C,d3) 是一种 13C- 和氘代标记的 Ritonavir。Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。Ritonavir 也是 SARS-CoV 3CLpro 的抑制剂,IC50 为 1.61 μM。
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GC39068
Rosamultin
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
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GC36872
Pepstatin Trifluoroacetate
Pepstatin Trifluoroacetate 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM。
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GC36871
Pepstatin Ammonium
Pepstatin Ammonium 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM;同时可抑制 HIV protease 的活性。
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GC36333
Isoescin IA
Isoescin IA 是一种从 Aesculus chinensis 种子中分离出的三萜皂苷。Isoescin IA 具有抗 HIV-1 蛋白酶活性。
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GC36310
Indinavir sulfate
An HIV-
1 protease inhibitor -
GC36309
Indinavir
Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
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GC36120
Ganodermanondiol
Ganodermanondiol 是从灵芝中分离出的一种促黑素生成抑制剂。Ganodermanondiol 对叔丁基过氧化氢诱导的肝毒性具有高效的细胞保护作用。Ganodermanondiol 具有抗 HIV-1 protease 活性,其 IC50 值为 90 μM。Ganodermanondiol 具有很强的抗补体活性,对经典补体途径作用的 IC50 值为 41.7 μM。
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GC36116
Ganoderic acid B
A triterpenoid with diverse biological activities
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GC43358
Cytochalasin A
Inhibitor of actin polymerization
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GC33968
DPC-681 (DPH-153893)
DPC-681 (DPH-153893) 是一种有效的选择性 HIV 蛋白酶抑制剂,对野生型 HIV-1 的 IC90 为 4 至 40 nM。
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GC32327
PNU-103017
PNU-103017是一种HIV蛋白酶抑制剂。
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GC32013
L-689502
L-689502是一个有效的HIV-1蛋白酶(HIV-lprotease)抑制剂,其IC50值为1nM。
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GC17942
Darunavir Ethanolate
An HIV-1 protease inhibitor
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GC17709
Nelfinavir
Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
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GC14454
Tipranavir
A nonpeptidic HIV protease inhibitor
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GC15785
Saquinavir mesylate
An HIV protease inhibitor
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GC15335
Saquinavir
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,用于抗逆转录病毒治疗。
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GC14084
Nelfinavir Mesylate
An HIV-1 protease inhibitor
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GC11300
Fosamprenavir Calcium Salt
A prodrug form of amprenavir
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GC10794
BMS-626529
An HIV-1 attachment inhibitor
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GC14152
Amprenavir (agenerase)
A selective HIV protease inhibitor
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GC16602
Darunavir
An HIV-1 protease inhibitor
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GC17303
Ritonavir
An HIV protease inhibitor
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GC10240
Atazanavir sulfate (BMS-232632-05)
An inhibitor of HIV-1 protease
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GC12945
Atazanavir
An inhibitor of HIV-1 protease
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GN10545
Escin IA
A triterpenoid saponin with diverse biological activities
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GC13716
Lopinavir
A potent HIV-1 protease inhibitor
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GC11974
Pepstatin A
Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.