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HIV Protease(HIV蛋白酶)

Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

  1. Cat.No. 产品名称 Information
  2. GC66400 Hinokinin Hinokinin (Compound 1) 是一种从Hypoestes aristate 茎中分离出来的化合物。Hinokinin 具有中等的 HIV-1 蛋白酶活性。
  3. GC65584 TMC310911 TMC310911 是一种有效且具有口服活性的 HIV-1 蛋白酶抑制剂,对于野生型 HIV-1,EC50 值范围为 2.2 nM 至 14.2 nM。TMC310911 对多种重组的 HIV-1 分离株也具有有效的活性,并具有很强的抗病毒活性。
  4. GC65440 ddCTP trisodium ddCTP trisodium 是一类双脱氧核糖核苷酸 (ddNTPs),可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。ddCTP trisodium 是一种核苷类似物,靶向人类免疫缺陷病毒 (HIV) 的逆转录酶。ddCTP trisodium 可用于艾滋病 (AIDS) 研究。
  5. GC64331 Ritonavir-13C,d3 Ritonavir-13C,d3 (ABT 538-13C,d3) 是一种 13C- 和氘代标记的 Ritonavir。Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。Ritonavir 也是 SARS-CoV 3CLpro 的抑制剂,IC50 为 1.61 μM。
  6. GC39068 Rosamultin Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
  7. GC36872 Pepstatin Trifluoroacetate Pepstatin Trifluoroacetate 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM。
  8. GC36871 Pepstatin Ammonium Pepstatin Ammonium 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM;同时可抑制 HIV protease 的活性。
  9. GC36333 Isoescin IA Isoescin IA 是一种从 Aesculus chinensis 种子中分离出的三萜皂苷。Isoescin IA 具有抗 HIV-1 蛋白酶活性。
  10. GC36310 Indinavir sulfate An HIV-1 protease inhibitor
  11. GC36309 Indinavir Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
  12. GC36120 Ganodermanondiol Ganodermanondiol 是从灵芝中分离出的一种促黑素生成抑制剂。Ganodermanondiol 对叔丁基过氧化氢诱导的肝毒性具有高效的细胞保护作用。Ganodermanondiol 具有抗 HIV-1 protease 活性,其 IC50 值为 90 μM。Ganodermanondiol 具有很强的抗补体活性,对经典补体途径作用的 IC50 值为 41.7 μM。
  13. GC36116 Ganoderic acid B A triterpenoid with diverse biological activities
  14. GC43358 Cytochalasin A Inhibitor of actin polymerization
  15. GC33968 DPC-681 (DPH-153893) DPC-681 (DPH-153893) 是一种有效的选择性 HIV 蛋白酶抑制剂,对野生型 HIV-1 的 IC90 为 4 至 40 nM。
  16. GC32327 PNU-103017 PNU-103017是一种HIV蛋白酶抑制剂。
  17. GC32013 L-689502

    L-689502是一个有效的HIV-1蛋白酶(HIV-lprotease)抑制剂,其IC50值为1nM。

  18. GC17942 Darunavir Ethanolate An HIV-1 protease inhibitor
  19. GC17709 Nelfinavir Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
  20. GC14454 Tipranavir A nonpeptidic HIV protease inhibitor
  21. GC15785 Saquinavir mesylate An HIV protease inhibitor
  22. GC15335 Saquinavir Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,用于抗逆转录病毒治疗。
  23. GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor
  24. GC11300 Fosamprenavir Calcium Salt A prodrug form of amprenavir
  25. GC10794 BMS-626529 An HIV-1 attachment inhibitor
  26. GC14152 Amprenavir (agenerase) A selective HIV protease inhibitor
  27. GC16602 Darunavir An HIV-1 protease inhibitor
  28. GC17303 Ritonavir An HIV protease inhibitor
  29. GC10240 Atazanavir sulfate (BMS-232632-05) An inhibitor of HIV-1 protease
  30. GC12945 Atazanavir

    An inhibitor of HIV-1 protease

  31. GN10545 Escin IA A triterpenoid saponin with diverse biological activities
  32. GC13716 Lopinavir A potent HIV-1 protease inhibitor
  33. GC11974 Pepstatin A

    Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.

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