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HIV Protease(HIV蛋白酶)

Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products for  HIV Protease

  1. Cat.No. 产品名称 Information
  2. GC66400 Hinokinin


    Hinokinin (Compound 1) 是一种从Hypoestes aristate 茎中分离出来的化合物。Hinokinin 具有中等的 HIV-1 蛋白酶活性。
  3. GC65584 TMC310911


    TMC310911 是一种有效且具有口服活性的 HIV-1 蛋白酶抑制剂,对于野生型 HIV-1,EC50 值范围为 2.2 nM 至 14.2 nM。TMC310911 对多种重组的 HIV-1 分离株也具有有效的活性,并具有很强的抗病毒活性。
  4. GC65440 ddCTP trisodium ddCTP trisodium 是一类双脱氧核糖核苷酸 (ddNTPs),可作为 DNA 聚合酶链延长抑制剂用于 DNA 测序。ddCTP trisodium 是一种核苷类似物,靶向人类免疫缺陷病毒 (HIV) 的逆转录酶。ddCTP trisodium 可用于艾滋病 (AIDS) 研究。
  5. GC64331 Ritonavir-13C,d3

    ABT 538-13C,d3; RTV-13C,d3

    Ritonavir-13C,d3 (ABT 538-13C,d3) 是一种 13C- 和氘代标记的 Ritonavir。Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。Ritonavir 也是 SARS-CoV 3CLpro 的抑制剂,IC50 为 1.61 μM。
  6. GC39068 Rosamultin


    Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
  7. GC36872 Pepstatin Trifluoroacetate

    抑肽素三氟醋酸盐; Pepstatin A Trifluoroacetate

    Pepstatin Trifluoroacetate 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM。
  8. GC36871 Pepstatin Ammonium

    Pepstatin A Ammonium

    Pepstatin Ammonium 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM;同时可抑制 HIV protease 的活性。
  9. GC36333 Isoescin IA


    Isoescin IA 是一种从 Aesculus chinensis 种子中分离出的三萜皂苷。Isoescin IA 具有抗 HIV-1 蛋白酶活性。
  10. GC36310 Indinavir sulfate

    硫酸茚地那韦; MK-639; L735524

    An HIV-1 protease inhibitor
  11. GC36309 Indinavir

    茚地那韦; MK-639 free base; L-735524 free base

    Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
  12. GC36120 Ganodermanondiol


    Ganodermanondiol 是从灵芝中分离出的一种促黑素生成抑制剂。Ganodermanondiol 对叔丁基过氧化氢诱导的肝毒性具有高效的细胞保护作用。Ganodermanondiol 具有抗 HIV-1 protease 活性,其 IC50 值为 90 μM。Ganodermanondiol 具有很强的抗补体活性,对经典补体途径作用的 IC50 值为 41.7 μM。
  13. GC36116 Ganoderic acid B


    A triterpenoid with diverse biological activities
  14. GC43358 Cytochalasin A


    Inhibitor of actin polymerization
  15. GC33968 DPC-681 (DPH-153893)


    DPC-681 (DPH-153893) 是一种有效的选择性 HIV 蛋白酶抑制剂,对野生型 HIV-1 的 IC90 为 4 至 40 nM。
  16. GC32327 PNU-103017 PNU-103017是一种HIV蛋白酶抑制剂。
  17. GC32013 L-689502


  18. GC17942 Darunavir Ethanolate

    达芦那韦乙醇; TMC114 Ethanolate

    An HIV-1 protease inhibitor
  19. GC17709 Nelfinavir


    Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
  20. GC14454 Tipranavir


    A nonpeptidic HIV protease inhibitor
  21. GC15785 Saquinavir mesylate

    沙奎那韦甲磺酸盐; Ro 31-8959/003

    An HIV protease inhibitor
  22. GC15335 Saquinavir

    沙奎那韦; Ro 31-8959

    Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,用于抗逆转录病毒治疗。
  23. GC14084 Nelfinavir Mesylate

    甲磺酸奈非那韦,AG 1343 Mesylate;AG1343 Mesylate;AG-1343 Mesylate,Nelfinavir

    An HIV-1 protease inhibitor
  24. GC11300 Fosamprenavir Calcium Salt

    福沙那伟钙,GW 433908G;Lexiva;GW433908G;GW-433908G

    A prodrug form of amprenavir
  25. GC10794 BMS-626529

    1-(4-苯甲酰基哌嗪-1-基)-2-[4-甲氧基-7-(3-甲基-1H-1,2,4-三氮唑-1-基)-1H-吡咯并[2,3-C]吡啶-3-基)乙烷-1,2-二酮,BMS 626529;BMS626529

    An HIV-1 attachment inhibitor
  26. GC14152 Amprenavir (agenerase)

    安瑞那韦; VX-478

    A selective HIV protease inhibitor
  27. GC16602 Darunavir

    达芦那韦; TMC114; UIC-94017

    An HIV-1 protease inhibitor
  28. GC17303 Ritonavir

    利托那韦; ABT 538; RTV

    An HIV protease inhibitor
  29. GC10240 Atazanavir sulfate (BMS-232632-05)

    硫酸阿扎那韦; BMS-232632 sulfate

    An inhibitor of HIV-1 protease
  30. GC12945 Atazanavir

    阿扎那韦; BMS-232632

    An inhibitor of HIV-1 protease

  31. GN10545 Escin IA


    A triterpenoid saponin with diverse biological activities
  32. GC13716 Lopinavir

    洛匹那韦; ABT-378

    A potent HIV-1 protease inhibitor
  33. GC11974 Pepstatin A

    抑肽素; Pepstatin A

    Pepstatin A is an orally active inhibitor of aspartic proteases, which is produced by actinomycetes.

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