HIV Protease(HIV蛋白酶)
Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.
- Cat.No. 产品名称 Information
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GC66400
Hinokinin
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GC65584
TMC310911
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GC65440
ddCTP trisodium
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GC64331
Ritonavir-13C,d3
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GC39068
Rosamultin
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina L. that inhibits HIV-1 protease. Rosamultin has protective effects on H2O2-induced oxidative damage and apoptosis.
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GC36872
Pepstatin Trifluoroacetate
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GC36871
Pepstatin Ammonium
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GC36333
Isoescin IA
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GC36310
Indinavir sulfate
An HIV-
1 protease inhibitor -
GC36309
Indinavir
Indinavir sulfate (Crixivan, L-735524, MK-639) is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS.
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GC36120
Ganodermanondiol
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GC36116
Ganoderic acid B
A triterpenoid with diverse biological activities
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GC43358
Cytochalasin A
Inhibitor of actin polymerization
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GC33968
DPC-681 (DPH-153893)
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GC32327
PNU-103017
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GC32013
L-689502
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GC17942
Darunavir Ethanolate
An HIV-1 protease inhibitor
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GC17709
Nelfinavir
Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
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GC14454
Tipranavir
A nonpeptidic HIV protease inhibitor
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GC15785
Saquinavir mesylate
An HIV protease inhibitor
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GC15335
Saquinavir
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,用于抗逆转录病毒治疗。
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GC14084
Nelfinavir Mesylate
An HIV-1 protease inhibitor
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GC11300
Fosamprenavir Calcium Salt
A prodrug form of amprenavir
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GC10794
BMS-626529
An HIV-1 attachment inhibitor
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GC14152
Amprenavir (agenerase)
A selective HIV protease inhibitor
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GC16602
Darunavir
An HIV-1 protease inhibitor
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GC17303
Ritonavir
An HIV protease inhibitor
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GC10240
Atazanavir sulfate (BMS-232632-05)
An inhibitor of HIV-1 protease
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GC12945
Atazanavir
An inhibitor of HIV-1 protease
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GN10545
Escin IA
A triterpenoid saponin with diverse biological activities
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GC13716
Lopinavir
A potent HIV-1 protease inhibitor
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GC11974
Pepstatin A
A pentapeptide inhibitor of aspartic proteases