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Home >> Signaling Pathways >> Proteases >> HCV Protease

HCV Protease(HCV蛋白酶)

Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

  1. Cat.No. 产品名称 Information
  2. GC25117 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
  3. GC68453 ITMN 4077
  4. GC65345 BI 653048
  5. GC64066 Coblopasvir dihydrochloride A pan-genotypic inhibitor of HCV NS5A
  6. GC64065 Coblopasvir A pan-genotypic inhibitor of HCV NS5A
  7. GC64038 Simeprevir-13C,d3
  8. GC64016 Samatasvir An HCV NS5A inhibitor
  9. GC60947 Isoeuphorbetin
  10. GC37921 Voxilaprevir A pan-genotypic HCV NS3/4A protease inhibitor
  11. GC32305 ACH-806 (GS9132)
  12. GC19165 Glecaprevir An HCV NS3/4A protease inhibitor
  13. GC13312 HZ-1157 An HCV NS3/4A protease and Dengue virus inhibitor
  14. GC12057 Daclatasvir (BMS-790052) An NS5A inhibitor
  15. GC10155 Vaniprevir Vaniprevir (MK-7009) 是丙型肝炎病毒 (HCV) NS3/4A 蛋白酶的非共价竞争性抑制剂。
  16. GC16887 Tegobuvir A non-nucleoside inhibitor of HCV NS5B
  17. GC17270 Simeprevir A potent NS3/4A protease inhibitor
  18. GC15891 Nesbuvir Nesbuvir 是丙型肝炎病毒 (HCV) 非结构蛋白 5B (NS5B) 聚合酶的非核苷抑制剂。
  19. GC14074 Narlaprevir Narlaprevir (SCH 900518) 是一种选择性和口服生物可利用的 NS3 蛋白酶抑制剂，Ki 值为 6 nM，EC90 值为 40 nM。
  20. GC11463 MK-5172 sodium salt MK-5172 sodium salt (MK-5172 sodium salt) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，对基因型和耐药变异具有广泛的活性，Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
  21. GC17114 MK-5172 potassium salt MK-5172钾盐（MK-5172钾盐）是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂，具有跨基因型和耐药变体的广泛活性，Kis为0.01 nM（gt1b），0.01 nM（gt1a），0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
  22. GC16098 MK-5172 hydrate MK-5172 hydrate (MK-5172 hydrate) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，对基因型和耐药变体具有广泛的活性，Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a) )、0.15 nM (gt2b)、0.90 nM (gt3a)。
  23. GC18004 MK-5172 An NS3/4A protease inhibitor
  24. GC17701 Clemizole hydrochloride An antihistamine and TRPC5 channel blocker
  25. GC12444 Clemizole An antihistamine and TRPC5 channel blocker
  26. GC10959 Boceprevir An NS3/4A protease inhibitor
  27. GC12236 Daclatasvir dihydrochloride An NS5A inhibitor
  28. GC10930 Balapiravir Balapiravir (Ro 4588161; R1626) 是 HCV (R1479; 4'-Azidocytidine) 的 RNA 依赖性 RNA 聚合酶 (RdRp) 的核苷类似物抑制剂的口服活性前药。
  29. GC14458 Asunaprevir (BMS-650032) An HCV NS3/4A protease inhibitor
  30. GC14937 Anguizole Anguizole 是一种 HCV 复制的小分子抑制剂，可改变 NS4B 的亚细胞分布。
  31. GC10832 VX-222 (VCH-222, Lomibuvir) An HCV polymerase inhibitor
  32. GC12299 Telaprevir (VX-950) An HCV NS3/4A protease inhibitor
  33. GC12879 Danoprevir (RG7227) An HCV NS3/4A protease inhibitor
  34. GC16901 PSI-6206 An inactive derivative of a HCV NS5B inhibitor

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