Gamma Secretase(伽玛分泌酶)
Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.
- Cat.No. 产品名称 Information
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GC67476
(E/Z)-Sulindac sulfide
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GC63407
PF-06648671
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GC63366
Fosciclopirox
Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2. It is used in the treatment of urothelial cancer and a number of solid and hematologic malignancies.
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GC62998
GSM-1
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GC62859
Aβ42-IN-2
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GC50251
PF 3084014 hydrobromide
An inhibitor of γ-secretase
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GC38782
gamma-secretase modulator 1 hydrochloride
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GC38011
γ-Secretase modulator 4
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GC36514
LY-411575 isomer 3
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GC36513
LY-411575 isomer 2
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GC36512
LY-411575 isomer 1
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GC36109
gamma-secretase modulator 3
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GC36108
gamma-secretase modulator 2
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GC36107
gamma-secretase modulator 1
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GC35921
E 2012
A γ-secretase modulator
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GC35535
BMS-906024
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GC33118
Compound E
An inhibitor of γ-
secretase -
GC31012
BMS 433796
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GC30954
Itanapraced (CHF5074)
A modulator of γ-secretase
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GC30887
NGP555
A γ-secretase modulator
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GC30427
ELN 318463 racemate
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GC19290
PF-3084014
An inhibitor of γ-secretase
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GC15059
Sulindac sulfide
An active metabolite of sulindac
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GC15896
Z-Ile-Leu-aldehyde
Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。
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GC16434
TC-E 5006
γ-secretase modulator
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GC12659
Begacestat
An inhibitor of γ-secretase
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GC10064
Flurizan
A COX-inactive enantiomer of flurbiprofen
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GC16431
MRK 560
A potent inhibitor of γ-secretase
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GC15364
L-685,458
A γ-secretase inhibitor
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GC13619
JLK 6
A protease inhibitor
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GC15645
Compound W
A Notch1 signaling modulator
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GC13099
BMS 299897
A γ-secretase inhibitor
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GC10998
PF-03084014
γ-secretase inhibitor
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GC12653
LY3039478
A Notch inhibitor
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GC13673
BMS-708163 (Avagacestat)
A potent inhibitor of γ-secretase
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GC17791
LY2811376
A BACE1 inhibitor
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GC12191
LY-411575
A γ-secretase inhibitor
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GC17671
YO-01027 (Dibenzazepine, DBZ)
An inhibitor of γ-secretase
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GC15899
MK-0752
A potent inhibitor of γ-secretase
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GC16197
RO4929097
An inhibitor of γ-secretase
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GC12942
DAPT (GSI-IX)
Inhibitor of γ-secretase
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GC12096
Semagacestat (LY450139)
A pan γ-secretase inhibitor