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Gamma Secretase(伽玛分泌酶)

Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

  1. Cat.No. 产品名称 Information
  2. GC67476 (E/Z)-Sulindac sulfide
  3. GC63407 PF-06648671
  4. GC63366 Fosciclopirox Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2. It is used in the treatment of urothelial cancer and a number of solid and hematologic malignancies.
  5. GC62998 GSM-1
  6. GC62859 Aβ42-IN-2
  7. GC50251 PF 3084014 hydrobromide An inhibitor of γ-secretase
  8. GC38782 gamma-secretase modulator 1 hydrochloride
  9. GC38011 γ-Secretase modulator 4
  10. GC36514 LY-411575 isomer 3
  11. GC36513 LY-411575 isomer 2
  12. GC36512 LY-411575 isomer 1
  13. GC36109 gamma-secretase modulator 3
  14. GC36108 gamma-secretase modulator 2
  15. GC36107 gamma-secretase modulator 1
  16. GC35921 E 2012 A γ-secretase modulator
  17. GC35535 BMS-906024
  18. GC33118 Compound E An inhibitor of γ-secretase
  19. GC31012 BMS 433796
  20. GC30954 Itanapraced (CHF5074) A modulator of γ-secretase
  21. GC30887 NGP555 A γ-secretase modulator
  22. GC30427 ELN 318463 racemate
  23. GC19290 PF-3084014 An inhibitor of γ-secretase
  24. GC15059 Sulindac sulfide An active metabolite of sulindac
  25. GC15896 Z-Ile-Leu-aldehyde Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。
  26. GC16434 TC-E 5006 γ-secretase modulator
  27. GC12659 Begacestat An inhibitor of γ-secretase
  28. GC10064 Flurizan A COX-inactive enantiomer of flurbiprofen
  29. GC16431 MRK 560 A potent inhibitor of γ-secretase
  30. GC15364 L-685,458 A γ-secretase inhibitor
  31. GC13619 JLK 6 A protease inhibitor
  32. GC15645 Compound W A Notch1 signaling modulator
  33. GC13099 BMS 299897 A γ-secretase inhibitor
  34. GC10998 PF-03084014

    γ-secretase inhibitor

  35. GC12653 LY3039478 A Notch inhibitor
  36. GC13673 BMS-708163 (Avagacestat) A potent inhibitor of γ-secretase
  37. GC17791 LY2811376 A BACE1 inhibitor
  38. GC12191 LY-411575 A γ-secretase inhibitor
  39. GC17671 YO-01027 (Dibenzazepine, DBZ) An inhibitor of γ-secretase
  40. GC15899 MK-0752 A potent inhibitor of γ-secretase
  41. GC16197 RO4929097

    An inhibitor of γ-secretase

  42. GC12942 DAPT (GSI-IX) Inhibitor of γ-secretase
  43. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor

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