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NS3/4a protease(NS3/4a 蛋白酶)

The NS3/4A serine protease is one of the hepatitis C virus proteases involved in the viral replication that catalyzes the cleavage of HCV polyprotein precursor encoded by HCV genome into fully functional virion. A mature HCV virion consists of at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The NS3/4A serine protease is a non-covalent heterodimer complex characterized by two domains, including the N-terminal serine protease domain of NS3 (catalytic subunit) and the NS4A cofactor (activation subunit) that cleaves the HCV polyprotein precursor at four junctions, including NS3/NS4A, NS4A/NS4B, NS4B/NS5A and NS5A/NS5B.

Products for  NS3/4a protease

  1. Cat.No. 产品名称 Information
  2. GC11463 MK-5172 sodium salt MK-5172 sodium salt (MK-5172 sodium salt) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂,对基因型和耐药变异具有广泛的活性,Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
  3. GC17114 MK-5172 potassium salt MK-5172钾盐(MK-5172钾盐)是丙型肝炎病毒NS3/4a蛋白酶的选择性抑制剂,具有跨基因型和耐药变体的广泛活性,Kis为0.01 nM(gt1b),0.01 nM(gt1a),0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
  4. GC16098 MK-5172 hydrate MK-5172 hydrate (MK-5172 hydrate) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂,对基因型和耐药变体具有广泛的活性,Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a) )、0.15 nM (gt2b)、0.90 nM (gt3a)。
  5. GC18004 MK-5172 An NS3/4A protease inhibitor

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