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HIV Integrase(HIV整合酶)

Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.

  1. Cat.No. 产品名称 Information
  2. GC68478 Bictegravir sodium
  3. GC67697 XZ426
  4. GC63399 HIV-1 integrase inhibitor 8
  5. GC61576 Robinetin A flavonol with diverse biological activities
  6. GC60978 L-Chicoric Acid A dicaffeoyl ester with diverse biological activities
  7. GC45494 Lavendustin B An inhibitor of Glut1
  8. GC36235 HIV-1 integrase inhibitor 4
  9. GC36234 HIV-1 integrase inhibitor 3
  10. GC36233 HIV-1 integrase inhibitor 2
  11. GC35510 BI 224436
  12. GC34961 (±)-BI-D
  13. GC32060 Bictegravir (GS-9883) An HIV-1 integrase inhibitor
  14. GC10572 Equisetin An HIV-1 integrase inhibitor
  15. GC14057 GSK1349572 sodiuM salt GSK1349572 sodiuM salt (S/GSK1349572 sodium) 是一种高效的口服生物可利用的 HIV 整合酶链转移抑制剂,对 HIV-1 整合酶催化的链转移的 IC50 为 2.7 nM。
  16. GC15036 Raltegravir potassium salt An HIV-1 integrase inhibitor
  17. GC18016 Salicylanilide Salicylanilide 具有广泛的生物活性,包括抗病毒效力,可通过靶向 HIV-1 整合酶或逆转录酶来抑制 HIV 病毒。
  18. GC17709 Nelfinavir Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
  19. GC16215 GSK744 (S/GSK1265744) An HIV-1 integrase inhibitor
  20. GC12339 Ivermectin A mixture of ivermectin B1a and ivermectin B1b
  21. GC14084 Nelfinavir Mesylate An HIV-1 protease inhibitor
  22. GC12998 HIV-1 integrase inhibitor HIV-1整合酶抑制剂可用于抗HIV。
  23. GC17906 S/GSK1349572 A potent inhibitor of HIV integrase
  24. GC11956 Raltegravir (MK-0518) Raltegravir (MK-0518) 是一种有效的整合酶 (IN) 抑制剂,用于治疗 HIV 感染。
  25. GC15561 MK-2048 MK-2048 是一种有效的整合酶和 INR263K 抑制剂,IC50 分别为 2.6 nM 和 1.5 nM。
  26. GC14466 Fluorouracil (Adrucil) A prodrug form of FdUMP
  27. GC14996 Elvitegravir (GS-9137) An inhibitor of HIV-1 integrase
  28. GC11923 BMS-707035 BMS-707035 是一种有效的口服活性 HIV-1 整合酶链转移抑制剂 (INSTI)。

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