HIV Integrase(HIV整合酶)
Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.
- Cat.No. 产品名称 Information
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GC68478
Bictegravir sodium
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GC67697
XZ426
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GC63399
HIV-1 integrase inhibitor 8
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GC61576
Robinetin
A flavonol with diverse biological activities
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GC60978
L-Chicoric Acid
A dicaffeoyl ester with diverse biological activities
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GC45494
Lavendustin B
An inhibitor of Glut1
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GC36235
HIV-1 integrase inhibitor 4
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GC36234
HIV-1 integrase inhibitor 3
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GC36233
HIV-1 integrase inhibitor 2
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GC35510
BI 224436
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GC34961
(±)-BI-D
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GC32060
Bictegravir (GS-9883)
An HIV-1 integrase inhibitor
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GC10572
Equisetin
An HIV-1 integrase inhibitor
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GC14057
GSK1349572 sodiuM salt
GSK1349572 sodiuM salt (S/GSK1349572 sodium) 是一种高效的口服生物可利用的 HIV 整合酶链转移抑制剂,对 HIV-1 整合酶催化的链转移的 IC50 为 2.7 nM。
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GC15036
Raltegravir potassium salt
An HIV-1 integrase inhibitor
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GC18016
Salicylanilide
Salicylanilide 具有广泛的生物活性,包括抗病毒效力,可通过靶向 HIV-1 整合酶或逆转录酶来抑制 HIV 病毒。
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GC17709
Nelfinavir
Nelfinavir Mesylate 是强效的HIV protease抑制剂,Ki为2 nM。
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GC16215
GSK744 (S/GSK1265744)
An HIV-1 integrase inhibitor
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GC12339
Ivermectin
A mixture of ivermectin B1a and ivermectin B1b
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GC14084
Nelfinavir Mesylate
An HIV-1 protease inhibitor
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GC12998
HIV-1 integrase inhibitor
HIV-1整合酶抑制剂可用于抗HIV。
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GC17906
S/GSK1349572
A potent inhibitor of HIV integrase
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GC11956
Raltegravir (MK-0518)
Raltegravir (MK-0518) 是一种有效的整合酶 (IN) 抑制剂,用于治疗 HIV 感染。
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GC15561
MK-2048
MK-2048 是一种有效的整合酶和 INR263K 抑制剂,IC50 分别为 2.6 nM 和 1.5 nM。
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GC14466
Fluorouracil (Adrucil)
A prodrug form of FdUMP
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GC14996
Elvitegravir (GS-9137)
An inhibitor of HIV-1 integrase
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GC11923
BMS-707035
BMS-707035 是一种有效的口服活性 HIV-1 整合酶链转移抑制剂 (INSTI)。