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Home >> Signaling Pathways >> Proteases >> Drug Metabolite

Drug Metabolite(药物代谢物)

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products for  Drug Metabolite

  1. Cat.No. 产品名称 Information
  2. GC69835 RPR132595A hydrochloride RPR132595A (NPC) hydrochloride 是 CPT-11 的活性代谢产物，它是由细胞色素 P-450 3A4 (CYP3A4) 产生并最终通过尿排出。
  3. GC69607 O-Demethyl Lenvatinib hydrochloride O-Demethyl Lenvatinib hydrochloride 是 Lenvatinib 的代谢物。Lenvatinib (E7080) 一种具有口服活性的，多靶点酪氨酸激酶抑制剂，VEGFR1-3、FGFR1-4、PDGFR、KIT 和 RET。Lenvatinib 显示有效抗癌的活性。
  4. GC69098 Febuxostat impurity 7 Febuxostat impurity 7 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
  5. GC68509 (25R)-12α-Hydroxyspirost-4-en-3-one (25R)-12α-Hydroxyspirost-4-en-3-one 是由 Nocardia globerula 作用于 Hecogenin 产生的一种次要代谢物。
  6. GC68387 FGN849

    FGN849 是 IMGN632 的活性有效载荷分解物。
  7. GC68324 3-Methoxytyramine-d4 hydrochloride 3-Methoxytyramine-d4 (3-O-methyl Dopamine-d4) hydrochloride 是 3-Methoxytyramine hydrochloride 的氘代物。3-Methoxytyramine hydrochloride 是多巴胺的无活性代谢物，可以活化痕量胺相关受体1 (TAAR1)。
  8. GC68082 3,4,5-Trimethoxyphenylacetic acid 3,4,5-Trimethoxyphenylacetic acid 是 Mescaline 的代谢物。
  9. GC67988 6-Hydroxybenzbromarone

    6-Hydroxybenzbromarone 是 Benzbromarone 的主要代谢产物 (metabolite)，比母体化合物具有更长的半衰期和更大的药理效力。6-Hydroxybenzbromarone 是一种 EYA3 抑制剂，IC50 值为 21.5 μM。6-Hydroxybenzbromarone 是一种血管生成剂，对细胞迁移，肾小管生成和血管生成具有强大的抑制作用。
  10. GC67902 3-Amino-2-oxazolidinone-d4 3-Amino-2-oxazolidinone-d4 是 3-Amino-2-oxazolidinone 的氘代物。3-Amino-2-oxazolidinone (AOZ) 是呋喃唑烷酮 的代谢物 (metabolite)。3-Amino-2-oxazolidinone 作为检测呋喃唑烷酮残留的一个指标。
  11. GC67766 Abiraterone sulfate Abiraterone sulfate 是 Abiraterone 的代谢物。Abiraterone 是一种不可逆的 CYP17A1 抑制剂，具有抗雄激素活性。
  12. GC67761 (Z)-10-Hydroxynortriptyline-d3 (Z)-10-Hydroxynortriptyline-d3 是 (Z)-10-Hydroxynortriptyline 的氘代物。(Z)-10-Hydroxynortriptyline 是 Nortriptyline 的代谢物。Nortriptyline 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢物，用于缓解抑郁症状。
  13. GC52478 Telmisartan Acyl-β-D-Glucuronide (hydrate) A major metabolite of telmisartan
  14. GC52368 DL-Sulforaphane Glutathione A metabolite of sulforaphane
  15. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
  16. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
  17. GC66449 Ferulic acid 4-O-sulfate Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) 是 Ferulic acid 的代谢物。Ferulic acid 4-O-sulfate 可以放松小鼠的动脉，降低血压。$
  18. GC66063 Tulipalin A 2-Methylenebutyrolactone (Tulipalin A, MBL, α-methylene-γ-butyrolactone), also known as α-methylene-γ-butyrolactone (MBL) (Tulipalin A), belongs to the class of sesquiterpene lactone family and is considered as cyclic analog of most common vinyl monomer methyl methacrylate (MMA).
  19. GC66057 10,11-Dihydrocarbamazepine 10,11-二氢卡马西平（10,11-Dihydrocarbamazepine）用作液相色谱法同时测定血浆中卡马西平及其活性代谢物的内标。可用于化学发光法测定卡马西平的含量。
  20. GC65956 Edoxaban M4 Edoxaban M4 是 Edoxaban 的活性代谢物，具有可重复性的、浓度依赖性的基质效应。Edoxaban (DU-176) 是选择性的、有效和口服活性的 factor Xa (FXa) 抑制剂。
  21. GC52177 Perphenazine Sulfoxide An active metabolite of perphenazine
  22. GC52173 N-desmethyl-Doxylamine (succinate) A metabolite of doxylamine
  23. GC52168 Aripiprazole N,N-dioxide A metabolite of aripiprazole
  24. GC52132 N-desmethyl Diltiazem (hydrochloride) An active metabolite of diltiazem
  25. GC65324 RP101988 RP101442 是 Ozanimod 的主要的活性代谢物，是一种选择性强的 S1PR1 激动剂，对 S1PR1 和 S1P5R 的 EC50 分别为 0.19 nM 和 32.8 nM。
  26. GC65142 Testosterone sulfate (pyridinium) Testosterone sulfate pyridinium 是一种含吡啶的硫酸睾酮。Testosterone sulfate 是睾酮的代谢产物。Testosterone 是主要的男性性激素，其测定有助于评估雄激素状态。
  27. GC64759 Dimethadione 5,5-Dimethyloxazolidine-2,4-dione (Dimethadione, Dimethyloxazolidinedione, Dimethadion) is an anticonvulsant that is the active metabolite of trimethadione.
  28. GC64720 Imipramine N-oxide Imipramine N-oxide 是 Imipramine 的代谢物。Imipramine 是一种叔胺三环类抗抑郁药。
  29. GC64511 Hydroxy ritonavir Hydroxy ritonavir 是 Ritonavir 的代谢物。Ritonavir 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。
  30. GC64469 Ribavirin carboxylic acid Ribavirin carboxylic acid (TR-COOH) 是一种 ribavirin 的代谢物 (metabolite)，ribavirin 具有强烈的抗病毒活性。
  31. GC52076 Temozolomide Acid An active metabolite of temozolomide
  32. GC52074 Loratadine N-oxide A metabolite of loratadine
  33. GC52060 Trimipramine N-oxide An active metabolite of trimipramine
  34. GC52059 AMOZ A metabolite of furaltadone
  35. GC52054 Ranitidine S-oxide A metabolite of ranitidine
  36. GC52052 Dofetilide N-oxide A metabolite of dofetilide
  37. GC52045 N-desmethyl Azelastine An active metabolite of azelastine
  38. GC52035 Esmolol Acid (hydrochloride) An active metabolite of esmolol
  39. GC52033 S-Methyl-D-penicillamine A metabolite of D-penicillamine
  40. GC52029 2-Aminoflubendazole A metabolite of flubendazole
  41. GC52024 Aripiprazole N-oxide A metabolite of aripiprazole
  42. GC52019 Norpropranolol (hydrochloride) An active metabolite of propranolol
  43. GC52007 N-hydroxylamine Dapsone An active metabolite of dapsone
  44. GC52005 Triazolomethylindole-3-acetic Acid A metabolite of rizatriptan
  45. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride) A minor active metabolite of venlafaxine
  46. GC49870 Desmethyl Sibutramine (hydrochloride) An active metabolite of sibutramine
  47. GC49869 3-Methoxytyrosine An active metabolite of L-DOPA
  48. GC49866 Desmethyl Carvedilol An active metabolite of carvedilol
  49. GC49863 Cytarabine 5′-monophosphate An active metabolite of cytarabine
  50. GC49858 Desipramine-d4 (hydrochloride) An internal standard for the quantification of desipramine
  51. GC49855 Harmalol (hydrochloride hydrate) A β-carboline alkaloid and an active metabolite of harmaline

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