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Serine Protease(丝氨酸蛋白酶)

Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.

  1. Cat.No. 产品名称 Information
  2. GC49221 QLT0267 An ILK inhibitor
  3. GC15682 Chymostatin Chymostatin 是一种有效的组织蛋白酶 G 抑制剂。
  4. GC13967 Tosyllysine Chloromethyl Ketone (hydrochloride) N-α-甲苯磺酰-L-赖氨酸氯甲基酮 (TLCK) 是一种胰蛋白酶样蛋白酶抑制剂,可使 HeLa 细胞对 Fas 介导的细胞死亡敏感。
  5. GC13421 UCF 101 UCF 101 是促凋亡蛋白酶 Omi/HtrA2 的选择性和竞争性抑制剂,对 His-Omi 的 IC50 为 9.5 μM。
  6. GC17711 PPACKII (trifluoroacetate salt) glandular and plasma kallikreins inhibitor
  7. GC10477 PMSF PMSF 是一种不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂,常用于制备细胞裂解物。
  8. GC10613 Nafamostat Mesylate(FUT-175) Nafamostat Mesylate(FUT-175) 是一种合成丝氨酸蛋白酶抑制剂,是一种抗凝剂。
  9. GC12900 Aprotinin Aprotinin 是一种牛胰蛋白酶抑制剂 (BPTI) 抑制剂,可抑制胰蛋白酶和糜蛋白酶,Kis 分别为 0.06 pM 和 9 nM。
  10. GC14502 AEBSF.HCl AEBSF.HCl 是丝氨酸蛋白酶的不可逆抑制剂,例如糜蛋白酶、激肽释放酶、纤溶酶、凝血酶和胰蛋白酶。
  11. GC10027 Leupeptin, Microbial Leupeptin, Microbial 是一种可渗透膜的硫醇蛋白酶抑制剂,可抑制组织蛋白酶 B、组织蛋白酶 H 和组织蛋白酶 L,同时也会损害两性体-溶酶体融合。

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