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AZ1495 目录号 GC33054

规格 价格 库存 购买数量
10mM*1mLinDMSO
¥5,399.00
现货
5mg
¥4,909.00
现货
10mg
¥7,586.00
现货
25mg
¥15,619.00
现货
50mg
¥24,544.00
现货
100mg
¥35,254.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 2196204-23-4 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES C1(C(C2CCOCC2)=CN3)=C3N=CN=C1N[C@@H]4CC[C@@H](N5CCOCC5)CC4
分子式 C21H31N5O2 分子量 385.5
溶解度 DMSO : 10 mg/mL (25.94 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].

[1]. Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.