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ALK (anaplastic lymphoma kinase) is a member of insulin receptor protein-tyrosine superfamily, functioning in embryonic development and involved in cell survival and cell fate.

  1. Cat.No. 产品名称 Information
  2. GC65380 Envonalkib
  3. GC65243 MS4077
  4. GC64966 MS4078 MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1?cells with IC50 of 33 nM.
  5. GC64013 ZX-29 ZX-29 is a potent and selective ALK inhibitor with an IC50s of 2.1, 1.3 and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively.
  6. GC63387 ALK kinase inhibitor-1
  7. GC62516 UNC5293
  8. GC62260 TPX-0131
  9. GC62146 XST-14
  10. GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7
  11. GC50563 TL 13-22 TL 13-22 是 TL13-12 的阴性对照,是一种有效的 ALK 抑制剂,IC50 为 0.54 nM。 TL 13-22 不会降解细胞中的 ALK。
  12. GC50562 TL 13-110 TL 13-110 是 TL13-112 的阴性对照,是一种有效的 ALK 抑制剂,IC50 为 0.34 nM。 TL 13-110 不会降解细胞中的 ALK。
  13. GC50327 LDN 193189 dihydrochloride An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
  14. GC45789 Ceritinib-d7 An internal standard for the quantification of ceritinib
  15. GC36222 HG-14-10-04 An ALK inhibitor
  16. GC36021 F-1
  17. GC35652 CEP-28122 mesylate salt An orally active ALK inhibitor
  18. GC35290 ALK-IN-6
  19. GC35289 ALK-IN-5
  20. GC35287 ALK inhibitor 1 ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
  21. GC35280 Alectinib Hydrochloride Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
  22. GC44903 SMAD3 Inhibitor, SIS3 An inhibitor of TGF-β signaling
  23. GC33319 2-Keto Crizotinib (PF-06260182)
  24. GC33190 Ensartinib (X-396) An ALK inhibitor
  25. GC33062 JH-VIII-157-02
  26. GC32864 Ensartinib hydrochloride (X-396 hydrochloride) An ALK inhibitor
  27. GC19362 Repotrectinib A multi-kinase inhibitor
  28. GC19140 X-376 An ALK inhibitor
  29. GC19084 Brigatinib An orally bioavailable ALK inhibitor
  30. GC19063 Belizatinib An ALK inhibitor
  31. GC15145 CEP-28122 An orally active ALK inhibitor
  32. GC14476 Entrectinib A pan-Trk, ROS1, and ALK inhibitor
  33. GC13225 LDN-214117 A selective ALK1 and ALK2 inhibitor
  34. GC14794 PF-06463922 An orally available inhibitor of ALK and ROS1
  35. GC13902 KRCA 0008 KRCA 0008 是一种选择性 ALK/Ack1 抑制剂,对 ALK 和 Ack1 的 IC50 分别为 12 和 4 nM。 KRCA 0008 可用于癌症研究。
  36. GC17582 ML347 A selective ALK1 and ALK2 inhibitor
  37. GC17035 LDN-212854 An ALK2 inhibitor
  38. GC14298 DMH-1 A potent ALK2 inhibitor
  39. GC12616 Crizotinib hydrochloride Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂,IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化,IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。
  40. GC15273 CEP-37440 A dual inhibitor of FAK1 and ALK
  41. GC13136 (S)-Crizotinib An MTH1 inhibitor
  42. GC14189 AZD-3463 An ALK and IGF-1R inhibitor
  43. GC16025 CH5424802 An orally available inhibitor of ALK
  44. GC12273 GSK1838705A An IGF-1R and IR inhibitor
  45. GC14552 LDK378 An ALK inhibitor
  46. GC16580 LDN-193189 An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
  47. GC17283 AP26113 A potent ALK inhibitor
  48. GC14349 SB525334 A potent inhibitor of TGF-β R1/ALK5 kinase
  49. GC16694 TAE684 (NVP-TAE684) A selective ALK inhibitor
  50. GC14931 LDN193189 Hydrochloride An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
  51. GC17452 LDK378 dihydrochloride LDK378 dihydrochloride (LDK378 dihydrochloride) 是一种选择性、口服生物利用度和 ATP 竞争性的 ALK 酪氨酸激酶抑制剂,IC50 为 200 pM。

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