ALK - Tyrosine Kinase - Signaling Pathways

Cat.No. 产品名称 Information

GC65380 Envonalkib

GC65243 MS4077

GC64966 MS4078 MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1?cells with IC50 of 33 nM.

GC64013 ZX-29 ZX-29 is a potent and selective ALK inhibitor with an IC50s of 2.1, 1.3 and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively.

GC63387 ALK kinase inhibitor-1

GC62516 UNC5293

GC62260 TPX-0131

GC62146 XST-14

GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7

GC50563 TL 13-22 TL 13-22 是 TL13-12 的阴性对照，是一种有效的 ALK 抑制剂，IC50 为 0.54 nM。 TL 13-22 不会降解细胞中的 ALK。

GC50562 TL 13-110 TL 13-110 是 TL13-112 的阴性对照，是一种有效的 ALK 抑制剂，IC50 为 0.34 nM。 TL 13-110 不会降解细胞中的 ALK。

GC50327 LDN 193189 dihydrochloride An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6

GC45789 Ceritinib-d7 An internal standard for the quantification of ceritinib

GC36222 HG-14-10-04 An ALK inhibitor

GC36021 F-1

GC35652 CEP-28122 mesylate salt An orally active ALK inhibitor

GC35290 ALK-IN-6

GC35289 ALK-IN-5

GC35287 ALK inhibitor 1 ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).

GC35280 Alectinib Hydrochloride Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.

GC44903 SMAD3 Inhibitor, SIS3 An inhibitor of TGF-β signaling

GC33319 2-Keto Crizotinib (PF-06260182)

GC33190 Ensartinib (X-396) An ALK inhibitor

GC33062 JH-VIII-157-02

GC32864 Ensartinib hydrochloride (X-396 hydrochloride) An ALK inhibitor

GC19362 Repotrectinib A multi-kinase inhibitor

GC19140 X-376 An ALK inhibitor

GC19084 Brigatinib An orally bioavailable ALK inhibitor

GC19063 Belizatinib An ALK inhibitor

GC15145 CEP-28122 An orally active ALK inhibitor

GC14476 Entrectinib A pan-Trk, ROS1, and ALK inhibitor

GC13225 LDN-214117 A selective ALK1 and ALK2 inhibitor

GC14794 PF-06463922 An orally available inhibitor of ALK and ROS1

GC13902 KRCA 0008 KRCA 0008 是一种选择性 ALK/Ack1 抑制剂，对 ALK 和 Ack1 的 IC50 分别为 12 和 4 nM。 KRCA 0008 可用于癌症研究。

GC17582 ML347 A selective ALK1 and ALK2 inhibitor

GC17035 LDN-212854 An ALK2 inhibitor

GC14298 DMH-1 A potent ALK2 inhibitor

GC12616 Crizotinib hydrochloride Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂，IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。