ALK
ALK (anaplastic lymphoma kinase) is a member of insulin receptor protein-tyrosine superfamily, functioning in embryonic development and involved in cell survival and cell fate.
- Cat.No. 产品名称 Information
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GC65380
Envonalkib
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GC65243
MS4077
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GC64966
MS4078
MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1?cells with IC50 of 33 nM.
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GC64013
ZX-29
ZX-29 is a potent and selective ALK inhibitor with an IC50s of 2.1, 1.3 and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively.
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GC63387
ALK kinase inhibitor-1
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GC62516
UNC5293
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GC62260
TPX-0131
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GC62146
XST-14
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GC48070
SB-431542 (hydrate)
Inhibitor of receptors ALK4, ALK5, and ALK7
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GC50563
TL 13-22
TL 13-22 是 TL13-12 的阴性对照,是一种有效的 ALK 抑制剂,IC50 为 0.54 nM。 TL 13-22 不会降解细胞中的 ALK。
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GC50562
TL 13-110
TL 13-110 是 TL13-112 的阴性对照,是一种有效的 ALK 抑制剂,IC50 为 0.34 nM。 TL 13-110 不会降解细胞中的 ALK。
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GC50327
LDN 193189 dihydrochloride
An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
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GC45789
Ceritinib-d7
An internal standard for the quantification of ceritinib
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GC36222
HG-14-10-04
An ALK inhibitor
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GC36021
F-1
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GC35652
CEP-28122 mesylate salt
An orally active ALK inhibitor
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GC35290
ALK-IN-6
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GC35289
ALK-IN-5
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GC35287
ALK inhibitor 1
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
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GC35280
Alectinib Hydrochloride
Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
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GC44903
SMAD3 Inhibitor, SIS3
An inhibitor of TGF-β signaling
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GC33319
2-Keto Crizotinib (PF-06260182)
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GC33190
Ensartinib (X-396)
An ALK inhibitor
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GC33062
JH-VIII-157-02
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GC32864
Ensartinib hydrochloride (X-396 hydrochloride)
An ALK inhibitor
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GC19362
Repotrectinib
A multi-kinase inhibitor
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GC19140
X-376
An ALK inhibitor
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GC19084
Brigatinib
An orally bioavailable ALK inhibitor
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GC19063
Belizatinib
An ALK inhibitor
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GC15145
CEP-28122
An orally active ALK inhibitor
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GC14476
Entrectinib
A pan-Trk, ROS1, and ALK inhibitor
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GC13225
LDN-214117
A selective ALK1 and ALK2 inhibitor
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GC14794
PF-06463922
An orally available inhibitor of ALK and ROS1
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GC13902
KRCA 0008
KRCA 0008 是一种选择性 ALK/Ack1 抑制剂,对 ALK 和 Ack1 的 IC50 分别为 12 和 4 nM。 KRCA 0008 可用于癌症研究。
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GC17582
ML347
A selective ALK1 and ALK2 inhibitor
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GC17035
LDN-212854
An ALK2 inhibitor
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GC14298
DMH-1
A potent ALK2 inhibitor
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GC12616
Crizotinib hydrochloride
Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂,IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化,IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。
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GC15273
CEP-37440
A dual inhibitor of FAK1 and ALK
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GC13136
(S)-Crizotinib
An MTH1 inhibitor
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GC14189
AZD-3463
An ALK and IGF-1R inhibitor
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GC16025
CH5424802
An orally available inhibitor of ALK
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GC12273
GSK1838705A
An IGF-1R and IR inhibitor
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GC14552
LDK378
An ALK inhibitor
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GC16580
LDN-193189
An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
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GC17283
AP26113
A potent ALK inhibitor
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GC14349
SB525334
A potent inhibitor of TGF-β R1/ALK5 kinase
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GC16694
TAE684 (NVP-TAE684)
A selective ALK inhibitor
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GC14931
LDN193189 Hydrochloride
An inhibitor of BMP receptors ALK1, ALK2, ALK3, and ALK6
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GC17452
LDK378 dihydrochloride
LDK378 dihydrochloride (LDK378 dihydrochloride) 是一种选择性、口服生物利用度和 ATP 竞争性的 ALK 酪氨酸激酶抑制剂,IC50 为 200 pM。