c-Kit(肥大/干细胞生长因子受体)

Cat.No. 产品名称 Information

GC25313 CS-2660 (JNJ-38158471) CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.

GC65948 c-Kit-IN-5-1 AMG-25 is a novel potent and selective c-Kit inhibitor.

GC64810 Bezuclastinib

GC62314 M4205

GC62145 Chiauranib Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.

GC60930 Imatinib D4

GC39612 Imatinib D8

GC38853 Tandutinib hydrochloride An antagonist of PDGFRβ, FLT3, and c-Kit

GC38757 c-Kit-IN-3 hydrochloride

GC38756 c-Kit-IN-3 D-tartrate

GC38595 c-Kit-IN-3

GC37808 Toceranib phosphate A multi-targeted receptor tyrosine kinase inhibitor

GC37538 Ripretinib A KIT and PDGFRα inhibitor

GC36546 Masitinib mesylate An inhibitor of c-Kit

GC36438 Lenvatinib mesylate An inhibitor of VEGFR2 and VEGFR3

GC35705 c-Kit-IN-2

GC35685 CHMFL-KIT-033

GC35682 CHMFL-ABL/KIT-155

GC34708 Pexidartinib hydrochloride A multi-targeted receptor tyrosine kinase inhibitor

GC33362 Amuvatinib hydrochloride (MP470 hydrochloride) A multi-targeted RTK inhibitor

GC33246 AZD3229 Tosylate An inhibitor of c-Kit-driven cell proliferation

GC33027 AZD3229 An inhibitor of c-Kit-driven cell proliferation

GC32867 Flumatinib (HHGV678) A Bcr-Abl inhibitor

GC19332 Sitravatinib A multi-kinase inhibitor

GC19074 Avapritinib A dual inhibitor of KIT and PDGFRα mutant kinases

GC18167 AC710 A PDGFR family kinase inhibitor

GC13961 ISCK03 An inhibitor of SCF/c-kit signaling

GC12222 Pexidartinib (PLX3397) A multi-targeted receptor tyrosine kinase inhibitor

GC17959 AZD2932 A multi-kinase inhibitor

GC15075 PLX647 A dual inhibitor of FMS and KIT

GC10314 Imatinib (STI571) 伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。

GC14292 Apatinib Mesylate

A selective VEGFR2 inhibitor

GC15254 Tandutinib (MLN518) An antagonist of PDGFRβ, FLT3, and c-Kit

GC13914 Flumatinib mesylate A Bcr-Abl inhibitor

GC11763 Telatinib (BAY 57-9352) A multi-kinase inhibitor

GC12730 Pazopanib Hydrochloride A multi-kinase inhibitor

GC11336 Motesanib Diphosphate (AMG-706) A multikinase inhibitor

GC15454 Lenvatinib (E7080)

An inhibitor of VEGFR2 and VEGFR3

GC14957 OSI-930 A dual inhibitor of Kit and VEGFR2

GC15779 Cabozantinib (XL184, BMS-907351) A VEGFR2 inhibitor

GC13547 Dovitinib (TKI-258, CHIR-258) A multi-kinase inhibitor

GC11759 Imatinib Mesylate (STI571) An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit

GC17958 Linifanib (ABT-869) A dual VEGFR and PDGFR family kinase inhibitor

GC13410 Masitinib (AB1010) An inhibitor of c-Kit

GC10719 Toceranib A multi-targeted receptor tyrosine kinase inhibitor

GC14315 SU14813 maleate A dual VEGFR and PDGFR family kinase inhibitor

GC14733 SU14813 A dual VEGFR and PDGFR family kinase inhibitor

GC13012 Motesanib Motesanib (AMG 706) 是一种有效的 ATP 竞争性 VEGFR1/2/3 抑制剂，IC50 分别为 2 nM/3 nM/6 nM，对 Kit 具有相似的活性，对 VEGFR 的选择性比对 VEGFR 的选择性高约 10 倍PDGFR 和 Ret。

GC13264 Ki20227 A c-Fms kinase inhibitor

GC11171 DCC-2618 A dual inhibitor of c-Kit and c-MET