c-Kit(肥大/干细胞生长因子受体)
C-kit is a type of receptor tyrosine kinase and a type of tumor marker, also called CD117 and stem cell factor receptor.
- Cat.No. 产品名称 Information
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GC25313
CS-2660 (JNJ-38158471)
CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM,while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
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GC65948
c-Kit-IN-5-1
AMG-25 is a novel potent and selective c-Kit inhibitor.
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GC64810
Bezuclastinib
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GC62314
M4205
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GC62145
Chiauranib
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
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GC60930
Imatinib D4
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GC39612
Imatinib D8
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GC38853
Tandutinib hydrochloride
An antagonist of PDGFRβ, FLT3, and c-
Kit -
GC38757
c-Kit-IN-3 hydrochloride
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GC38756
c-Kit-IN-3 D-tartrate
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GC38595
c-Kit-IN-3
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GC37808
Toceranib phosphate
A multi-targeted receptor tyrosine kinase inhibitor
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GC37538
Ripretinib
A KIT and PDGFRα inhibitor
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GC36546
Masitinib mesylate
An inhibitor of c-Kit
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GC36438
Lenvatinib mesylate
An inhibitor of VEGFR2 and VEGFR3
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GC35705
c-Kit-IN-2
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GC35685
CHMFL-KIT-033
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GC35682
CHMFL-ABL/KIT-155
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GC34708
Pexidartinib hydrochloride
A multi-targeted receptor tyrosine kinase inhibitor
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GC33362
Amuvatinib hydrochloride (MP470 hydrochloride)
A multi-targeted RTK inhibitor
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GC33246
AZD3229 Tosylate
An inhibitor of c-Kit-driven cell proliferation
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GC33027
AZD3229
An inhibitor of c-Kit-driven cell proliferation
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GC32867
Flumatinib (HHGV678)
A Bcr-Abl inhibitor
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GC19332
Sitravatinib
A multi-kinase inhibitor
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GC19074
Avapritinib
A dual inhibitor of KIT and PDGFRα mutant kinases
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GC18167
AC710
A PDGFR family kinase inhibitor
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GC13961
ISCK03
An inhibitor of SCF/c-kit signaling
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GC12222
Pexidartinib (PLX3397)
A multi-targeted receptor tyrosine kinase inhibitor
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GC17959
AZD2932
A multi-kinase inhibitor
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GC15075
PLX647
A dual inhibitor of FMS and KIT
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GC10314
Imatinib (STI571)
伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂,可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用,将其锁定在封闭或自我抑制的构象中,从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
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GC14292
Apatinib Mesylate
A selective VEGFR2 inhibitor
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GC15254
Tandutinib (MLN518)
An antagonist of PDGFRβ, FLT3, and c-Kit
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GC13914
Flumatinib mesylate
A Bcr-Abl inhibitor
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GC11763
Telatinib (BAY 57-9352)
A multi-kinase inhibitor
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GC12730
Pazopanib Hydrochloride
A multi-kinase inhibitor
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GC11336
Motesanib Diphosphate (AMG-706)
A multikinase inhibitor
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GC15454
Lenvatinib (E7080)
An inhibitor of VEGFR2 and VEGFR3
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GC14957
OSI-930
A dual inhibitor of Kit and VEGFR2
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GC15779
Cabozantinib (XL184, BMS-907351)
A VEGFR2 inhibitor
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GC13547
Dovitinib (TKI-258, CHIR-258)
A multi-kinase inhibitor
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GC11759
Imatinib Mesylate (STI571)
An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
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GC17958
Linifanib (ABT-869)
A dual VEGFR and PDGFR family kinase inhibitor
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GC13410
Masitinib (AB1010)
An inhibitor of c-Kit
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GC10719
Toceranib
A multi-targeted receptor tyrosine kinase inhibitor
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GC14315
SU14813 maleate
A dual VEGFR and PDGFR family kinase inhibitor
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GC14733
SU14813
A dual VEGFR and PDGFR family kinase inhibitor
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GC13012
Motesanib
Motesanib (AMG 706) 是一种有效的 ATP 竞争性 VEGFR1/2/3 抑制剂,IC50 分别为 2 nM/3 nM/6 nM,对 Kit 具有相似的活性,对 VEGFR 的选择性比对 VEGFR 的选择性高约 10 倍PDGFR 和 Ret。
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GC13264
Ki20227
A c-Fms kinase inhibitor
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GC11171
DCC-2618
A dual inhibitor of c-Kit and c-MET