c-MET(间质表皮转化因子)
c-MET, also called MET, is a membrane receptor that is essential for embryonic development and wound healing.
- Cat.No. 产品名称 Information
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GC68018
MET kinase-IN-2
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GC65966
BPI-9016M
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GC65894
ABN401
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GC65478
Gemnelatinib
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GC64961
CSF1R-IN-2
An inhibitor of Src, MET, and FMS kinases
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GC64947
Glumetinib
A potent c-Met inhibitor
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GC64708
Fosgonimeton
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GC63215
Terevalefim
Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation.
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GC62597
DS-1205b free base
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GC62268
SYN1143
AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.
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GC62266
XL092
XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.
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GC50152
Norleual
Norleual 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子 (HGF)/c-Met 抑制剂,IC50 为 3 pM。
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GC38894
Bozitinib
Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.
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GC37849
Tyrosine kinase inhibitor
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GC36744
Ningetinib Tosylate
A multi-kinase inhibitor
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GC36625
MK-8033 hydrochloride
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GC36585
Merestinib dihydrochloride
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GC35717
c-met-IN-1
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GC35716
c-Met inhibitor 1
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GC35095
2-Phospho-L-ascorbic acid trisodium salt
Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
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GC34811
SRI 31215 TFA
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GC33362
Amuvatinib hydrochloride (MP470 hydrochloride)
A multi-targeted RTK inhibitor
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GC33273
TAS-115 mesylate (TAS-115 methanesulfonate)
A multi-kinase inhibitor
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GC33266
JNJ-38877618
JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).
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GC33203
c-Met-IN-2
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GC33190
Ensartinib (X-396)
An ALK inhibitor
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GC33189
SAR125844
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
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GC33173
TAS-115
A multi-kinase inhibitor
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GC32864
Ensartinib hydrochloride (X-396 hydrochloride)
An ALK inhibitor
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GC30768
Dihexa (PNB-0408)
Dihexa (PNB-0408) (N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide) is an oral active, blood-brain barrier-permeable angiotensin IV analogue.
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GC19321
Savolitinib
An inhibitor of c-Met
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GC19317
S49076
S49076 是一种新型、有效的 MET、AXL/MER 和 FGFR1/2/3 抑制剂,IC50 值低于 20 nM。
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GC19166
Glesatinib hydrochloride
Glesatinib hydrochloride (MGCD265 hydrochloride) 是一种具有口服活性的强效 MET/SMO 双重抑制剂。 Glesatinib hydrochloride 是一种酪氨酸激酶抑制剂,可拮抗 P-糖蛋白 (P-gp) 介导的非小细胞肺癌 (NSCLC) 中的多药耐药 (MDR)。
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GC19140
X-376
An ALK inhibitor
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GC19108
SCR-1481B1
A pyridone
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GC19102
CEP-40783
A multi-kinase inhibitor
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GC18211
Ningetinib
A multi-kinase inhibitor
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GC14951
Meleagrin
A Fabl inhibitor
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GC15655
AMG 337
A selective c-Met inhibitor
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GC14488
NPS-1034
A dual MET/AXL inhibitor
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GC17772
BMS-817378
Potent ATP competitive inhibitor of Met/VEGFR2
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GC16604
Altiratinib
A multiple kinase inhibitor
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GC12616
Crizotinib hydrochloride
Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂,IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化,IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。
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GC13833
BMS-794833
An inhibitor of c-Met and VEGFR2
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GC11555
ZM 323881 HCl
A potent and selective VEGFR2 inhibitor
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GC17715
Golvatinib (E7050)
A dual inhibitor of c-Met and VEGFR2
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GC12531
Cabozantinib malate (XL184)
A VEGFR2 inhibitor
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GC13136
(S)-Crizotinib
An MTH1 inhibitor
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GC16972
NVP-BVU972
A Met kinase inhibitor
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GC16337
MK-2461
A c-MET inhibitor