c-MET(间质表皮转化因子)
c-MET, also called MET, is a membrane receptor that is essential for embryonic development and wound healing.
- Cat.No. 产品名称 Information
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GC70077
Tunlametinib
Tunlametinib 是一种抗肿瘤化合物,是一种酪氨酸激酶 (tyrosine kinase) 抑制剂。
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GC69817
Rilotumumab
Rilotumumab (AMG 102) 是一种 anti-HGF (抗肝细胞生长因子) 的单克隆抗体,抑制 HGF/MET 驱动的信号传导。Rilotumumab 具有抗肿瘤活性,可用于去势抵抗性前列腺癌 (CRPC) 和实体瘤的研究。
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GC69623
Onartuzumab
Onartuzumab (MetMAb) 是一种人源化亲和成熟的单价单克隆抗体,抑制受体酪氨酸激酶 MET。Onartuzumab 可有效抑制 HGF 结合、受体磷酸化和信号转导。Onartuzumab 具有抗体样药代动力学和抗肿瘤活性。
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GC69584
Norleual TFA
Norleual TFA 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子 (HGF)/c-Met 抑制剂,IC50 为 3 pM。Norleual TFA 还是一种 AT4 拮抗剂,具有强大的抗血管生成活性。
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GC69460
Mefatinib
Mefatinib 是一种有效的酪氨酸激酶抑制剂,具有抗肿瘤活性。
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GC69459
Mefatinib free base
Mefatinib free base 是一种有效的酪氨酸激酶抑制剂,具有抗肿瘤活性。
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GC69110
Ficlatuzumab
Ficlatuzumab 是一种靶向人肝细胞生长因子 (HGF) 的单克隆抗体 (McAb)。Ficlatuzumab 能够阻断 HGF/c-Met 信号通路的激活,抑制 c-Met 受体介导的癌细胞增殖、迁移和侵袭。
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GC69058
Emibetuzumab
Emibetuzumab (LY2875358) 是一种人源化二价 MET 抗体 (IgG4 型)。Emibetuzumab 具有较高的中和与内化活性,能有效抑制 HGF 依赖性和非依赖性 MET 通路的激活和肿瘤生长。Emibetuzumab 可用于癌症的研究。
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GC68828
Capmatinib dihydrochloride hydrate
Capmatinib (INC280; INCB28060) dihydrochloride hydrate 是一种有效的、口服活性的、选择性的、ATP 竞争性的 c-Met 激酶抑制剂 (IC50=0.13 nM)。Capmatinib dihydrochloride hydrate 可抑制 c-MET 的磷酸化,以及 c-MET 通路下游效应蛋白如 ERK1/2、AKT、FAK、GAB1 和 STAT3/5。Capmatinib dihydrochloride hydrate 有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移,并有效诱导细胞凋亡。在肿瘤小鼠模型中表现出抗肿瘤活性。Capmatinib dihydrochloride hydrate 主要由 CYP3A4 和醛氧化酶代谢。
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GC68018
MET kinase-IN-2
MET kinase-IN-2 是一种有效的选择性的,具有口服活性的 MET 激酶抑制剂,IC50 值为 7.4 nM。MET kinase-IN-2 具有抗肿瘤活性。
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GC65966
BPI-9016M
BPI-9016M是一种有效的,口服活性的,选择性的双重 c-Met 和 AXL 酪氨酸激酶抑制剂。BPI-9016M抑制肺腺癌的肿瘤细胞生长,迁移和侵袭。
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GC65894
ABN401
ABN401 是一种高效且具有选择性的 ATP 竞争性 c-MET 抑制剂,IC50 为 10 nM。ABN401 对嗜 MET 的癌细胞具有细胞毒性。ABN401 可以抑制肿瘤组织中 c-MET 的磷酸化。ABN401 可用于抗癌研究。
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GC65478
Gemnelatinib
Gemnelatinib 是一种酪氨酸激酶抑制剂 (WO2018077227,实施例1)。Gemnelatinib 可用于癌症的研究。
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GC64961
CSF1R-IN-2
An inhibitor of Src, MET, and FMS kinases
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GC64947
Glumetinib
A potent c-Met inhibitor
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GC64708
Fosgonimeton
Fosgonimeton (ATH-1017) 是一种肝细胞生长因子受体激动剂 (WO2017210489)。
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GC63215
Terevalefim
Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation.
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GC62597
DS-1205b free base
DS-1205b free base 是一种有效和选择性的 AXL 激酶抑制剂,IC50 值为 1.3 nM。DS-1205b free base 还可以抑制 MER,MET 和 TRKA,IC50 值分别为 63、104 和 407 nM。 DS-1205b free base 可以抑制细胞迁移和肿瘤生长。
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GC62268
SYN1143
AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.
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GC62266
XL092
XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.
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GC50152
Norleual
Norleual 是一种血管紧张素 (Ang) IV 类似物,是一种肝细胞生长因子 (HGF)/c-Met 抑制剂,IC50 为 3 pM。
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GC38894
Bozitinib
Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.
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GC37849
Tyrosine kinase inhibitor
本产品为酪氨酸激酶抑制剂。
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GC36744
Ningetinib Tosylate
A multi-kinase inhibitor
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GC36625
MK-8033 hydrochloride
MK8033盐酸盐是ATP竞争性c-Met/Ron双重抑制剂,对野生型c-Met的IC50为1 nM,对c-Met N1100Y的IC50为2.0 nM。
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GC36585
Merestinib dihydrochloride
Merestinib dihydrochloride (LY2801653 dihydrochloride) 是一种II型ATP竞争性的 MET 抑制剂,Ki 值为 2 nM。
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GC35717
c-met-IN-1
c-met-IN-1 (compound 16) 是一种高效选择性的 c-Met 抑制剂,IC50 值为 1.1 nM,具有抗肿瘤活性。
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GC35716
c-Met inhibitor 1
c-Met inhibitor 1是c-Met信号通路抑制剂,可作用于胃癌,胰腺癌和恶性胶质瘤。
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GC35095
2-Phospho-L-ascorbic acid trisodium salt
Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
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GC34811
SRI 31215 TFA
SRI31215(TFA)是一种matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂,IC50值分别为0.69μM、0.65μM、0.3μM,SRI31215通过阻断pro-HGF的活化,从而模拟了HAI-1/2的活性。
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GC33362
Amuvatinib hydrochloride (MP470 hydrochloride)
A multi-targeted RTK inhibitor
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GC33273
TAS-115 mesylate (TAS-115 methanesulfonate)
A multi-kinase inhibitor
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GC33266
JNJ-38877618
JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).
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GC33203
c-Met-IN-2
c-Met-IN-2是一种有效的,选择性的,可口服的c-Met抑制剂,IC50值为0.6nM,具有抗肿瘤活性。
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GC33190
Ensartinib (X-396)
An ALK inhibitor
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GC33189
SAR125844
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
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GC33173
TAS-115
A multi-kinase inhibitor
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GC32864
Ensartinib hydrochloride (X-396 hydrochloride)
An ALK inhibitor
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GC30768
Dihexa (PNB-0408)
Dihexa (PNB-0408) (N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide) is an oral active, blood-brain barrier-permeable angiotensin IV analogue.
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GC19321
Savolitinib
An inhibitor of c-Met
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GC19317
S49076
S49076 是一种新型、有效的 MET、AXL/MER 和 FGFR1/2/3 抑制剂,IC50 值低于 20 nM。
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GC19166
Glesatinib hydrochloride
Glesatinib hydrochloride (MGCD265 hydrochloride) 是一种具有口服活性的强效 MET/SMO 双重抑制剂。 Glesatinib hydrochloride 是一种酪氨酸激酶抑制剂,可拮抗 P-糖蛋白 (P-gp) 介导的非小细胞肺癌 (NSCLC) 中的多药耐药 (MDR)。
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GC19140
X-376
An ALK inhibitor
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GC19108
SCR-1481B1
A pyridone
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GC19102
CEP-40783
A multi-kinase inhibitor
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GC18211
Ningetinib
A multi-kinase inhibitor
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GC14951
Meleagrin
A Fabl inhibitor
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GC15655
AMG 337
A selective c-Met inhibitor
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GC14488
NPS-1034
A dual MET/AXL inhibitor
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GC17772
BMS-817378
Potent ATP competitive inhibitor of Met/VEGFR2