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Home >> Signaling Pathways >> Tyrosine Kinase >> c-MET

c-MET(间质表皮转化因子)

c-MET, also called MET, is a membrane receptor that is essential for embryonic development and wound healing.

  1. Cat.No. 产品名称 Information
  2. GC68018 MET kinase-IN-2
  3. GC65966 BPI-9016M
  4. GC65894 ABN401
  5. GC65478 Gemnelatinib
  6. GC64961 CSF1R-IN-2 An inhibitor of Src, MET, and FMS kinases
  7. GC64947 Glumetinib A potent c-Met inhibitor
  8. GC64708 Fosgonimeton
  9. GC63215 Terevalefim Terevalefim (ANG-3777), a small molecule hepatocyte growth factor (HGF) mimetic, induces c-MET dimerization and phosphorylation, reducing apoptosis and increasing cellular proliferation.
  10. GC62597 DS-1205b free base
  11. GC62268 SYN1143 AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.
  12. GC62266 XL092 XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.
  13. GC50152 Norleual

    Norleual 是一种血管紧张素 (Ang) IV 类似物，是一种肝细胞生长因子 (HGF)/c-Met 抑制剂，IC50 为 3 pM。
  14. GC38894 Bozitinib Bozitinib (PLB-1001, CBT-101, APL-101, CBI-3103) is a highly selective ATP-competitive c-Met inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) selectively inhibits MET-altered tumor cells in preclinical models.
  15. GC37849 Tyrosine kinase inhibitor
  16. GC36744 Ningetinib Tosylate A multi-kinase inhibitor
  17. GC36625 MK-8033 hydrochloride
  18. GC36585 Merestinib dihydrochloride
  19. GC35717 c-met-IN-1
  20. GC35716 c-Met inhibitor 1
  21. GC35095 2-Phospho-L-ascorbic acid trisodium salt Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
  22. GC34811 SRI 31215 TFA
  23. GC33362 Amuvatinib hydrochloride (MP470 hydrochloride) A multi-targeted RTK inhibitor
  24. GC33273 TAS-115 mesylate (TAS-115 methanesulfonate) A multi-kinase inhibitor
  25. GC33266 JNJ-38877618 JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable Met (c-Met) kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant Met (c-Met) (2 and 3 nM IC50).
  26. GC33203 c-Met-IN-2
  27. GC33190 Ensartinib (X-396) An ALK inhibitor
  28. GC33189 SAR125844 SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
  29. GC33173 TAS-115 A multi-kinase inhibitor
  30. GC32864 Ensartinib hydrochloride (X-396 hydrochloride) An ALK inhibitor
  31. GC30768 Dihexa (PNB-0408)

    Dihexa (PNB-0408) (N-hexanoic-Tyr-Ile-(6)-amino hexanoic amide) is an oral active, blood-brain barrier-permeable angiotensin IV analogue.
  32. GC19321 Savolitinib An inhibitor of c-Met
  33. GC19317 S49076 S49076 是一种新型、有效的 MET、AXL/MER 和 FGFR1/2/3 抑制剂，IC50 值低于 20 nM。
  34. GC19166 Glesatinib hydrochloride Glesatinib hydrochloride (MGCD265 hydrochloride) 是一种具有口服活性的强效 MET/SMO 双重抑制剂。 Glesatinib hydrochloride 是一种酪氨酸激酶抑制剂，可拮抗 P-糖蛋白 (P-gp) 介导的非小细胞肺癌 (NSCLC) 中的多药耐药 (MDR)。
  35. GC19140 X-376 An ALK inhibitor
  36. GC19108 SCR-1481B1 A pyridone
  37. GC19102 CEP-40783 A multi-kinase inhibitor
  38. GC18211 Ningetinib A multi-kinase inhibitor
  39. GC14951 Meleagrin A Fabl inhibitor
  40. GC15655 AMG 337 A selective c-Met inhibitor
  41. GC14488 NPS-1034 A dual MET/AXL inhibitor
  42. GC17772 BMS-817378 Potent ATP competitive inhibitor of Met/VEGFR2
  43. GC16604 Altiratinib A multiple kinase inhibitor
  44. GC12616 Crizotinib hydrochloride Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂，IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。
  45. GC13833 BMS-794833 An inhibitor of c-Met and VEGFR2
  46. GC11555 ZM 323881 HCl A potent and selective VEGFR2 inhibitor
  47. GC17715 Golvatinib (E7050) A dual inhibitor of c-Met and VEGFR2
  48. GC12531 Cabozantinib malate (XL184) A VEGFR2 inhibitor
  49. GC13136 (S)-Crizotinib An MTH1 inhibitor
  50. GC16972 NVP-BVU972 A Met kinase inhibitor
  51. GC16337 MK-2461 A c-MET inhibitor

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