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Home >> Signaling Pathways >> Tyrosine Kinase >> c-MET

c-MET(间质表皮转化因子)

c-MET, also called MET, is a membrane receptor that is essential for embryonic development and wound healing.

Products for  c-MET

  1. Cat.No. 产品名称 Information
  2. GC16604 Altiratinib A multiple kinase inhibitor
  3. GC12616 Crizotinib hydrochloride Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂，IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。
  4. GC13833 BMS-794833 An inhibitor of c-Met and VEGFR2
  5. GC11555 ZM 323881 HCl A potent and selective VEGFR2 inhibitor
  6. GC17715 Golvatinib (E7050) A dual inhibitor of c-Met and VEGFR2
  7. GC12531 Cabozantinib malate (XL184) A VEGFR2 inhibitor
  8. GC13136 (S)-Crizotinib An MTH1 inhibitor
  9. GC16972 NVP-BVU972 A Met kinase inhibitor
  10. GC16337 MK-2461 A c-MET inhibitor
  11. GC17866 INCB28060 An inhibitor of HGFR (c-Met)
  12. GC11481 AMG-458 AMG-458 是一种有效的、选择性的、可口服的 c-Met 抑制剂，对人和小鼠 c-Met 的 Ki 值分别为 1.2 nM 和 2.0 nM。
  13. GC14256 Tivantinib (ARQ 197) An inhibitor of c-Met
  14. GC14214 BMS-777607 A Met kinase family inhibitor
  15. GC15735 Foretinib (GSK1363089) A broad-spectrum tyrosine kinase inhibitor
  16. GC13598 MGCD-265 A c-Met and VEGFR2 inhibitor
  17. GC12600 AMG-208 A potent c-Met inhibitor
  18. GC12585 JNJ-38877605 An inhibitor of Met kinase
  19. GC15779 Cabozantinib (XL184, BMS-907351) A VEGFR2 inhibitor
  20. GC15664 SGX-523 A potent inhibitor of c-Met
  21. GC12729 PF-04217903 A c-Met inhibitor
  22. GC11089 SU11274 A potent, selective inhibitor of c-Met
  23. GC11733 PHA-665752 A selective c-Met inhibitor
  24. GC15307 SU5416

    A tyrosine kinase inhibitor
  25. GC15733 PF-04217903 methanesulfonate A c-Met inhibitor
  26. GC13140 MK-8033 MK-8033 是一种具有口服活性的 ATP 竞争性 c-Met/Ron 双重抑制剂（IC50:1 nM (c-Met),7 nM (Ron)），优先与活化的激酶构象结合。 MK-8033 可用于癌症的研究，例如乳腺癌和膀胱癌、非小细胞肺癌 (NSCLC)。
  27. GC11057 LY2801653 A MET kinase inhibitor
  28. GC10466 EMD-1214063

    EMD-1214063 (Tepotinib, MSC2156119J) is a novel potent and highly selective reversible, ATP-competitive small molecule c-Met inhibitor .
  29. GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor
  30. GC14729 (R)-Crizotinib A c-MET and ALK receptor tyrosine kinase inhibitor

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