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Amuvatinib hydrochloride (MP470 hydrochloride) Sale

(Synonyms: MP470 hydrochloride; HPK 56 hydrochloride) 目录号 : GC33362

A multi-targeted RTK inhibitor

Amuvatinib hydrochloride (MP470 hydrochloride) Chemical Structure

Cas No.:1055986-67-8

规格 价格 库存 购买数量
5mg
¥982.00
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10mg
¥1,607.00
现货
50mg
¥4,820.00
现货
100mg
¥8,479.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Amuvatinib is a multi-targeted inhibitor of receptor tyrosine kinases that inhibits c-Kit, platelet-derived growth factor receptor α (PDGFRα), and c-Met (IC50s = 10, 40, and 81 nM, respectively).1 It inhibits growth and induces apoptosis in prostate cancer cell lines, with additive effects achieved when combined with erlotinib .1 Amuvatinib sensitizes cancer cells to radiation and chemotherapeutic compounds, in part by inhibiting homologous recombination.2,3,4

1.Qi, W., Cooke, L.S., Stejskal, A., et al.MP470, a novel receptor tyrosine kinase inhibitor, in combination with erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancerBMC Cancer9(142)1-12(2009) 2.Padda, S., Neal, J.W., and Wakelee, H.A.MET inhibitors in combination with other therapies in non-small cell lung cancerTransl. Lung Cancer Res.1(4)238-253(2012) 3.Welsh, J.W., Mahadevan, D., Ellsworth, R., et al.The c-Metreceptortyrosine kinaseinhibitor MP470 radiosensitizes glioblastomacellsRadiat. Oncol.4(69)(2009) 4.Zhao, H., Luoto, K.R., Meng, A.X., et al.The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombinationRadiother. Oncol.101(1)59-65(2011)

Chemical Properties

Cas No. 1055986-67-8 SDF
别名 MP470 hydrochloride; HPK 56 hydrochloride
Canonical SMILES S=C(N1CCN(C2=C3OC4=CC=CC=C4C3=NC=N2)CC1)NCC5=CC=C6OCOC6=C5.[x].Cl
分子式 C23H21N5O3S.xHCl 分子量
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。
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