Spleen Tyrosine Kinase (Syk)(脾酪氨酸激酶 (Syk))
Syk is a family of non-receptor cytoplasmic tyrosine kinases that plays a role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.
- Cat.No. 产品名称 Information
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GC25787
PRT-060318 2HCl
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.
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GC64889
GSK2646264
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GC64279
Sovleplenib
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GC63455
Cevidoplenib dimesylate
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GC63429
Cevidoplenib
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GC62592
Syk-IN-4
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GC62456
SRX3207
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
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GC61942
Syk-IN-1
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GC38630
Lanraplenib succinate
A Syk inhibitor
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GC37723
TAK-659
TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
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GC36423
Lanraplenib
A Syk inhibitor
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GC44978
Syk Inhibitor II
A selective blocker of spleen tyrosine kinase activity
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GC33874
R112
A Syk inhibitor
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GC33041
Gusacitinib (ASN-002)
A dual inhibitor of JAKs and Syk family kinases
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GC31819
PRT062607 (P505-15)
A potent, orally bioavailable Syk inhibitor
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GC19344
TAK-659 hydrochloride
TAK-659 hydrochloride 是一种高效、选择性、可逆和口服的脾酪氨酸激酶 (SYK) 和 fms 相关酪氨酸激酶 3 (FLT3) 双重抑制剂,对 SYK 和 FLT3 的 IC50 分别为 3.2 nM 和 4.6 nM。 TAK-659 hydrochloride 在肿瘤细胞中诱导细胞死亡,但在非肿瘤细胞中不诱导细胞死亡,并具有治疗慢性淋巴细胞白血病 (CLL) 的潜力。
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GC11321
PRT-060318
A potent and selective Syk inhibitor
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GC15466
RO9021
RO9021 是一种具有口服生物利用度的新型 ATP 竞争性 SYK 抑制剂,平均 IC50 为 5.6 nM。
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GC11209
Cerdulatinib (PRT062070)
A dual inhibitor of Syk and JAKs
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GC16430
GS-9973
A selective spleen tyrosine kinase inhibitor
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GC11044
Fostamatinib (R788)
Fostamatinib (R788) is the oral prodrug of the active compound R406, a relatively selective small molecule inhibitor of Syk .
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GC15709
R788 disodium hexahydrate
Fostamatinib (R788) 二钠六水合物是活性化合物 R406 的口服前药。
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GC10048
MNS
An inhibitor of Src, Syk, and platelet aggregation
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GC16796
R406
A potent and selective Syk inhibitor
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GC11811
R788 disodium
A prodrug of a Syk inhibitor
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GC15658
R406(free base)
A potent and selective Syk inhibitor
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GC10499
PRT062607 Hydrochloride
PRT062607 Hydrochloride (P505-15 Hydrochloride) 是一种高度特异性和有效的纯化 Syk 抑制剂 (IC50 1-2 nM)。
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GC12136
BAY 61-3606 dihydrochloride
BAY 61-3606 dihydrochloride 是一种可口服的、ATP 竞争性、可逆和高选择性的 Syk 抑制剂,Ki 为 7.5 nM,IC50 为 10 nM。
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GC16389
BAY 61-3606
A Syk inhibitor
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GN10503
Piceatannol
Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol .