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Home >> Signaling Pathways >> Tyrosine Kinase >> Spleen Tyrosine Kinase (Syk)

Spleen Tyrosine Kinase (Syk)(脾酪氨酸激酶 (Syk))

Syk is a family of non-receptor cytoplasmic tyrosine kinases that plays a role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.

  1. Cat.No. 产品名称 Information
  2. GC25787 PRT-060318 2HCl PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.
  3. GC68447 GSK143 dihydrochloride GSK143 dihydrochloride 是一种具有口服活性，高选择性的脾酪氨酸激酶 (Syk) 抑制剂，pIC50 为 7.5。GSK143 dihydrochloride 抑制 Erk 磷酸化 (pErk: pIC50=7.1)。GSK143 dihydrochloride 可以减轻炎症，并防止小鼠肠道肌层中免疫细胞的募集。
  4. GC64889 GSK2646264 GSK2646264 (Compound 44) 是一种有效的、选择性的脾酪氨酸激酶 (SYK) 抑制剂，pIC50 值为7.1。GSK2646264 对其他激酶也有抑制效果，对 LCK、LRRK2、GSK3β、JAK2、VEGFR2、Aurora B 和 Aurora A 的 pIC50 分别为 5.4、5.4、5.3、5、4.5、<4.6 和 <4.3。GSK2646264 可渗透到皮肤的表皮和真皮层。
  5. GC64279 Sovleplenib Sovleplenib (HMPL-523) 是一种高效的、可口服的选择性 SYK 抑制剂，IC50 为 25 nM。具有抗肿瘤活性。Sovleplenib 可用于免疫性血小板减少症（ITP）的研究。
  6. GC63455 Cevidoplenib dimesylate Cevidoplenib 是一种具有口服活性的脾脏酪氨酸激酶 (Syk) 抑制剂，具有潜在的抗炎和免疫调节作用。
  7. GC63429 Cevidoplenib

    Cevidoplenib is an orally active spleen tyrosine kinase (Syk) inhibitor with potential anti-inflammatory and immunomodulatory effects[1].
  8. GC62592 Syk-IN-4 Syk-IN-4 是一种有效的，具有口服活性的选择性 SYK 抑制剂，IC50 为 0.31 nM。SYK 已成为自身免疫和血液肿瘤等多个研究领域的潜在靶标。
  9. GC62456 SRX3207 SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
  10. GC61942 Syk-IN-1 Syk-IN-1 (compound 4) 是一种有效的 Syk 抑制剂，IC50为 35 nM。
  11. GC38630 Lanraplenib succinate A Syk inhibitor
  12. GC37723 TAK-659 TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
  13. GC36423 Lanraplenib A Syk inhibitor
  14. GC44978 Syk Inhibitor II A selective blocker of spleen tyrosine kinase activity
  15. GC33874 R112 A Syk inhibitor
  16. GC33041 Gusacitinib (ASN-002) A dual inhibitor of JAKs and Syk family kinases
  17. GC31819 PRT062607 (P505-15) A potent, orally bioavailable Syk inhibitor
  18. GC19344 TAK-659 hydrochloride TAK-659 hydrochloride 是一种高效、选择性、可逆和口服的脾酪氨酸激酶 (SYK) 和 fms 相关酪氨酸激酶 3 (FLT3) 双重抑制剂，对 SYK 和 FLT3 的 IC50 分别为 3.2 nM 和 4.6 nM。 TAK-659 hydrochloride 在肿瘤细胞中诱导细胞死亡，但在非肿瘤细胞中不诱导细胞死亡，并具有治疗慢性淋巴细胞白血病 (CLL) 的潜力。
  19. GC11321 PRT-060318 A potent and selective Syk inhibitor
  20. GC15466 RO9021 RO9021 是一种具有口服生物利用度的新型 ATP 竞争性 SYK 抑制剂，平均 IC50 为 5.6 nM。
  21. GC11209 Cerdulatinib (PRT062070) A dual inhibitor of Syk and JAKs
  22. GC16430 GS-9973 A selective spleen tyrosine kinase inhibitor
  23. GC11044 Fostamatinib (R788)

    Fostamatinib (R788) is the oral prodrug of the active compound R406, a relatively selective small molecule inhibitor of Syk .
  24. GC15709 R788 disodium hexahydrate Fostamatinib (R788) 二钠六水合物是活性化合物 R406 的口服前药。
  25. GC10048 MNS An inhibitor of Src, Syk, and platelet aggregation
  26. GC16796 R406 A potent and selective Syk inhibitor
  27. GC11811 R788 disodium A prodrug of a Syk inhibitor
  28. GC15658 R406(free base) A potent and selective Syk inhibitor
  29. GC10499 PRT062607 Hydrochloride PRT062607 Hydrochloride (P505-15 Hydrochloride) 是一种高度特异性和有效的纯化 Syk 抑制剂 (IC50 1-2 nM)。
  30. GC12136 BAY 61-3606 dihydrochloride BAY 61-3606 dihydrochloride 是一种可口服的、ATP 竞争性、可逆和高选择性的 Syk 抑制剂，Ki 为 7.5 nM，IC50 为 10 nM。
  31. GC16389 BAY 61-3606 A Syk inhibitor
  32. GN10503 Piceatannol

    Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol .

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