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Home >> Signaling Pathways >> Tyrosine Kinase >> Trk

Trk(酪氨酸激酶)

Trk is a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

  1. Cat.No. 产品名称 Information
  2. GC65009 PF-6683324
  3. GC62597 DS-1205b free base
  4. GC50660 HIOC HIOC 是 TrkB（原肌球蛋白相关激酶 B）受体的有效和选择性激活剂。
  5. GC60372 TrkA-IN-1
  6. GC50346 PF 06273340 PF 06273340 是一种有效的、选择性的、口服生物可利用的和外周受限的 pan Trk 抑制剂。
  7. GC36425 LOXO-101 (Larotrectinib) A pan-Trk inhibitor
  8. GC33112 CH7057288 CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.
  9. GC33090 AZ-23 (AZ23)
  10. GC32808 Selitrectinib (LOXO-195) A Trk kinase inhibitor
  11. GC32623 CE-245677
  12. GC31676 Tavilermide (MIM-D3)
  13. GC30770 LM22B-10 An activator of TrkB and TrkC
  14. GC19362 Repotrectinib A multi-kinase inhibitor
  15. GC19332 Sitravatinib A multi-kinase inhibitor
  16. GC19063 Belizatinib An ALK inhibitor
  17. GC19012 (R)-GNE-140 (R)-GNE-140 是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂，对 LDHA 和 LDHB 的 IC50 分别为 3 nM 和 5 nM； (R)-GNE-140 的效力是 S 对映体的 18 倍。
  18. GC15365 N-Acetylserotonin The immediate precursor of melatonin
  19. GC15282 LOXO-101 (Larotrectinib) sulfate A pan-Trk inhibitor
  20. GC14476 Entrectinib A pan-Trk, ROS1, and ALK inhibitor
  21. GC16604 Altiratinib A multiple kinase inhibitor
  22. GC17622 Ro 08-2750 A p75NTR ligand
  23. GC11486 ANA 12 A TrkB receptor antagonist
  24. GC17835 LM 22A4 An agonist of TrkB
  25. GC16853 7,8-Dihydroxyflavone A TrkB kinase inhibitor
  26. GC13780 Cyclotraxin B Cyclotraxin B 是一种环状肽，是一种高效的选择性 TrkB 抑制剂，不会改变 BDNF 的结合。
  27. GC12186 BDNF (human) activator of TrkB and p75 neurotrophin receptors
  28. GC10720 NTR 368 NTR 368 是衍生自 p75 神经营养因子受体 (p75NTR) 的肽，对应于人类受体的 368-381 位残基。
  29. GC11362 K 252a A non-selective PKC inhibitor
  30. GC15271 Tyrphostin AG 879 A non-specific tyrphostin ErbB2 inhibitor
  31. GC14123 GW441756 A potent inhibitor of TrkA
  32. GC16343 GNF-5837 A pan-Trk inhibitor
  33. GC17033 Lestaurtinib A potent JAK2 and PRK1 kinase inhibitor
  34. GC11496 TLQP 21 TLQP 21 是一种 VGF 衍生肽，具有内分泌和内分泌特性，是一种有效的 G 蛋白偶联受体补体 3a 受体 1 (C3aR1) 激动剂（EC50：小鼠 TLQP 21\u003d10.3 μM；人 TLQP 21\u003d68.8 μM） .

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