HER2

HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.

Products for HER2

Cat.No. 产品名称 Information
GC13257 AC480 (BMS-599626)
AC480
A dual inhibitor of EGFR and HER2
GC10707 Afatinib dimaleate
双马来酸盐阿法替尼; BIBW 2992MA2
An inhibitor of EGFR and ErbB2
GC13296 Afatinib(BIBW2992)
阿法替尼
A selective dual inhibitor of EGFR/HER2
GC10606 BMS-599626 Hydrochloride
AC480;BMS-599626 HCl;BMS599626;BMS 599626;AC-480
BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种选择性的口服生物可利用的 HER1 和 HER2 抑制剂，IC50 分别为 20 和 30 nM。 BMS-599626 Hydrochloride 对 HER4 (IC50=190 nM) 的效力降低约 8 倍，对 VEGFR2、c-Kit、Lck、MEK 的效力超过 100 倍。 BMS-599626 Hydrochloride 抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。
GC12087 Canertinib dihydrochloride
卡纽替尼二盐酸盐,PD-183805; CI-1033;Canertinib HCl;PD183805; CI103;PD 183805; CI 103
A pan-ErbB tyrosine kinase inhibitor
GC13091 CP-724714
2-甲氧基-N-[(2E)-3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺
A selective HER2/ErbB2 tyrosine kinase inhibitor
GC16008 CUDC-101
7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺,CUDC101, CUDC 101
A multi-target inhibitor of HDACs, EGFR, and HER2
GC13608 Lapatinib
拉帕替尼; GW572016; GW2016
A dual inhibitor of EGFR and ErbB2
GC16593 Lapatinib Ditosylate
二甲苯磺酸拉帕替尼; GW572016 ditosylate monohydrate; GW2016 ditosylate monohydrate
Lapatinib Ditosylate (GW572016 ditosylate monohydrate) 是有效的 ErbB-2 和 EGFR 酪氨酸激酶结构域抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC50 值分别为 10.2 和 9.8 nM。
GC10250 Mubritinib (TAK 165)
木利替尼; TAK-165
Mubritinib (TAK 165)是一种有效的选择性 HER2/ErbB2 抑制剂，其IC₅₀为6nM。
GC10362 Neratinib (HKI-272)
来那替尼; HKI-272
A dual inhibitor of EGFR and HER2
GC17473 Pelitinib (EKB-569)
培利替尼; EKB-569; WAY-EKB 569
An EGFR receptor tyrosine kinase inhibitor
GC17916 Poziotinib
波齐替尼
An inhibitor of EGFRs
GC11172 TAK-285 A dual inhibitor of EGFR and HER2
GC15271 Tyrphostin AG 879
AG 879
A non-specific tyrphostin ErbB2 inhibitor