HER2

HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.

Cat.No. 产品名称 Information
GC13257 AC480 (BMS-599626) A dual inhibitor of EGFR and HER2
GC10707 Afatinib dimaleate An inhibitor of EGFR and ErbB2
GC13296 Afatinib(BIBW2992) A selective dual inhibitor of EGFR/HER2
GC10606 BMS-599626 Hydrochloride BMS-599626 Hydrochloride (AC480 Hydrochloride) 是一种选择性的口服生物可利用的 HER1 和 HER2 抑制剂，IC50 分别为 20 和 30 nM。 BMS-599626 Hydrochloride 对 HER4 (IC50=190 nM) 的效力降低约 8 倍，对 VEGFR2、c-Kit、Lck、MEK 的效力超过 100 倍。 BMS-599626 Hydrochloride 抑制肿瘤细胞增殖，并有可能增加肿瘤对放疗的反应。
GC12087 Canertinib dihydrochloride A pan-ErbB tyrosine kinase inhibitor
GC13091 CP-724714 A selective HER2/ErbB2 tyrosine kinase inhibitor
GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2
GC13608 Lapatinib A dual inhibitor of EGFR and ErbB2
GC16593 Lapatinib Ditosylate Lapatinib Ditosylate (GW572016 ditosylate monohydrate) 是有效的 ErbB-2 和 EGFR 酪氨酸激酶结构域抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC50 值分别为 10.2 和 9.8 nM。
GC10250 Mubritinib (TAK 165) A selective inhibitor of HER2
GC10362 Neratinib (HKI-272) A dual inhibitor of EGFR and HER2
GC17473 Pelitinib (EKB-569) An EGFR receptor tyrosine kinase inhibitor
GC17916 Poziotinib An inhibitor of EGFRs
GC11172 TAK-285 A dual inhibitor of EGFR and HER2
GC15271 Tyrphostin AG 879 A non-specific tyrphostin ErbB2 inhibitor