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ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

  1. Cat.No. 产品名称 Information
  2. GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
  3. GC66338 ROCK1-IN-1 WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
  4. GC66050 Rho-Kinase-IN-2
  5. GC63716 Sovesudil hydrochloride
  6. GC63351 Sovesudil
  7. GC63333 Cotosudil
  8. GC63253 Verosudil
  9. GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor
  10. GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
  11. GC50092 RKI 1447 dihydrochloride A ROCK1 and ROCK2 inhibitor
  12. GC50043 SR 3677 dihydrochloride A ROCK1 and ROCK2 inhibitor
  13. GC38898 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
  14. GC38791 GSK-25
  15. GC45414 CRT0066854 A PKCι and PKCζ inhibitor
  16. GC37947 Y-33075 An inhibitor of ROCK2
  17. GC37551 ROCK inhibitor-2
  18. GC37534 Ripasudil free base
  19. GC36208 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
  20. GC36207 H-1152 A ROCK inhibitor
  21. GC35442 Azaindole 1 A ROCK1 and ROCK2 inhibitor
  22. GC44847 RKI-1313 A ROCK1 and ROCK2 inhibitor
  23. GC43803 HA-1077 (hydrochloride) A ROCK inhibitor
  24. GC43286 CMPD101 A GRK2 and GRK3 inhibitor
  25. GC42747 Afuresertib (hydrochloride) A pan-Akt inhibitor
  26. GC41737 (S)-Glycyl-H-1152 (hydrochloride) A ROCK inhibitor
  27. GC34300 AR-13324 analog mesylate
  28. GC33310 Rho-Kinase-IN-1
  29. GC33120 ZINC00881524 A ROCK inhibitor
  30. GC32868 BDP5290

    BDP5290 is a potent inhibitor of ROCK and MRCK with IC50 values of 17nM, 230nM, 123nM and 100nM for MRCKβ, ROCK1, ROCK2, respectively .

  31. GC31952 ROCK-IN-1
  32. GC31883 ROCK2-IN-2
  33. GC19177 GSK180736A A ROCK1 and GRK2 inhibitor
  34. GC19034 AR-13324 mesylate AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂,已被证明可在低浓度下诱导培养的人和猪 TM 细胞的形态学变化。
  35. GC12314 3-(4-Pyridyl)indole A ROCK1 and ROCK2 inhibitor
  36. GC10716 Netarsudil (AR-13324) ROCK抑制剂
  37. GC12402 LX7101 HCL A LIMK and ROCK inhibitor
  38. GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
  39. GC16289 SAR407899 hydrochloride A ROCK1 and ROCK2 inhibitor
  40. GC16475 Afuresertib A pan-Akt inhibitor
  41. GC12817 K–115 hydrochloride dihydrate K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂,对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
  42. GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
  43. GC17712 AT13148 A multi-AGC kinase inhibitor
  44. GC13869 Fasudil Fasudil (HA-1077; AT877) 是一种非特异性 RhoA/ROCK 抑制剂,对蛋白激酶也有抑制作用,对 ROCK1 的 Ki 为 0.33 μM,对 ROCK2 和 PKA 的 IC50 分别为 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM ,PKC,PKG,分别。 Fasudil 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
  45. GC17936 GSK269962A A ROCK1 and ROCK2 inhibitor
  46. GC10722 SR-3677 A ROCK1 and ROCK2 inhibitor
  47. GC15712 Y-27632 A ROCK inhibitor
  48. GC13423 Y-39983 dihydrochloride ROCK family inhibitor
  49. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM 分别代表 ROCK2 和 PKA、PKC、PKG。 Fasudil (HA-1077) HCl 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
  50. GC18119 GSK429286A A ROCK inhibitor
  51. GC11181 Thiazovivin A ROCK inhibitor

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