ROCK(Rho相关蛋白激酶)

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

Cat.No. 产品名称 Information
GC25482 GSK269962A HCl GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
GC66338 ROCK1-IN-1 WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
GC66050 Rho-Kinase-IN-2
GC63716 Sovesudil hydrochloride
GC63351 Sovesudil
GC63333 Cotosudil
GC63253 Verosudil
GC49334 Chroman 1 (hydrochloride hydrate) A ROCK2 inhibitor
GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
GC50092 RKI 1447 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC50043 SR 3677 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC38898 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
GC38791 GSK-25
GC45414 CRT0066854 A PKCι and PKCζ inhibitor
GC37947 Y-33075 An inhibitor of ROCK2
GC37551 ROCK inhibitor-2
GC37534 Ripasudil free base
GC36208 H-1152 dihydrochloride H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
GC36207 H-1152 A ROCK inhibitor
GC35442 Azaindole 1 A ROCK1 and ROCK2 inhibitor
GC44847 RKI-1313 A ROCK1 and ROCK2 inhibitor
GC43803 HA-1077 (hydrochloride) A ROCK inhibitor
GC43286 CMPD101 A GRK2 and GRK3 inhibitor
GC42747 Afuresertib (hydrochloride) A pan-Akt inhibitor
GC41737 (S)-Glycyl-H-1152 (hydrochloride) A ROCK inhibitor
GC34300 AR-13324 analog mesylate
GC33310 Rho-Kinase-IN-1
GC33120 ZINC00881524 A ROCK inhibitor
GC32868 BDP5290
BDP5290 is a potent inhibitor of ROCK and MRCK with IC50 values of 17nM, 230nM, 123nM and 100nM for MRCKβ, ROCK1, ROCK2, respectively .
GC31952 ROCK-IN-1
GC31883 ROCK2-IN-2
GC19177 GSK180736A A ROCK1 and GRK2 inhibitor
GC19034 AR-13324 mesylate AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂，已被证明可在低浓度下诱导培养的人和猪 TM 细胞的形态学变化。
GC12314 3-(4-Pyridyl)indole A ROCK1 and ROCK2 inhibitor
GC10716 Netarsudil (AR-13324) ROCK抑制剂
GC12402 LX7101 HCL A LIMK and ROCK inhibitor
GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
GC16289 SAR407899 hydrochloride A ROCK1 and ROCK2 inhibitor
GC16475 Afuresertib A pan-Akt inhibitor
GC12817 K–115 hydrochloride dihydrate K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
GC17712 AT13148 A multi-AGC kinase inhibitor
GC13869 Fasudil Fasudil (HA-1077; AT877) 是一种非特异性 RhoA/ROCK 抑制剂，对蛋白激酶也有抑制作用，对 ROCK1 的 Ki 为 0.33 μM，对 ROCK2 和 PKA 的 IC50 分别为 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM ，PKC，PKG，分别。 Fasudil 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
GC17936 GSK269962A A ROCK1 and ROCK2 inhibitor
GC10722 SR-3677 A ROCK1 and ROCK2 inhibitor
GC15712 Y-27632 A ROCK inhibitor
GC13423 Y-39983 dihydrochloride ROCK family inhibitor
GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM 分别代表 ROCK2 和 PKA、PKC、PKG。 Fasudil (HA-1077) HCl 也是一种有效的 Ca2+ 通道拮抗剂和血管扩张剂。
GC18119 GSK429286A A ROCK inhibitor
GC11181 Thiazovivin A ROCK inhibitor