Home>>Signaling Pathways>> TGF-β / Smad Signaling>> ROCK>>(S)-Glycyl-H-1152 (hydrochloride)

(S)-Glycyl-H-1152 (hydrochloride)

目录号 GC41737

A ROCK inhibitor

规格 价格 库存 购买数量
500μg
¥1,134.00
现货
1mg
¥2,162.00
现货
5mg
¥9,072.00
现货
10mg
¥15,876.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

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产品描述

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca2+/calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC50 ≥ 10 μM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).

Chemical Properties

Cas No. 913844-45-8 SDF
别名 N/A
化学名 N/A
Canonical SMILES O=S(C1=CC=CC2=C1C(C)=CN=C2)(N3CCCN(C(CN)=O)C[C@@H]3C)=O
分子式 C18H24N4O3S•2HCl 分子量 449.4
溶解度 DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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