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(S)-Glycyl-H-1152 (hydrochloride) Sale

(Synonyms: Rho Kinase Inhibitor IV) 目录号 : GC41737

A ROCK inhibitor

(S)-Glycyl-H-1152 (hydrochloride) Chemical Structure

Cas No.:913844-45-8

规格 价格 库存 购买数量
500μg
¥1,284.00
现货
1mg
¥2,449.00
现货
5mg
¥10,278.00
现货
10mg
¥17,988.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca2+/calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC50 ≥ 10 μM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).

Chemical Properties

Cas No. 913844-45-8 SDF
别名 Rho Kinase Inhibitor IV
Canonical SMILES O=S(C1=CC=CC2=C1C(C)=CN=C2)(N3CCCN(C(CN)=O)C[C@@H]3C)=O
分子式 C18H24N4O3S•2HCl 分子量 449.4
溶解度 DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2252 mL 11.1259 mL 22.2519 mL
5 mM 0.445 mL 2.2252 mL 4.4504 mL
10 mM 0.2225 mL 1.1126 mL 2.2252 mL
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