ATM/ATR
ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.
Products for ATM/ATR
- Cat.No. 产品名称 Information
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GC69053
Elimusertib-d3
BAY 1895344-d3
Elimusertib-d3 (BAY 1895344-d3) 是 Elimusertib-d3 (BAY 1895344-d3) 的氘代物。Elimusertib 是一种有效、可口服、选择性的 ATR 抑制剂,具有抗肿瘤活性。 - GC68707 ATR-IN-4 ATR-IN-4 是一种有效的 ATR 抑制剂。ATR-IN-4 抑制人前列腺癌细胞 DU145 和人肺癌细胞 NCI-H460 的生长,IC50 分别为 130.9 nM 和 41.33 nM。(摘自专利 CN112142744A,化合物13)。
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GC25372
Elimusertib (BAY-1895344) hydrochloride
BAY-1895344 HCl
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. -
GC65514
ATR inhibitor 1
M1774; ATR inhibitor 1
ATR inhibitor 1 是一种 ATR 抑制剂,Ki 值低于 1 µμ,详细信息请参考专利 WO2015187451A1,化合物 I-l。 -
GC65327
ATM Inhibitor-5
M4076; ATM Inhibitor-5
M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines. - GC64938 AZD-7648 An inhibitor of DNA-PK
- GC64539 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
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GC64278
RP-3500
RP-3500; ATR inhibitor 4
RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM. -
GC62108
Elimusertib hydrochloride
BAY 1895344 hydrochloride
Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂,IC50 值为 7 nM,具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。 - GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
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GC34999
(S)-Ceralasertib
(S)-AZD6738
(S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。 - GC34374 BAY-1895344 hydrochloride An ATR inhibitor
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GC33420
BAY-1895344
BAY 1895344
An ATR inhibitor -
GC33404
KU 59403
KU59403是ATM的一个有效抑制剂,其IC50值为3nM。
- GC19468 AZD1390 AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂,在细胞中的 IC50 为 0.78 nM。
- GC19047 AZ32 An ATM kinase inhibitor
- GC11593 AZD0156 An ATM kinase inhibitor
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GC16941
AZD6738
AZD6738
An ATR kinase inhibitor -
GC13491
Mirin
(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮
Mirin是一种Mre11-Rad50-Nbs1(MRN)复合物抑制剂(IC50=12μM),能够抑制Mre11相关的外切酶活性,Mirin可抑制MRN依赖的ATM的激活。通常用于与DNA修复机制相关的癌症的研究。 - GC15337 VE-822 ATR抑制剂
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GC10196
ETP-46464
ATM Inhibitor III, ATR Inhibitor III
An ATR inhibitor - GC16489 CP-466722 An ATM kinase inhibitor
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GC14526
CGK733
ATM/ATR Kinase Inhibitor
An anticancer compound -
GC12054
KU-60019
KU60019;KU 60019
A potent ATM kinase inhibitor -
GC10293
VE-821
3-氨基-6-[4-(甲基磺酰基)苯基]-N-苯基-2-吡嗪甲酰胺
An inhibitor of ATR
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GC11118
KU 55933
2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮
An ATM kinase inhibitor -
GC14949
AZ20
AZ-20;AZ 20
A potent, selective ATR inhibitor -
GN10696
Garcinone C
伽升沃 C
Garcinone C 是一种黄酮衍生物,是一种从 Garcinia oblongifolia Champ 中提取的天然化合物,用作抗炎、收敛和促进肉芽的药物,对某些癌症具有潜在的细胞毒性作用。 Garcinone C 刺激 ATR 和 4E-BP1 的表达水平,同时有效抑制 cyclin B1、cyclin D1、cyclin E2、cdc2、Stat3 和 CDK7 的表达水平。 Garcinone C 以时间和剂量依赖性方式显着抑制人鼻咽癌 (NPC) 细胞系 CNE1、CNE2、HK1 和 HONE1 的细胞活力。