ATM/ATR

ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.

Cat.No. 产品名称 Information
GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
GC65514 ATR inhibitor 1
GC65327 ATM Inhibitor-5 M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.
GC64938 AZD-7648 An inhibitor of DNA-PK
GC64539 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
GC64278 RP-3500 RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
GC62108 Elimusertib hydrochloride
GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
GC34999 (S)-Ceralasertib
GC34374 BAY-1895344 hydrochloride An ATR inhibitor
GC33420 BAY-1895344 An ATR inhibitor
GC33404 KU 59403
GC19468 AZD1390 AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂，在细胞中的 IC50 为 0.78 nM。
GC19047 AZ32 An ATM kinase inhibitor
GC11593 AZD0156 An ATM kinase inhibitor
GC16941 AZD6738 An ATR kinase inhibitor
GC13491 Mirin A MRN complex inhibitor
GC15337 VE-822 ATR抑制剂
GC10196 ETP-46464 An ATR inhibitor
GC16489 CP-466722 An ATM kinase inhibitor
GC14526 CGK733 An anticancer compound
GC12054 KU-60019 A potent ATM kinase inhibitor
GC10293 VE-821
An inhibitor of ATR
GC11118 KU 55933 An ATM kinase inhibitor
GC14949 AZ20 A potent, selective ATR inhibitor
GN10696 Garcinone C Garcinone C 是一种黄酮衍生物，是一种从 Garcinia oblongifolia Champ 中提取的天然化合物，用作抗炎、收敛和促进肉芽的药物，对某些癌症具有潜在的细胞毒性作用。 Garcinone C 刺激 ATR 和 4E-BP1 的表达水平，同时有效抑制 cyclin B1、cyclin D1、cyclin E2、cdc2、Stat3 和 CDK7 的表达水平。 Garcinone C 以时间和剂量依赖性方式显着抑制人鼻咽癌 (NPC) 细胞系 CNE1、CNE2、HK1 和 HONE1 的细胞活力。