ATM/ATR
ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.
- Cat.No. 产品名称 Information
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GC25372
Elimusertib (BAY-1895344) hydrochloride
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
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GC65514
ATR inhibitor 1
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GC65327
ATM Inhibitor-5
M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.
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GC64938
AZD-7648
An inhibitor of DNA-PK
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GC64539
SKLB-197
SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
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GC64278
RP-3500
RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
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GC62108
Elimusertib hydrochloride
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GC50424
AZ 5704
Potent and selective ATM kinase inhibitor; orally bioavailable
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GC34999
(S)-Ceralasertib
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GC34374
BAY-1895344 hydrochloride
An ATR inhibitor
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GC33420
BAY-1895344
An ATR inhibitor
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GC33404
KU 59403
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GC19468
AZD1390
AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂,在细胞中的 IC50 为 0.78 nM。
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GC19047
AZ32
An ATM kinase inhibitor
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GC11593
AZD0156
An ATM kinase inhibitor
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GC16941
AZD6738
An ATR kinase inhibitor
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GC13491
Mirin
A MRN complex inhibitor
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GC15337
VE-822
ATR抑制剂
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GC10196
ETP-46464
An ATR inhibitor
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GC16489
CP-466722
An ATM kinase inhibitor
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GC14526
CGK733
An anticancer compound
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GC12054
KU-60019
A potent ATM kinase inhibitor
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GC10293
VE-821
An inhibitor of ATR
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GC11118
KU 55933
An ATM kinase inhibitor
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GC14949
AZ20
A potent, selective ATR inhibitor
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GN10696
Garcinone C
Garcinone C 是一种黄酮衍生物,是一种从 Garcinia oblongifolia Champ 中提取的天然化合物,用作抗炎、收敛和促进肉芽的药物,对某些癌症具有潜在的细胞毒性作用。 Garcinone C 刺激 ATR 和 4E-BP1 的表达水平,同时有效抑制 cyclin B1、cyclin D1、cyclin E2、cdc2、Stat3 和 CDK7 的表达水平。 Garcinone C 以时间和剂量依赖性方式显着抑制人鼻咽癌 (NPC) 细胞系 CNE1、CNE2、HK1 和 HONE1 的细胞活力。