ATM/ATR
ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.
Products for ATM/ATR
- Cat.No. 产品名称 Information
- GC69053 Elimusertib-d3 Elimusertib-d3 (BAY 1895344-d3) 是 Elimusertib-d3 (BAY 1895344-d3) 的氘代物。Elimusertib 是一种有效、可口服、选择性的 ATR 抑制剂,具有抗肿瘤活性。
- GC68707 ATR-IN-4 ATR-IN-4 是一种有效的 ATR 抑制剂。ATR-IN-4 抑制人前列腺癌细胞 DU145 和人肺癌细胞 NCI-H460 的生长,IC50 分别为 130.9 nM 和 41.33 nM。(摘自专利 CN112142744A,化合物13)。
- GC25372 Elimusertib (BAY-1895344) hydrochloride Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
- GC65514 ATR inhibitor 1 ATR inhibitor 1 是一种 ATR 抑制剂,Ki 值低于 1 µμ,详细信息请参考专利 WO2015187451A1,化合物 I-l。
- GC65327 ATM Inhibitor-5 M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.
- GC64938 AZD-7648 An inhibitor of DNA-PK
- GC64539 SKLB-197 SKLB-197 exerts selectively inhibition against ataxia telangiectasia mutated and Rad3-related (ATR) kinase with IC50 of 0.013 μM, also displays potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
- GC64278 RP-3500 RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
- GC62108 Elimusertib hydrochloride Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂,IC50 值为 7 nM,具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
- GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
- GC34999 (S)-Ceralasertib (S)-Ceralasertib 从专利 WO2011154737A1 中获取,化合物 II,IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂,具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善,并且消除 CYP3A4 时间依赖性抑制。
- GC34374 BAY-1895344 hydrochloride An ATR inhibitor
- GC33420 BAY-1895344 An ATR inhibitor
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GC33404
KU 59403
KU59403是ATM的一个有效抑制剂,其IC50值为3nM。
- GC19468 AZD1390 AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂,在细胞中的 IC50 为 0.78 nM。
- GC19047 AZ32 An ATM kinase inhibitor
- GC11593 AZD0156 An ATM kinase inhibitor
- GC16941 AZD6738 An ATR kinase inhibitor
- GC13491 Mirin A MRN complex inhibitor
- GC15337 VE-822 ATR抑制剂
- GC10196 ETP-46464 An ATR inhibitor
- GC16489 CP-466722 An ATM kinase inhibitor
- GC14526 CGK733 An anticancer compound
- GC12054 KU-60019 A potent ATM kinase inhibitor
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GC10293
VE-821
An inhibitor of ATR
- GC11118 KU 55933 An ATM kinase inhibitor
- GC14949 AZ20 A potent, selective ATR inhibitor
- GN10696 Garcinone C Garcinone C 是一种黄酮衍生物,是一种从 Garcinia oblongifolia Champ 中提取的天然化合物,用作抗炎、收敛和促进肉芽的药物,对某些癌症具有潜在的细胞毒性作用。 Garcinone C 刺激 ATR 和 4E-BP1 的表达水平,同时有效抑制 cyclin B1、cyclin D1、cyclin E2、cdc2、Stat3 和 CDK7 的表达水平。 Garcinone C 以时间和剂量依赖性方式显着抑制人鼻咽癌 (NPC) 细胞系 CNE1、CNE2、HK1 和 HONE1 的细胞活力。