Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
  3. GC49015 Phenethyl isothiocyanate An isothiocyanate with anticancer activity
  4. GC49014 Palmitoyl Tetrapeptide-7 (acetate) A cosmeceutical peptide
  5. GC49002 Sinigrin (hydrate) A glucosinolate with diverse biological activities
  6. GC48995 Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) A fluorogenic substrate of enteropeptidase
  7. GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases
  8. GC48986 9-hydroxy Stearic Acid A hydroxy fatty acid
  9. GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
  10. GC48974 Ac-VEID-AMC (ammonium acetate salt) A caspase-6 fluorogenic substrate
  11. GC48971 AZD 1152 (hydrochloride) A prodrug for a potent Aurora B inhibitor
  12. GC48969 Withanone A phytochemical with diverse biological activities
  13. GC48968 Docetaxel (hydrate) A microtubule-stabilizing agent
  14. GC62697 ZN-c3 ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.
  15. GC62657 MRIA9 MRIA9 是 ATP 竞争性的、pan-SIK 和 PAK2/3 抑制剂,其对 SIK1、SIK2 和 SIK3 的 IC50 值分别为 516 nM, 180 nM 和 127 nM。
  16. GC62594 hnRNPK-IN-1 hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体,用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis),并具有很强的抗肿瘤活性。
  17. GC62482 TAS-119 TAS-119 是一种有效的,选择性的,具有口服活性的 Aurora A 抑制剂,IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶,包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。
  18. GC62449 WEE1-IN-3 WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂,其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。
  19. GC62433 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.
  20. GC62287 EN4 EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
  21. GC62205 Maytansine An ansa macrolide with anticancer activity
  22. GC62189 CD532 hydrochloride An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
  23. GC62174 ON1231320 ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis.
  24. GC62145 Chiauranib Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
  25. GC62128 Bractoppin Bractoppin 是人 BRCA1 tBRCT 结构域识别磷酸肽的抑制剂,IC50 为 74 nM。
  26. GC62108 Elimusertib hydrochloride Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂,IC50 值为 7 nM,具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
  27. GC61870 NY2267 NY2267 是一种 Myc-Max 相互作用 (Myc-Max interaction) 干扰物,其 IC50 值为 36.5 µM。
  28. GC61831 Benproperine phosphate An antitussive agent and ARPC2 inhibitor
  29. GC61584 Vinflunine ditartrate

    Vinflunineditartrate是一种长春花生物碱家族的氟化微管抑制剂。Vinflunineditartrate具有抗血管生成,破坏血管和抗转移的活性。Vinflunineditartrate可用于尿路上皮移行细胞癌,非小细胞肺癌和乳腺癌的研究。

  30. GC61400 MAP4343 MAP4343是Pregnenolone的3-甲基醚衍生物。MAP4343在体外与微管相关蛋白2(MAP2)结合,刺激微管蛋白的聚合,增强神经突的延伸并保护神经元免受神经毒性剂的侵害。
  31. GC19528 1,4-Benzoquinone A toxic metabolite of benzene
  32. GC48901 BRD9876 An Eg5 inhibitor
  33. GC48848 Albendazole-d7 An internal standard for the quantification of albendazole
  34. GC48764 Sydowinin B A xanthone polyketide with immunosuppressant activity
  35. GC48721 6-O-Demethyl Griseofulvin A metabolite of griseofulvin
  36. GC48720 Griseofulvic Acid A metabolite of griseofulvin
  37. GC48688 Griseofulvin-d3 An internal standard for the quantification of griseofulvin
  38. GC48659 Umbelliprenin A prenylated coumarin with diverse biological activities
  39. GC48652 Olomoucine II A CDK inhibitor
  40. GC48471 Z-(L-Arg)-AMC (hydrochloride) A fluorogenic substrate for trypsin, cathepsin B, and cathepsin H
  41. GC48470 Ac-DEVD-CHO (trifluoroacetate salt) A dual caspase-3/caspase-7 inhibitor
  42. GC48423 19-O-Acetylchaetoglobosin A A fungal metabolite with actin polymerization inhibitory and cytotoxic activities
  43. GC48401 Risuteganib (trifluoroacetate salt) An anti-integrin peptide
  44. GC48394 Phomopsinamine An inhibitor of microtubule polymerization
  45. GC48387 Inostamycin A A bacterial metabolite with anticancer activity
  46. GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan
  47. GC48119 Suprafenacine An inhibitor of tubulin polymerization with anticancer activity
  48. GC48101 SSAA09E1 A SARS-CoV entry inhibitor
  49. GC48092 Spinosad A naturally-occurring insecticide
  50. GC48084 Sodium 4-Phenylbutyrate-d11 An internal standard for the quantification of sodium 4-phenylbutyrate
  51. GC48076 Sesquicillin A A fungal metabolite

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