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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC46347 (S)-(+)-Methoprene An insect growth regulator and Met agonist
  3. GC46335 (E)-Fenpyroximate A phenoxypyrazole acaricide
  4. GC61314 Taltobulin hydrochloride Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物，Taltobulin是一种有效的抗微管剂(antimicrotubule)，可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡(apoptosis)。
  5. GC61072 MK-28 MK-28是有效、选择性的PERK激动剂。MK-28在小鼠中表现出良好的药代动力学特征，且能透过血脑屏障。
  6. GC61043 Mesalamine impurity P MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
  7. GC61014 Lusianthridin Lusianthridin是来自Dendrobiumvenustum的天然化合物，具有抗迁移作用。Lusianthridin通过抑制Src-STAT3信号，促进c-Myc的降解。
  8. GC60891 GW406108X GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
  9. GC60688 Cereblon modulator 1 A modulator of cereblon
  10. GC60621 Batabulin sodium An inhibitor of tubulin polymerization
  11. GC60620 Batabulin An inhibitor of tubulin polymerization
  12. GC60259 MYCMI-6 MYCMI-6 (NSC354961) 是一种有效的选择性内源性 MYC:MAX 蛋白相互作用抑制剂。 MYCMI-6 阻断 MYC 驱动的转录。MYCMI-6 选择性结合 MYC bHLHZip 域，Kd 值为 1.6 μM。MYCMI-6 以 MYC 依赖性的方式抑制肿瘤细胞的生长 (IC50<0.5 μM)。MYCMI-6 对正常人细胞无细胞毒性。MYCMI-6 诱导细胞凋亡 (apoptosis)。
  13. GC60143 DM3 DM3 (Maytansinoid DM3) 是一种带有二硫键或硫醇基的美登素类似物，是一种 tubulin 的抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分。
  14. GC39798 Scoulerine A benzylisoquinoline alkaloid with diverse biological activities
  15. GC39558 Tubulin inhibitor 6 An inhibitor of tubulin polymerization and a PP2A activator
  16. GC39486 DCLK1-IN-1 DCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively.
  17. GC50599 P110 Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
  18. GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor
  19. GC50529 Surfen Surfen 是一种有效的 HS（硫酸乙酰肝素）拮抗剂。
  20. GC50439 Peptide5 Peptide5 是一种连接蛋白 43 模拟肽，可减少脊髓损伤后动物肿胀、星形胶质细胞增生和神经元细胞死亡体外:Peptide5 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。
  21. GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
  22. GC50397 Flutax 2 绿色荧光紫杉醇衍生物；结合微管
  23. GC50370 AZ 13705339 AZ 13705339 是一种高效的选择性 PAK1 抑制剂，对 PAK1 和 pPAK1 的 IC50 分别为 0.33 nM 和 59 nM。 AZ 13705339 与 PAK1 和 PAK2 具有结合亲和力，Kds 分别为 0.28 nM 和 0.32 nM。 AZ 13705339 可用于癌症研究。
  24. GC50314 PF 3758309 dihydrochloride An inhibitor of PAK4
  25. GC50214 LCB 03-0110 dihydrochloride Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
  26. GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
  27. GC50145 CHR 6494 trifluoroacetate A selective Haspin protein kinase inhibitor
  28. GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
  29. GC50110 Mps1-IN-1 dihydrochloride A selective Mps1 kinase inhibitor
  30. GC50092 RKI 1447 dihydrochloride A ROCK1 and ROCK2 inhibitor
  31. GC50056 UA 62784 Inhibits microtubule polymerization
  32. GC50052 Laulimalide

    Microtubule stabilzing agent
  33. GC50050 Hesperadin hydrochloride A multi-kinase inhibitor
  34. GC50045 PD 166285 dihydrochloride A tyrosine kinase inhibitor
  35. GC50043 SR 3677 dihydrochloride A ROCK1 and ROCK2 inhibitor
  36. GC50020 Dynamin inhibitory peptide, myristoylated DynaMin inhibitory peptide, myristoylated 是一种 DynaMin 抑制剂，可干扰两性霉素与 dynamin 的结合。
  37. GC39209 LCH-7749944 LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.
  38. GC46224 S-Phenylcysteine An adduct
  39. GC46219 Satratoxin H A trichothecene mycotoxin
  40. GC46218 Satratoxin G A macrocyclic trichothecene mycotoxin
  41. GC46210 Quinacrine mustard (hydrochloride) A fluorescent DNA-intercalating agent
  42. GC46196 Pal-KTTKS (acetate) A lipidated pentapeptide
  43. GC46190 NSC 15520 An inhibitor of RPA70 dsDNA binding
  44. GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate
  45. GC39177 Valecobulin hydrochloride Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂 (VDA), 是一种强效的、β-微管蛋白聚合抑制剂，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
  46. GC39156 AMG PERK 44 AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。
  47. GC38945 S516 S516 (Compound 22) 是 CKD-516 的活性代谢产物，是一种有效的微管蛋白聚合抑制剂，其 IC50 值为 4.29 μM。S516 具有显著的抗肿瘤活性。
  48. GC38898 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
  49. GC46019 Pluviatolide A lignan
  50. GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone
  51. GC45958 Myrothecine A A trichothecene mycotoxin

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