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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC45944 para-amino-Blebbistatin A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility
  3. GC38845 sAJM589 sAJM589 是一种 Myc 抑制剂，能干扰 Myc- max 异二聚体的形成，其 IC50 值为 1.8 μM。
  4. GC38791 GSK-25 GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。
  5. GC38783 Ginkgolic acid C17:1 A phenolic acid with antibacterial and anticancer activities
  6. GC45903 Quazinone A PDE3 inhibitor
  7. GC45890 (+)-Abscisic Acid-d6 An internal standard for the quantification of (+)-abscisic acid
  8. GC45877 CYM 5478 An S1P2 agonist
  9. GC45846 PKUMDL-LC-101-D04 An allosteric activator of GPX4
  10. GC45833 N-Oleoyl-L-phenylalanine An N-acyl amide
  11. GC45809 AMG-Tie2-1 A Tie2 and VEGFR2 inhibitor
  12. GC45798 Rhein-13C4 An internal standard for the quantification of rhein
  13. GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
  14. GC45769 Vandetanib-d6 An internal standard for the quantification of vandetanib
  15. GC45758 Paclitaxel octadecanedioate A prodrug form of paclitaxel
  16. GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) An actin-sequestering peptide
  17. GC45744 monoMICAAc A solvatochromic fluorescent pH probe
  18. GC45743 ICAAc A solvatochromic fluorophore and pH probe
  19. GC45688 STX140 An estrogen sulfamate
  20. GC45680 Prodan A solvatochromic fluorescent probe
  21. GC45668 Gly-Arg-AMC (hydrochloride) A fluorogenic substrate for cathepsin C
  22. GC45667 N-(p-Tosyl)-GPR-pNA (acetate) A colorimetric thrombin substrate
  23. GC45639 Hexapeptide-11 (acetate) A synthetic hexapeptide
  24. GC45616 C6 Urea Ceramide An inhibitor of neutral ceramidase
  25. GC38589 MYCi361 MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
  26. GC38588 MYCi975 MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.
  27. GC38564 Deoxypodophyllotoxin A flavolignan with diverse biological activities
  28. GC38519 Ilorasertib hydrochloride A multi-kinase inhibitor
  29. GC38480 Vat-Cit-PAB-Monomethyl Dolastatin 10 Vat-Cit-PAB-Monomethyl Dolastatin 10 是抗体-药物偶联物的一部分，由 Monomethyl Dolastatin 10 (一种有效的微管蛋白抑制剂) 和 ADC linker Vat-Cit-PAB 连接而成。
  30. GC38468 DM4-SMe DM4-SMe 是抗体-美登素偶联物 (AMC) 的代谢产物，是一种微管蛋白 (tubulin) 抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM4-SMe 抑制 KB 细胞的增殖，IC50 值为 0.026 nM。
  31. GC38460 DM4-SPDP DM4-SPDP 是由连接桥 SPDP 和 毒性分子 DM4 连接而成的，可用来制备抗体偶联药物。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂，可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可裂解的 (可还原的) 二硫键，实现胺与巯基的结合。
  32. GC38456 Pironetin An inhibitor of microtubule assembly
  33. GC38410 Vincristine An antimitotic inhibitor of tubulin polymerization
  34. GC38403 LDN-192960 hydrochloride An inhibitor of haspin and DYRK2
  35. GC38397 MMAF sodium An auristatin with anticancer activity
  36. GC38355 DM3-SMe DM3-SMe 是一种美登素衍生物，是一种微管蛋白 (tubulin) 抑制剂，是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM3-SMe 在体外显示出高度的细胞毒性活性，IC50 为 0.0011 nM。
  37. GA23742 Z-D-Arg-Gly-Arg-pNA . 2 HCl A colorimetric Factor Xa substrate
  38. GA23633 T-Peptide T-peptide 是一种 Tuftsin 类似物，可用于人类免疫缺陷病毒 (HIV) 感染的研究。
  39. GA23570 Suc-Tyr-Val-Ala-Asp-pNA A colorimetric caspase-1 and -4 substrate
  40. GA23337 Oxythiamine . HCl A thiamine antimetabolite
  41. GA22303 H-D-Pro-Phe-Arg-pNA . 2 HCl A colorimetric plasma kallikrein substrate
  42. GA21951 H-4-Nitro-Phe-OEt . HCl A building block
  43. GA21397 Dolastatin 15 A peptide with anticancer activity
  44. GA20494 Ac-Asp-Glu-Val-Asp-pNA A colorimetric caspase substrate
  45. GC45595 Vulpinic Acid A lichen metabolite with diverse biological activities
  46. GC45552 Pyrenophorol A fungal metabolite with diverse biological activities
  47. GC45538 Oxychlororaphine A microbial metabolite with diverse biological activities
  48. GC45534 OH-Chol A cationic cholesterol derivative
  49. GC45523 Nemorosone A PPAP with antiproliferative properties
  50. GC45515 MX1013 A dipeptide pan-caspase inhibitor
  51. GC45471 H-Gly-Arg-pNA (hydrochloride) A colorimetric thrombin substrate

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