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Podophyllotoxin-d6 Sale

(Synonyms: PPT-d6) 目录号 : GC49077

An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin

Podophyllotoxin-d6 Chemical Structure

规格 价格 库存 购买数量
500 µg
¥1,696.00
现货
1 mg
¥3,221.00
现货
5 mg
¥12,728.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Podophyllotoxin-d6 is intended for use as an internal standard for the quantification of podophyllotoxin and picropodophyllotoxin by GC- or LC-MS. Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.1,2,3,4,5 It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM) and induces mitotic arrest at the G2/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 µg/ml.2,3 Podophyllotoxin (5 µM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells.4 It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC50s = 0.0098-0.017 µM).5 Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide and teniposide .6 Formulations containing podophyllotoxin have been used in the treatment of external genital warts.

1.Imbert, T.F.Discovery of podophyllotoxinsBiochimie80(3)207-222(1998) 2.Loike, J.D., Brewer, C.F., Sternlicht, H., et al.Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congenersCancer Res.38(9)2688-2693(1978) 3.Krishan, A., Paika, K., and Frei, E., IIICytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblastsJ. Cell Biol.66(3)521-530(1975) 4.Hammonds, T.R., Denyer, S.P., Jackson, D.E., et al.Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubulesJ. Med. Microbiol.45(3)167-172(1996) 5.StrÖmberg, T., Feng, X., Delforoush, M., et al.Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cellsMed. Oncol.32(7)188(2015) 6.Xu, H., Lv, M., and Tian, X.A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007Curr. Med. Chem.16(3)327-349(2009)

Chemical Properties

Cas No. N/A SDF
别名 PPT-d6
Canonical SMILES O=C1[C@]2([H])[C@@](C3=CC(OC([2H])([2H])[2H])=C(C(OC)=C3)OC([2H])([2H])[2H])([H])C4=CC(OCO5)=C5C=C4[C@@H]([C@@]2([H])CO1)O
分子式 C22H16D6O8 分子量 420.4
溶解度 Acetonitrile: soluble,DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mM 2.3787 mL 11.8934 mL 23.7869 mL
5 mM 0.4757 mL 2.3787 mL 4.7574 mL
10 mM 0.2379 mL 1.1893 mL 2.3787 mL
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