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Fisetin-d5 Sale

目录号 : GC49344

An internal standard for the quantification of fisetin

Fisetin-d5 Chemical Structure

规格 价格 库存 购买数量
1 mg
¥1,525.00
现货
5 mg
¥6,476.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Fisetin-d5 is intended for use as an internal standard for the quantification of fisetin by GC- or LC-MS. Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.1,2,3,4 It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-Formyl-Met-Leu-Phe in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM.1,3 Fisetin (10-60 µM) induces cell cycle arrest at the G1 phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells.2 It inhibits LPS-induced production of nitrite, prostaglandin E2 , and NF-κB activation in RAW 264.7 cells.3 Fisetin (1 mg/animal) reduces tumor growth in a CWR22RΥ1 prostate cancer mouse xenograft model.4

1.Khan, N., Syed, D.N., Ahmad, N., et al.Fisetin: A dietary antioxidant for health promotionAntioxid. Redox Signal.19(2)151-162(2013) 2.Khan, N., Afaq, F., Syed, D.N., et al.Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cellsCarcinogenesis29(5)1049-1056(2008) 3.Wang, L., Tu, Y.-C., Lian, T.-W., et al.Distinctive antioxidant and antiinflammatory effects of flavonolsJ. Agric. Food Chem.54(26)9798-9804(2006) 4.Khan, N., Asim, M., Afaq, F., et al.A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude miceCancer Res.68(20)8555-8563(2008)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES O=C1C2=C(C([2H])=C(O)C([2H])=C2)OC(C3=C([2H])C(O)=C(O)C([2H])=C3[2H])=C1O
分子式 C15H5D5O6 分子量 291.3
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 3.4329 mL 17.1644 mL 34.3289 mL
5 mM 0.6866 mL 3.4329 mL 6.8658 mL
10 mM 0.3433 mL 1.7164 mL 3.4329 mL
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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% DMSO % % Tween 80 % saline
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