NF-κB
NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.
- Cat.No. 产品名称 Information
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GC40266
(+)-Praeruptorin A
A coumarin derivative
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GC40264
(+)-Valencene
A sesquiterpene
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GC32705
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin)
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (Dehydroxymethylepoxyquinomicin) 是一种有效、选择性和不可逆的 NF-κB 抑制剂,可与半胱氨酸残基共价结合。
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GC61564
(E/Z)-IT-603
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603. IT-603 is a NF-κB family member c-Rel inhibitor with an IC50 of 3 μM in electrophoretic mobility shift assay (EMSA).
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GC13030
(R)-(-)-Ibuprofen
A less potent enantiomer of ibuprofen
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GC69823
(R)-(-)-Ibuprofen-d3
(R)-(-)-Ibuprofen-d3 是 (R)-(-)-Ibuprofen 的氘代物。(R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体,对 COX 无作用,可以抑制 NF-κB 的活化;(R)-(-)-Ibuprofen 具有抗炎作用,可用于缓解疼痛的研究。
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GC39321
(Rac)-Myrislignan
(Rac)-Myrislignan 是Myrislignan 的外消旋体。 Myrislignan 是从Myristica fragrans Houtt 分离得到的一种木酚素,具有抗炎活性。Myrislignan 通过抑制NF-kB信号通路的激活,减轻LPS诱导的小鼠巨噬细胞炎症反应。
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GC10821
11-keto-β-Boswellic Acid
A 5-LO inhibitor
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GC40763
14-deoxy-11,12-didehydro Andrographolide
A noncytotoxic natural diterpenoid
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GC68044
2,4,6-Trihydroxybenzaldehyde
2,4,6-Trihydroxybenzaldehyde 是一种具有口服活性的 NF-?B 抑制剂。2,4,6-Trihydroxybenzaldehyde 具有抗肿瘤活性、抗癌细胞增殖活性和抗肥胖活性。
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GC39325
2,5-Dihydroxyacetophenone
2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
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GC60467
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione是delta9,11类固醇类合成的中间体(intermediate),如Vamorolone 。delta9,11steroids是糖皮质激素的修饰后的产物,具有抗炎(anti-inflammatory)特性。delta9,11类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。
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GC42406
4'-hydroxy Chalcone
A chalcone metabolite with diverse biological activities
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GC38663
4-Hydroxychalcone
A chalcone metabolite with diverse biological activities
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GC35143
4-O-Methyl honokiol
A phenol with diverse biological activities
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GC52413
5-Aminosalicylic Acid-d7
An internal standard for the quantification of 5-aminosalicylic acid
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GC35185
7,4'-Dihydroxyflavone
A flavonoid with diverse biological activities
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GC35199
8-Deoxygartanin
8-Deoxygartanin 是山竹果中的一种 prenylated xanthones。8-Deoxygartanin 是一种丁基胆碱酯酶 (BChE) 的选择性抑制剂。8-Deoxygartanin 具有抗疟原虫活性,对 Plasmodium falciparum W2 植株作用的 IC50 值为 11.8 μM。8-Deoxygartanin 能抑制 NF-κB (p65) 的活化,IC50 值为 11.3 μM。
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GN10212
8-O-Acetyl shanzhiside methyl ester
8-O-Acetyl shanzhisidemethylester (8-O-Acetyl shanzhisidemethylester) 是一种环烯醚萜苷,从西藏的一种民间药用植物Lamiophlomis rotata Kudo 的叶子中分离得到。
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GC15598
Ac2-26
An annexin A1-mimetic peptide
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GC35224
Ac2-26 TFA
Ac2-26 TFA,是膜联蛋白 A1 (AnxA1) 的活性 N-末端肽,可减轻缺血再灌注诱导的急性肺损伤。Ac2-26 还降低 AnxA1 蛋白表达,抑制受损肺组织中 NF-κB 和 MAPK 通路活化。
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GN10536
Aconine
An active metabolite of aconitine
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GC31693
Adelmidrol
Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.
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GC67968
ALPK1-IN-2
ALPK1-IN-2 (化合物 T001) 是一种有效的 ALPK1 (α- 激酶 1) 抑制剂,其 IC50 值为 95 nM。ALPK1-IN-2 还抑制 NF-κB,IC50 值为 1.31 μM。
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GC39254
Anatabine dicitrate
Anatabine dicitrate 是一种烟草生物碱,可以穿过血脑屏障。Anatabine dicitrate 是一种有效的 α4β2 nAChR 激动剂。Anatabine dicitrate 通过阻止淀粉样蛋白前体蛋白的 β 裂解,抑制 NF-κB 激活,并降低淀粉样 β (Aβ) 的产生。Anatabine dicitrate 具有抗炎作用,可用于神经退行性疾病的研究。
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GN10718
Andrographolide
An inhibitor of NF-κB signaling
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GC35340
Andropanolide
Andrographolide (Andro) 穿心莲内酯是通过共价修饰 p50 的半胱氨酸 62 来影响 NF-κB 活性的小拮抗剂。Andrographolide (Andro) 穿心莲内酯是一种双环二萜内酯,主要由穿心莲 (Andrographis paniculate) 产生。Andrographolide (Andro) 穿心莲内酯抑制刺激的内皮细胞中 NF-κB 的活化,降低细胞粘附分子 E-选择素的表达,阻止 E-选择素介导的白细胞粘附,但对 IκBα 降解,p50 和 p65 核转位没有影响。
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GN10685
Anemarsaponin B
Anemarsaponin B 是一种甾体皂苷。
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GN10579
Aristolochic Acid A
A PLA2 inhibitor
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GC35394
Armepavine
Armepavine 是一种来自 Nelumbo nucifera 的活性化合物,不仅对人外周血单核细胞具有抗炎作用,且对 T 淋巴细胞和狼疮肾炎小鼠也具有免疫抑制作用。Armepavine 抑制 TNF-α 诱导的 MAPK 和 NF-κB 信号级联反应。
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GC35401
Asatone
Asatone 是从细辛中分离到的一种活性成分,具有抗炎活性,通过活化 NF-κB 及下调 p-MAPK (ERK,JNK 和 p38) 通路起作用。
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GC35412
Asperulosidic Acid
Asperulosidic Acid (ASPA) 车叶草苷酸是一种具有生物活性的环烯醚萜苷,从白花蛇舌草 (Hedyotis diffusa Willd) 的草药中提取的。 Asperulosidic Acid (ASPA) 具有抗肿瘤,抗氧化和抗炎作用。Asperulosidic Acid (ASPA) 通过抑制 NF-κB 和丝裂原活化蛋白激酶 (MAPK) 信号通路抑制炎性细胞因子(TNF-α,IL-6) 释放发挥抗炎作用。
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GN10415
Astilbin
A flavonoid with diverse biological activities
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GC42880
Avenanthramide-C methyl ester
Inhibitor of NF-κB activation
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GC39280
B022
B022 是一种有效的选择性的 NF-κB 诱导激酶 (NIK) 抑制剂,Ki 为 4.2 nM。B022 可保护肝脏免受毒素引起的炎症,氧化应激和伤害。
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GN10018
Baicalin
A flavonoid with diverse biological activities
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GC10345
Bay 11-7085
An irreversible inhibitor of IκBα phosphorylation
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GC13035
Bay 11-7821
A selective and irreversible NF-κB inhibitor
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GC35494
Benzoyloxypaeoniflorin
Benzoyloxypaeoniflorin 分离于 Paeonia suffruticosa 的根,是 tyrosinase 抑制剂,对蘑菇 tyrosinase 的 IC50为 0.453 mM。Benzoyloxypaeoniflorin 是 NF-κB 抑制剂,Benzoyloxypaeoniflorin 通过对血小板聚集和凝血的抑制作用,有助于改善血液循环。
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GN10443
Berbamine
A bisbenzylisoquinoline alkaloid with diverse biological activities
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GN10358
Berbamine hydrochloride
A bisbenzylisoquinoline alkaloid with diverse biological activities
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GC10480
Betulinic acid
A plant triterpenoid similar to bile acids
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GC65010
Bortezomib-d8
Bortezomib-d8 (PS-341-d8) 是 Bortezomib 的氘代物。Bortezomib (PS-341) 是一种可逆性和选择性的蛋白酶体 (proteasome) 抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki=0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是第一种蛋白酶体抑制剂,具有抗癌活性。
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GC40352
Cafestol
A natural diterpene which increases serum cholesterol
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GC10692
Caffeic Acid Phenethyl Ester
A potent inhibitor of NF-κB activation
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GC18069
Cardamonin
A chalconoid with anti-inflammatory and anti-tumor activity
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GC43165
CAY10512
A potent inhibitor of NF-κB
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GC41601
CAY10591
A SIRT1 activator
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GC43190
CAY10682
A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
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GC15394
CBL0137 (hydrochloride)
An activator of p53 and inhibitor of NF-κB