NF-κB

Cat.No. 产品名称 Information

GN10584 Ginsenoside Rk1 人参皂甙 Rk1 是通过在高温下加工人参植物（主要是 Sung Ginseng，SG）而产生的独特成分。

GC31817 Ginsenoside Rk3 GinsenosideRk3存在于Panaxnotoginseng的根中。在HepG2细胞中GinsenosideRk3抑制TNF-α诱导的NF-κB转录活性，IC50值为14.24±1.30μM。

GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects

GC60180 Gossypin A flavonoid glycoside with diverse biological activities

GC43786 GS-143 An inhibitor of IκBα ubiquitylation

GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.

GC69216 HE 3286 HE 3286 是天然抗炎类固醇 β-AET 的合成衍生物。HE 3286 是具有口服活性的 NF-κB 部分抑制剂。HE 3286 降低了促炎信号，包括 IL-6 和基质金属肽酶 3。HE 3286 可自由穿过小鼠血脑屏障。HE 3286 可用于溃疡性结肠炎、关节炎、实验性自身免疫性脑脊髓炎的研究。

GC43810 Helenalin An anti-inflammatory sesquiterpene lactone

GC60897 Hesperidin methylchalcone Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity.

GC31692 Homoplantaginin A flavonoid glycoside with antioxidant and anti-inflammatory activities

GC36301 IKKγ NBD Inhibitory Peptide IKKγ NBD Inhibitory Peptide是 NEMO 结合域的多肽，对应着 NEMO 氨基端α螺旋区，可以阻断 TNFα 诱导的 NF-kB 激活。

GC16368 Indole-3-carbinol A natural phytochemical

GC33861 Inulicin (1-O-Acetylbritannilactone) A sesquiterpene lactone with diverse biological activities

GC39109 Isodeoxyelephantopin Isodeoxyelephantopin 是一种倍半萜烯内酯，可从Elephantopus scaber 中分离得到。Isodeoxyelephantopin 可诱导活性氧的生成，抑制NF-κB 的激活。Isodeoxyelephantopin 还能调节LncRNA 的表达，有抗乳腺癌的作用。

GC39095 Isoliquiritin apioside Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

GC41273 Isoquercetin A flavonoid with diverse biological activities

GN10804 Isovitexin A C-glycosylated flavone with diverse biological activities

GC33844 Isovitexin (Saponaretin) A C-glycosylated flavone with diverse biological activities

GC11438 JSH-23 An inhibitor of NF-κB translocation

GC39093 Kamebakaurin

Kamebakaurin, a compound of kaurane diterpenes was isolated from traditional Chinese medicinal plant Isodon excia.

GC44085 L-Sulforaphene A natural isothiocyanate

GC10474 Laquinimod (ABR-215062) An immunomodulator

GC36446 Licochalcone D Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.

GC36456 Licoricidin Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，是一种对抗结直肠癌的潜在化学预防或化学治疗剂。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。

GC17608 Lidocaine An Analytical Reference Standard

GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) An Analytical Reference Standard

GC61021 Malachite green oxalate Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity.

GN10491 Mangiferin A xanthone glucoside with diverse biological activities

GC17632 Maslinic Acid A biologically active triterpene

GC16607 Mesalamine An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine

GC61043 Mesalamine impurity P MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。

GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram

GC16007 Methylthiouracil 甲基硫氧嘧啶是一种抗甲状腺药物。

GC44238 Mn(III)TBAP A cell-permeable SOD mimic

GN10436 Morusin A prenylated flavonoid with diverse biological activities

GC17279 N-3-oxo-dodecanoyl-L-Homoserine lactone

N-3-氧代-十二烷酰基-L-单丝氨酸内酯（3-氧代-C12-HSL）作为胃肠道中革兰氏阴性菌产生的群体感应（QS）分子，是由高水平的细胞内活性氧（ROS）指示的氧化应激的主要诱导剂。

GC36696 Naringin Dihydrochalcone A flavonoid with antioxidant activity

GC69539 Nasunin Nasunin 是一种抗氧化花青素、具有抗血管生成活性。

GC44353 NDMC101 A salicylanilide derivative

GN10103 Neferine An alkaloid with diverse biological activities

GN10429 Neochlorogenic acid A phenolic compound with diverse biological activities

GC60267 Neocryptotanshinone Neocryptotanshinone是可从SalviaMiltiorrhiza分离得到的一种丹参二萜，通过抑制NF-κB和iNOS信号来抑制LPS诱导的炎症。

GC48985 NF-κB Inhibitor (trifluoroacetate salt) A cell-permeable peptide that blocks nuclear import of NF-κB

GC69555 NF-κB-IN-4 NF-κB-IN-4 (化合物 17) 是一种有效的可透过血脑屏障的 NF-κB 通路抑制剂。NF-κB-IN-4 表现出潜在的低毒性抗神经炎症活性。NF-κB-IN-4 可阻断 IκBα 的激活和磷酸化，降低 NLRP3 的表达，从而抑制 NF-κB 的激活。NF-κB-IN-4 可用于神经炎症相关疾病的研究。

GC69556 NF-κB/MAPK-IN-1 NF-κB/MAPK-IN-1 (compound 11a) 是一种有效的 NF-κB 和 MAPK 通路抑制剂。NF-κB/MAPK-IN-1 对 NO 生成具有抑制作用，其 IC50 为6.96 μM。NF-κB/MAPK-IN-抑制 LPS 诱导的 iNOS，COX-2，ERκ 和 P38 激活。 NF-κB/MAPK-IN-1 可抑制 LPS 诱导的巨噬细胞炎症反应。 NF-κB/MAPK-IN-1 可用于类风湿关节炎 (RA) 的研究。

GC11736 NF-κB Activation Inhibitor III An inhibitor of NF-κB activation

GC31733 NIK SMI1

NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.

GC36794 Okanin Okanin 是 Coreopsis tinctoria 的有效成分。Okanin 通过抑制 TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。

GN10756 Ophiopogonin D A steroid glycoside with diverse biological activities

GC12114 Oxaprozin An NSAID and COX inhibitor

Products for NF-κB