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NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

Products for  NF-κB

  1. Cat.No. 产品名称 Information
  2. GC35629 CDDO-dhTFEA CDDO-dhTFEA (RTA dh404) 是一种合成的齐墩果烷三萜化合物,有效激活 Nrf2 并抑制促炎转录因子 NF-κB。 CDDO-dhTFEA 可以恢复高血压 (MAP),增加 Nrf2 及其靶基因的表达,减弱 NF-κB 的活化和转化生长因子-β 途径,并减少慢性肾病 (CKD) 大鼠的肾小球硬化,间质纤维化和炎症。
  3. GC52081 Chamazulene A terpene with anti-inflammatory and antioxidant activities
  4. GC31886 Chelidonic acid A pyran with diverse biological activities
  5. GC12532 CHPG A potent and selective mGluR5 agonist
  6. GC17963 CHPG Sodium salt CHPG 钠盐是一种选择性 mGluR5 激动剂,可通过 BV2 小胶质细胞中的 TSG-6/NF-κB 通路减弱 SO2 诱导的氧化应激和炎症。
  7. GC17873 CID-2858522 A selective inhibitor of NF-κB activation
  8. GC39701 Convallatoxin Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物,并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂,具有很高的效力和功效。具有抗炎和抗增殖特性。
  9. GN10409 cor-nuside A bisiridoid glycoside with diverse biological activities
  10. GN10442 Curculigoside 仙茅苷是 C. 中的主要皂苷。
  11. GC30806 Cyclo(his-pro) (Cyclo(histidyl-proline)) A cyclic neuropeptide and metabolite of TRH
  12. GC38761 Cyclo(his-pro) TFA Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) 是一种具有口服活性的,结构上与促甲状腺激素释放激素相关的环状二肽。Cyclo(his-pro) TFA 可以抑制 NF-κB 核积累。Cyclo(his-pro) TFA 可以穿越脑血屏障并影响多种炎症和应激反应。
  13. GN10178 Cyclohexanecarboxylicacid A phenolic acid
  14. GC33330 Cynaropicrin A sesquiterpene lactone
  15. GC38182 Dauricine Dauricine, a plant metabolite isolated from the Asian vine Menispermum dauricum, plays a variety of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents.Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF‐κB signaling pathway in colon cancer cells.
  16. GC38184 Dehydrodiisoeugenol Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.
  17. GC38431 Dehydroevodiamine An alkaloid with diverse biological activities
  18. GC38101 Demethyleneberberine

    Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.

  19. GC68961 Demethyleneberberine chloride Demethyleneberberine chloride 是一种天然线粒体靶向抗氧化剂。Demethyleneberberine chloride 通过抑制 NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。Demethyleneberberine chloride 可作为 AMPK 激活剂,用于非酒精性脂肪性肝病 (NAFLD) 的研究。
  20. GC34556 Dendrophenol Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.
  21. GC60129 Deoxyelephantopin Deoxyelephantopin是一种来自Elephantopusscaber的,具有生物活性的天然倍半萜烯内酯。可广泛用于癌症方面的研究。Deoxyelephantopin抑制NF-κB,MAPK,PI3K/Akt和β-catenin信号传导。
  22. GC33150 DHMEQ racemate (rel-DHMEQ) DHMEQ 消旋体 (rel-DHMEQ) 是一种 NF-κB 抑制剂。 DHMEQ 消旋体 (rel-DHMEQ) 的活性低于 (-)-DHMEQ。
  23. GN10056 Dihydroartemisinin An antimalarial compound
  24. GC52194 Dimethylamino Parthenolide An inhibitor of NF-κB
  25. GC43498 DL-α-Lipoic Acid An important decarboxylation cofactor and antioxidant
  26. GC34901 DMAPT DMAPT(DimethylaminoParthenolide)是Parthenolide(PTL)的水溶性类似物,是具有口服活性的NF-κB抑制剂,对原发性急性髓性白血病细胞的LD50值为1.7μM。具有潜在的抗肿瘤和抗转移作用。
  27. GC31557 Edasalonexent (CAT-1004) Edasalonexent (CAT-1004) (CAT-1004) 是一种口服生物可利用的 NF-κB 抑制剂。
  28. GC16044 Emodin Natural CK2 inhibitor and ER agonist
  29. GN10646 Engeletin A flavonoid glycoside with diverse biological activities
  30. GC43611 Enniatin B1 An antibiotic ionophore
  31. GC18046 Erdosteine A mucolytic agent and an antioxidant
  32. GC38637 Ergolide Ergolide 是一种从大黄菊 (Inula Britannica) 的干燥花中分离出的倍半萜内酯。Ergolide 通过使 NF-κB 失活抑制 RAW 264.7 巨噬细胞中诱导的一氧化氮合酶和环加氧酶 2 的表达。
  33. GC36006 Esculentoside H Esculentoside H (EsH) 是从多年生植物 Phytolacca esculent 的根提取物中分离和纯化的水溶性皂苷。Esculentoside H (EH) 具有抗肿瘤活性,其机制与 TNF 释放能力有关。Esculentoside H (EsH) 通过阻断 JNK1/2 和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达抑制结肠癌细胞迁移。
  34. GN10004 EsculentosideA EsculentosideA (EsA),一种从商陆根中分离得到的三萜皂苷。
  35. GC10519 Ethacrynic acid - d5 An internal standard for the quantification of ethacrynic acid
  36. GC38678 Ethyl Caffeate Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
  37. GC38548 Eurycomalactone Eurycomalactone 是一种天然产物,为有效的 NF-κB 抑制剂,IC50 值为 0.5 μM。Eurycomalactone 可抑制蛋白合成,降低 cyclin D1 蛋白水平,但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
  38. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin
  39. GC33717 Flaconitine (Acetylaconitine) A diterpene alkaloid with diverse biological activities
  40. GN10727 Forsythoside B A phenylpropanoid glycoside with diverse biological activities
  41. GC39382 FW1256 FW1256 是一种苯基类似物,也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性,并可诱导细胞凋亡 (apoptosis),并可用于癌症,炎症和心血管疾病的研究。
  42. GC64663 Galloylpaeoniflorin Galloylpaeoniflorin 是 NF-κB 抑制剂。并且 Galloylpaeoniflorin 是一种DNA裂解的抑制剂。
  43. GN10156 Ginsenoside Rb1 A triterpene saponin with diverse biological activities
  44. GN10220 Ginsenoside Rb3 A steroid glycoside with diverse biological activities
  45. GN10549 Ginsenoside Rd A natural steroid glycoside with diverse effects
  46. GN10307 Ginsenoside Re A natural steroid glycoside with diverse effects
  47. GN10544 Ginsenoside Rg1

    人参皂苷Rg1是人参的主要活性成分之一,是一种具有多种生物活性的甾体糖苷。人参皂苷Rg1可降低大脑Aβ 水平并减少 NF-κB 核转移。

  48. GN10614 Ginsenoside Rg2 A natural steroid glycoside with diverse effects
  49. GN10799 Ginsenoside Rg3 A natural steroid glycoside with diverse effects
  50. GC31706 Ginsenoside Rg5 A ginsenoside with diverse biological activities
  51. GN10019 Ginsenoside Rg6 Ginsenoside Rg6 抑制 TNF-α 诱导的 NF-κB 转录活性,在 HepG2 细胞中的 IC50 为 29.34 μM。

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