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Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for  Reactive Oxygen Species

  1. Cat.No. 产品名称 Information
  2. GC41623 β-Elemonic Acid A triterpene with anticancer activity
  3. GC41502 β-Myrcene A terpene with antioxidative properties
  4. GC67191 (±)-α-Tocopherol nicotinate (±)-α-Tocopherol nicotinate,维生素 E-烟酸酯,是一种具有口服活性的脂溶性抗氧化剂,能够防止细胞膜脂质过氧化。(±)-α-Tocopherol nicotinate 在血液中可水解为 α -生育酚和烟酸,可用于相关血管疾病的研究。
  5. GC39271 (±)-Naringenin A citrus-derived flavonoid
  6. GC40355 (±)13-HpODE Hydroperoxide mixture derived from linoleic acid
  7. GC40809 (+)-β-Citronellol A monoterpene
  8. GC63969 (+)-Schisandrin B (+)-Schisandrin B 是五味子甲素 B 的一种对映体。Schisandrin B 是从五味子果实中分离出来的有效成分,对啮鼠的肝脏和心脏有抗氧化作用。
  9. GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。此外,它还能抑制谷氨酸脱氢酶1/2 (GDH1/2, GLUD1/2)的活性。.
  10. GC45248 (-)-FINO2 A ferroptosis inducer
  11. GC38316 (-)-Limonene A monoterpene with diverse biological activities
  12. GC41700 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine A stilbene derivative with antioxidant and anticancer activities
  13. GC61668 (E)-3,4-Dimethoxycinnamic acid (E)-3,4-Dimethoxycinnamicacid是3,4-Dimethoxycinnamicacid的低活性异构体。3,4-Dimethoxycinnamicacid是从Securidacainappendiculata中提取和纯化的单体。3,4-Dimethoxycinnamicacid通过ROS介导的信号途径对L-02细胞发挥抗凋亡作用。
  14. GC39747 (E/Z)-GSK5182 (E/Z)-GSK5182 是 (E)-GSK5182 和 (Z)-GSK5182 的消旋体。GSK5182 是一种高效选择性,具有口服活性的 ERRγ 反向激动剂,其 IC50 值为 79 nM。GSK5182 还能增加肝癌细胞中 reactive oxyen species (ROS) 的产生。
  15. GC41721 (R)-α-Lipoic Acid A cyclic disulfide antioxidant
  16. GC41837 1,3,7-Trimethyluric Acid A metabolite of caffeine
  17. GC46387 1,3,7-Trimethyluric Acid-d9 An internal standard for the quantification of 1,3,7-trimethyluric acid
  18. GC35037 1,3-Dicaffeoylquinic acid An HIV-1 integrase inhibitor and free radical scavenger
  19. GC46481 1-Hydroxyphenazine A P. aeruginosa virulence factor
  20. GC18235 1-O-Hexadecyl-sn-glycerol An alkyl glyceryl ether
  21. GC40146 1-Oleoyl-2-Palmitoyl-rac-glycerol A diacylglycerol
  22. GC41866 10-methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate) A chemiluminescent acridinium ester
  23. GC41868 10-Nitrooleate A novel endogenous lipid signalling molecule
  24. GC67628 2',7'-Dichlorofluorescein 2',7'-Dichlorofluorescein是一种荧光探针,可用于测量活性氧 (ROS) (Ex=496 nm 和 Em=525 nm)。
  25. GC42079 2',7'-Dichlorofluorescein diacetate A cell-permeable fluorogenic probe to quantify ROS and NO
  26. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO
  27. GC35095 2-Phospho-L-ascorbic acid trisodium salt Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products. It is used in skin care recipes for UV protection, collagen production, as an antioxidant and for its skin lightening and brightening effects. Sodium L-ascorbyl-2-phosphate (2-Phospho-L-ascorbic acid trisodium salt, L-Ascorbic acid 2-phosphate trisodium salt, Sodium ascorbyl phosphate, SAP) is a selective antioxidant and a stimulator of hepatocyte growth factor (HGF) production.
  28. GC49005 2S-Eriodictyol A flavanone with antioxidant activity
  29. GN10006 3,4-Dihydroxybenzaldehyde A polyphenol with diverse biological activities
  30. GC33992 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
  31. GC61673 3,5-Di-tert-butylphenol 3,5-Di-tert-butylphenol是一种具有抗生物膜和抗真菌活性的挥发性有机化合物。3,5-Di-tert-butylphenol会引起活性氧(ROS)的积累。
  32. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
  33. GC14282 3-acetyl-11-keto-β-Boswellic Acid A selective 5-LO inhibitor
  34. GC49849 3-Aminosalicylic Acid A salicylic acid derivative
  35. GC62794 3-Demethylcolchicine An active metabolite of colchicine
  36. GC49364 3-Hydroxycoumarin A coumarin with diverse biological activities
  37. GC45337 3-Hydroxyterphenyllin A fungal metabolite with diverse biological activities
  38. GC31290 3-Indolepropionic acid A bacterial metabolite with antioxidant and neuroprotective activities
  39. GC42338 4-Aminobenzoic Acid hydrazide An MPO inhibitor
  40. GC42351 4-carboxy TEMPO A spin label
  41. GC42401 4-hydroperoxy Cyclophosphamide

    An activated analog of cyclophosphamide

  42. GC18858 4-hydroxy Alternariol A metabolite of alternariol
  43. GC40477 4-Thiouracil A photoreactive nucleobase analog
  44. GC49339 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate An oxidant-sensitive fluorescent probe
  45. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
  46. GC45357 5-Chlorouracil A chlorinated derivative of uracil
  47. GC49233 5-Feruloylquinic Acid A chlorogenic acid with antioxidant activity
  48. GC39760 5-Galloylquinic acid 5-Galloylquinic acid 是绿茶中活性氧 (ROS) 的主要清除剂。
  49. GC46033 5-Heneicosylresorcinol An alkylresorcinol
  50. GC61638 5-Hydroxyoxindole 5-Hydroxyoxindole是尿酸的一种结构类似物。5-Hydroxyoxindole具有自由基DPPH清除活性和脂质过氧化抑制活性。5-Hydroxyoxindole可用于氧化应激介导的疾病的研究。
  51. GC46079 5-Tricosylresorcinol An alkylresorcinol

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