HIF(缺氧诱发因素)

Hypoxia inducible factors (HIFs) are heterodimeric proteins belonging to the basic helix-loop-helix-PAS (bHLH/PAS) family of transcription factors that mediate the primary transcriptional response to stress caused by hypoxia (accessible O2 level < 2%). HIFs are characterized by containing two subunits, including O2-labile α subunit (HIFα) and constitutively expressed β subnit (HIFβ). Mammalian HIFα consists of three isoforms, including HIF1α, HIF2α and HIF3α, which play an essential role in the regulation of HIF activity by O2 availability. Under normal O2 tension, HIFα is hydroxylated at the two conserved proline residues within the O2-dependent degradation (ODD) domain by prolylhydroxylase domain proteins (PHDs) and undergoes proteosomal degradation catalyzed by a complex formed by E3 ubiquitin ligase and the von Hippel-Lindau protein (pVHL); while, under hypoxia, HIFα stabilizes with PHDs being deactivated and hence induce transcription of genes with adaptive functions.

Products for HIF

Cat.No. 产品名称 Information
GC32948 IDF-11774 IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
GC32945 THS-044 THS-044结合且稳定化HIF2αPAS-B折叠状态,调节HIF2活性。
GC32876 SYP-5 A HIF-1 inhibitor
GC32724 LW6 (HIF-1α inhibitor)
LW6 is a hypoxia-inducing factor 1(HIF) inhibitor, which effectively inhibits HIF-1α accumulation by degrading HIF-1α, but does not affect HIF-1A mRNA level during hypoxia.
GC32680 PT-2385 PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.
GC32449 Desidustat An inhibitor of HIF-PH
GC32228 Tilorone dihydrochloride An interferon-inducing antiviral agent
GC32083 Acriflavine Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。
GC31498 TP0463518 A pan HIF-PH inhibitor
GC31358 HIF-2α-IN-1 HIF-2α-IN-1是一种HIF-2α抑制剂,IC50值小于500nM。
GC31230 Dencichin (Dencichine) Dencichin是一种最初从三七中提取的非蛋白质氨基酸，可以抑制HIF-脯氨酰羟化酶2（PHD-2）的活性。
GC30263 Glucosamine (D-Glucosamine) Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
GC19251 MK-8617 A HIF-PH1, -2, and -3 inhibitor
GC18236 Echinomycin An inhibitor of HIF-1-mediated gene transcription
GC16811 Vadadustat An inhibitor of HIF-PH2 and HIF-PH3
GC15379 JNJ-42041935 A selective inhibitor of HIF-PH enzymes
GC12255 IOX4 A selective, bioavailable inhibitor of HIF-PH2
GC14282 3-acetyl-11-keto-β-Boswellic Acid A selective 5-LO inhibitor
GC16647 Daprodustat(GSK1278863) A HIF-PH1, -2, and -3 inhibitor
GC11031 PX-478 2HCl
PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平
GC12821 Oltipraz A Nrf2 and CAR activator
GC10046 Molidustat (BAY85-3934) A pan-HIF-PH inhibitor
GC16638 FG2216 An inhibitor of HIF-PH2
GC11767 Hydralazine HCl An antihypertensive agent
GC12698 BAY 87-2243 A mitochondrial complex I inhibitor and inducer of ferroptosis
GC16973 DMOG An HIF-PH inhibitor
GC15594 PX 12 An irreversible inhibitor of thioredoxin-1
GC14319 ML 228 A HIF pathway activator
GC13141 KC7F2 An inhibitor of HIF-1a protein synthesis
GC17405 Chetomin An inhibitor of HIF signaling
GC13018 IOX2(Glycine) A selective PHD2 inhibitor
GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂,抑制HIF-1α核积累以及HIF转录活性。2-Methoxyestradiol可触发p53诱导的细胞凋亡, 具有潜在的抗肿瘤活性。.
GC13139 FG-4592 (ASP1517) An inhibitor of HIF-PH enzymes
GN10518 Chitosamine hydrochloride An amino monosaccharide
GN10669 Glucosamine sulfate 氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。
GN10308 Chlorogenic acid
A phenolic natural product with antioxidant activity
GN10452 Paeoniflorin A monoterpene glycoside with diverse cellular actions