Bromodomain(溴域)
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
Products for Bromodomain
- Cat.No. 产品名称 Information
- GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs
- GC48548 iBET-BD2 A BD2 bromodomain inhibitor
- GC48408 TW9 A dual inhibitor of BRD4 and HDAC1
- GC46675 4-Phenyl-2-pyrrolidinone A precursor and synthetic intermediate
- GC50070 I-BET 151 dihydrochloride A BRD2, BRD3, and BRD4 inhibitor
- GC43889 I-CBP112 (hydrochloride) A p300 and CBP inhibitor
- GC43320 CPI-268456 A ligand of BRD4
- GC14168 UMB-32 An inhibitor of BRD4, TAF1, and TAF1L bromodomains
- GC16763 NI-57 A BRPF bromodomain inhibitor
- GC13025 GSK6853 A selective chemical probe for the bromodomain of BRPF1
- GC13014 AZD 5153 A BRD4 inhibitor
- GC10382 CPI-637 An inhibitor of CBP/EP300 bromodomains
- GC15152 PF-CBP1 An inhibitor of the CBP and p300 bromodomains
- GC16726 BI-7273 A potent BRD9 bromodomain inhibitor
- GC16817 BI-9564 A selective BRD9/7 bromodomain inhibitor
- GC12588 I-BRD9 A BRD9 bromodomain inhibitor
- GC15789 GSK2801 A probe for BAZ2A/B bromodomains
- GC10979 PFI 4 A chemical probe for BRPF1
- GC16299 BET bromodomain inhibitor BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。
- GC14655 OXF BD 02 OXF BD 02 是 BRD4(1)(BRD4 的第一个溴结构域)的选择性抑制剂,IC50 值为 382 nM。
- GC10727 Ischemin sodium salt CBP bromodomain inhibitor
- GC12440 GSK 5959 An inhibitor of the BRPF1 bromodomain
- GC15175 BAZ2-ICR A BAZ2A/B bromodomain inhibitor
- GC17482 OF-1 A bromodomain probe for BRPF proteins
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GC16611
GW841819X
BET bromodomain inhibitor
- GC13187 I-BET 151 hydrochloride A BRD2, BRD3, and BRD4 inhibitor
- GC14361 PFI 3 Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5)
- GC14699 CPI-203 A bioavailable inhibitor of BET bromodomains
- GC14063 GSK1324726A A selective inhibitor of BET family proteins
- GC13148 MS436 MS436 是一类新的溴结构域抑制剂,对 BRD4 BrD1 具有估计的 Ki=30-50 nM 的强亲和力,对 BrD2 的选择性是 10 倍。
- GC15747 I-BET151 (GSK1210151A) A BRD2, BRD3, and BRD4 inhibitor
- GC17073 I-BET-762 Inhibitor of BET proteins
- GC14199 RVX-208 A selective BET bromodomain antagonist
- GC18096 UNC669 A selective MBT inhibitor
- GC10174 SGC-CBP30 A potent inhibitor of CREBBP/EP300 bromodomains
- GC17944 I-CBP 112 A p300 and CBP inhibitor
- GC16794 UNC1215 Potent L3MBTL3 domain inhibitor
- GC17973 OTX-015 A BRD2, BRD3, and BRD4 inhibitor
- GC10524 GSK 525768A GSK 525768A 是 GSK525762A 的非活性对映异构体。 GSK 525768A 对 BET 没有任何活动。
- GC10402 Bromosporine A non-specific bromodomain inhibitor
- GC15375 PFI-1 (PF-6405761) A BET bromodomain inhibitor
- GC13822 (-)-JQ1 A selective inhibitor of BET bromodomains
- GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains