Home >> Signaling Pathways >> Chromatin/Epigenetics >> Bromodomain


Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

Products for  Bromodomain

  1. Cat.No. 产品名称 Information
  2. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs
  3. GC48548 iBET-BD2


    A BD2 bromodomain inhibitor
  4. GC48408 TW9 A dual inhibitor of BRD4 and HDAC1
  5. GC46675 4-Phenyl-2-pyrrolidinone


    A precursor and synthetic intermediate
  6. GC50070 I-BET 151 dihydrochloride

    GSK1210151A dihydrochloride

    A BRD2, BRD3, and BRD4 inhibitor
  7. GC43889 I-CBP112 (hydrochloride) A p300 and CBP inhibitor
  8. GC43320 CPI-268456 A ligand of BRD4
  9. GC14168 UMB-32 An inhibitor of BRD4, TAF1, and TAF1L bromodomains
  10. GC16763 NI-57 A BRPF bromodomain inhibitor
  11. GC13025 GSK6853 A selective chemical probe for the bromodomain of BRPF1
  12. GC13014 AZD 5153 A BRD4 inhibitor
  13. GC10382 CPI-637 An inhibitor of CBP/EP300 bromodomains
  14. GC15152 PF-CBP1 An inhibitor of the CBP and p300 bromodomains
  15. GC16726 BI-7273 A potent BRD9 bromodomain inhibitor
  16. GC16817 BI-9564 A selective BRD9/7 bromodomain inhibitor
  17. GC12588 I-BRD9 A BRD9 bromodomain inhibitor
  18. GC15789 GSK2801 A probe for BAZ2A/B bromodomains
  19. GC10979 PFI 4 A chemical probe for BRPF1
  20. GC16299 BET bromodomain inhibitor

    BET抑制剂,CPI-0610; CPI0610; CPI 0610

    BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。
  21. GC14655 OXF BD 02 OXF BD 02 是 BRD4(1)(BRD4 的第一个溴结构域)的选择性抑制剂,IC50 值为 382 nM。
  22. GC10727 Ischemin sodium salt CBP bromodomain inhibitor
  23. GC12440 GSK 5959 An inhibitor of the BRPF1 bromodomain
  24. GC15175 BAZ2-ICR A BAZ2A/B bromodomain inhibitor
  25. GC17482 OF-1 A bromodomain probe for BRPF proteins
  26. GC16611 GW841819X

    BET bromodomain inhibitor

  27. GC13187 I-BET 151 hydrochloride A BRD2, BRD3, and BRD4 inhibitor
  28. GC14361 PFI 3


    Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5)
  29. GC14699 CPI-203 A bioavailable inhibitor of BET bromodomains
  30. GC14063 GSK1324726A


    A selective inhibitor of BET family proteins
  31. GC13148 MS436 MS436 是一类新的溴结构域抑制剂,对 BRD4 BrD1 具有估计的 Ki=30-50 nM 的强亲和力,对 BrD2 的选择性是 10 倍。
  32. GC15747 I-BET151 (GSK1210151A)


    A BRD2, BRD3, and BRD4 inhibitor
  33. GC17073 I-BET-762

    (4S)-6-(4-氯苯基)-N-乙基-8-甲氧基-1-甲基-4H-[1,2,4]三唑并[4,3-A][1,4]苯并二氮杂卓-4-乙酰胺,I-BET762; GSK525762; GSK525762A

    Inhibitor of BET proteins
  34. GC14199 RVX-208

    阿帕他隆; RVX-208; RVX000222

    A selective BET bromodomain antagonist
  35. GC18096 UNC669 A selective MBT inhibitor
  36. GC10174 SGC-CBP30


    A potent inhibitor of CREBBP/EP300 bromodomains
  37. GC17944 I-CBP 112 A p300 and CBP inhibitor
  38. GC16794 UNC1215

    UNC 1215;UNC-1215

    Potent L3MBTL3 domain inhibitor
  39. GC17973 OTX-015

    OTX 015;OTX015

    A BRD2, BRD3, and BRD4 inhibitor
  40. GC10524 GSK 525768A


    GSK 525768A 是 GSK525762A 的非活性对映异构体。 GSK 525768A 对 BET 没有任何活动。
  41. GC10402 Bromosporine A non-specific bromodomain inhibitor
  42. GC15375 PFI-1 (PF-6405761)


    A BET bromodomain inhibitor
  43. GC13822 (-)-JQ1


    A selective inhibitor of BET bromodomains
  44. GC16531 Bromodomain Inhibitor, (+)-JQ1


    A selective inhibitor of BET bromodomains

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