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4-Phenyl-2-pyrrolidinone Sale

(Synonyms: 4-苯基-2-吡咯烷酮) 目录号 : GC46675

A precursor and synthetic intermediate

4-Phenyl-2-pyrrolidinone Chemical Structure

Cas No.:1198-97-6

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500 mg
¥2,209.00
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1 g
¥4,196.00
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产品描述

4-Phenyl-2-pyrrolidinone is a precursor and synthetic intermediate.1,2 It has been used as a precursor in the synthesis of compounds with anticonvulsant and nootropic activities and is an intermediate in the synthesis of bromodomain-containing protein 4 (BRD4) bromodomain 1 inhibitors.

1.Zhmurenko, L.A., Litvinova, S.A., Mokrov, G.V., et al.Synthesis of 4-phenylpyrrolidone derivatives with anticonvulsant and nootropic activityPharm. Chem. J.53(5)429-435(2019) 2.Hilton-Proctor, J.P., Ilyichova, O., Zheng, Z., et al.Substituted 1-methyl-4-phenylpyrrolidin-2-ones — Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitorsEur. J. Med. Chem.191112120(2020)

Chemical Properties

Cas No. 1198-97-6 SDF
别名 4-苯基-2-吡咯烷酮
Canonical SMILES O=C1CC(C2=CC=CC=C2)CN1
分子式 C10H11NO 分子量 161.2
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml 储存条件 Store at -20°C
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1 mM 6.2035 mL 31.0174 mL 62.0347 mL
5 mM 1.2407 mL 6.2035 mL 12.4069 mL
10 mM 0.6203 mL 3.1017 mL 6.2035 mL
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Research Update

Challenges in GC-MS analysis: Case studies on phenibut and ethylphenidate

Forensic Sci Int 2017 Aug;277:166-178.PMID:28651175DOI:10.1016/j.forsciint.2017.06.002

The challenges associated with drug analysis using GC-MS such as thermal degradation, cyclisation or unwanted side reactions causing potential erroneous identification have become evident in view of the high surge in new drugs available in the market. Two case studies illustrated how alternative methods or modifications to existing techniques can help to circumvent the limitations. In the first case study, phenibut which is a GABA analogue, cyclises to 4-Phenyl-2-pyrrolidinone under thermal conditions. The identification of phenibut was achieved through derivatisation and identification of its TMS derivative. The second case study, thermal degradation was minimised on drugs of interest methylphenidate and ethylphenidate by reducing the injector port temperature to 200°C and maintaining the GC oven temperature at below 190°C in order to prevent thermal degradation of the drugs of interest.