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CUDA Sale

目录号 : GC12043

A potent inhibitor of soluble epoxide hydrolase

CUDA Chemical Structure

Cas No.:479413-68-8

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5mg
¥510.00
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10mg
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50mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

IC50: 11.1 and 112 nM for the mouse and human soluble epoxide hydrolase, respectively

CUDA is a soluble epoxide hydrolase (sEH) inhibitor.

Epoxyeicosatrienoic acid metabolites of arachidonic acid, such as 11(12)-EET and 14(15)-EET, have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) can catalyze the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids thereby diminishing their activity.

In vitro: In a previous study, in order to test if the CUDA’s mechanism of action is retained upon structural modification, the dissociation constants of CUDA was evaluated for mouse sEH. Results showed that for CUDA, competitive a tight-binding inhibition kinetic was obtained with r2 > 0.99. Moreover, the KI value of 3.8 nM was obtained for CUDA. In addition, it was found that CUDA was an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] C.  Morisseau, M. H. Goodrow, J. W. Newman, et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochemical Pharmacology 63, 1599-1608 (2002).

Chemical Properties

Cas No. 479413-68-8 SDF
化学名 12-[[(cyclohexylamino)carbonyl]amino]-dodecanoic acid
Canonical SMILES O=C(NCCCCCCCCCCCC(O)=O)NC1CCCCC1
分子式 C19H36N2O3 分子量 340.5
溶解度 ≤1mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.9369 mL 14.6843 mL 29.3686 mL
5 mM 0.5874 mL 2.9369 mL 5.8737 mL
10 mM 0.2937 mL 1.4684 mL 2.9369 mL
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