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Guvacoline (hydrobromide) Sale

(Synonyms: 氢溴酸胍喹啉,Norarecoline) 目录号 : GC15845

A muscarinic receptor agonist

Guvacoline (hydrobromide) Chemical Structure

Cas No.:17210-51-4

规格 价格 库存 购买数量
1mg
¥619.00
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5mg
¥2,253.00
现货
10mg
¥4,219.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Target: atrial and ileal muscarinic receptors

IC50: 2.1 mM for growth inhibition of human buccal epithelial cells

Guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. Guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.

In Vitro: In human buccal epithelial cells, Guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the IC50 value of 2.1 mM. Besides, Guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mM Guvacoline caused 25% decrease) and increase the number of single strand breaks [1].

In Vivo: No data available recently.

Clinical trial: No data available recently.

Reference:
[1] K.  Sundqvist, Y. Liu, J. Nair, et al. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Research 49(19), 5294-5298 (1989).

Chemical Properties

Cas No. 17210-51-4 SDF
别名 氢溴酸胍喹啉,Norarecoline
化学名 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide
Canonical SMILES O=C(OC)C1=CCCNC1.Br
分子式 C7H11NO2 • HBr 分子量 222.1
溶解度 ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 4.5025 mL 22.5124 mL 45.0248 mL
5 mM 0.9005 mL 4.5025 mL 9.005 mL
10 mM 0.4502 mL 2.2512 mL 4.5025 mL
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