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Histone Methyltransferase(组蛋白甲基转移酶)

Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).

  1. Cat.No. 产品名称 Information
  2. GC25159 BMF-219 BMF-219 is a novel, potent, irreversible menin inhibitor, can be used in the treatment of leukemia.
  3. GC67934 EEDi-5285
  4. GC67863 DDO-2093 dihydrochloride
  5. GC67758 MM-401 TFA
  6. GC67676 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
  7. GC65980 EZH2-IN-13
  8. GC65962 Dot1L-IN-5
  9. GC65918 AS-85
  10. GC65509 PROTAC EZH2 Degrader-1
  11. GC65254 MC4355
  12. GC65186 DC-S239
  13. GC65045 (S)-MRTX-1719
  14. GC65037 MM-589 TFA
  15. GC65027 PRMT5-IN-20
  16. GC64941 PR5-LL-CM01
  17. GC64900 EZM0414 EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.
  18. GC64894 SETDB1-TTD-IN-1 TFA
  19. GC64893 SETDB1-TTD-IN-1
  20. GC64772 NV03
  21. GC64343 EPZ-719
  22. GC64295 MS67
  23. GC64124 AZ506
  24. GC64083 UNC6934 UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.
  25. GC63731 BRD0639 An inhibitor of the protein-peptide interaction between PRMT5 and PBM
  26. GC63662 DCLX069
  27. GC63558 MRTX-1719 MRTX1719 is a potent, selective inhibitor of the protein arginine methyltransferase 5·methylthioadenosine phosphorylase complex (PRMT5?MTA), a potentially tumor-selective target for therapeutic intervention.
  28. GC63546 FTX-6058 hydrochloride
  29. GC63545 FTX-6058
  30. GC63080 MRTX9768 hydrochloride
  31. GC63056 MAK683-CH2CH2COOH
  32. GC62849 AS-99 TFA
  33. GC49398 GSK3368715 (hydrochloride) An inhibitor of type I PRMTs
  34. GC48980 EPZ004777 (formate) DOT1L 的有效抑制剂
  35. GC62717 PROTAC EED degrader-2
  36. GC62715 MRTX9768
  37. GC62615 AS-99
  38. GC62613 Dot1L-IN-4 A DOT1L inhibitor
  39. GC62558 WDR5-IN-1
  40. GC62555 SETD2-IN-1 TFA
  41. GC62390 SW2_110A
  42. GC62187 PROTAC EED degrader-1
  43. GC61468 MR837
  44. GC48967 D-Homoserine lactone An enantiomer of L-homoserine lactone
  45. GC48463 Bisubstrate Inhibitor 78 An inhibitor of NNMT
  46. GC50699 SGC 6870 Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM)
  47. GC50697 GSK 591 dihydrochloride A chemical probe for PRMT5
  48. GC47294 Entacapone-d10 An internal standard for the quantification of entacapone
  49. GC61142 NSC745885
  50. GC61058 Metoprine
  51. GC60579 Amodiaquine dihydrochloride A prodrug form of N-desethyl amodiaquine

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