Histone Methyltransferase(组蛋白甲基转移酶)
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).
- Cat.No. 产品名称 Information
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GC25159
BMF-219
BMF-219 is a novel, potent, irreversible menin inhibitor, can be used in the treatment of leukemia.
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GC67934
EEDi-5285
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GC67863
DDO-2093 dihydrochloride
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GC67758
MM-401 TFA
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GC67676
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
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GC65980
EZH2-IN-13
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GC65962
Dot1L-IN-5
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GC65918
AS-85
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GC65509
PROTAC EZH2 Degrader-1
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GC65254
MC4355
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GC65186
DC-S239
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GC65045
(S)-MRTX-1719
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GC65037
MM-589 TFA
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GC65027
PRMT5-IN-20
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GC64941
PR5-LL-CM01
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GC64900
EZM0414
EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.
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GC64894
SETDB1-TTD-IN-1 TFA
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GC64893
SETDB1-TTD-IN-1
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GC64772
NV03
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GC64343
EPZ-719
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GC64295
MS67
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GC64124
AZ506
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GC64083
UNC6934
UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.
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GC63731
BRD0639
An inhibitor of the protein-peptide interaction between PRMT5 and PBM
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GC63662
DCLX069
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GC63558
MRTX-1719
MRTX1719 is a potent, selective inhibitor of the protein arginine methyltransferase 5·methylthioadenosine phosphorylase complex (PRMT5?MTA), a potentially tumor-selective target for therapeutic intervention.
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GC63546
FTX-6058 hydrochloride
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GC63545
FTX-6058
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GC63080
MRTX9768 hydrochloride
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GC63056
MAK683-CH2CH2COOH
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GC62849
AS-99 TFA
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GC49398
GSK3368715 (hydrochloride)
An inhibitor of type I PRMTs
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GC48980
EPZ004777 (formate)
DOT1L 的有效抑制剂
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GC62717
PROTAC EED degrader-2
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GC62715
MRTX9768
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GC62615
AS-99
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GC62613
Dot1L-IN-4
A DOT1L inhibitor
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GC62558
WDR5-IN-1
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GC62555
SETD2-IN-1 TFA
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GC62390
SW2_110A
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GC62187
PROTAC EED degrader-1
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GC61468
MR837
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GC48967
D-Homoserine lactone
An enantiomer of L-homoserine lactone
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GC48463
Bisubstrate Inhibitor 78
An inhibitor of NNMT
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GC50699
SGC 6870
Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM)
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GC50697
GSK 591 dihydrochloride
A chemical probe for PRMT5
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GC47294
Entacapone-d10
An internal standard for the quantification of entacapone
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GC61142
NSC745885
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GC61058
Metoprine
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GC60579
Amodiaquine dihydrochloride
A prodrug form of N-desethyl amodiaquine