Histone Methyltransferase(组蛋白甲基转移酶)
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).
Products for Histone Methyltransferase
- Cat.No. 产品名称 Information
- GC12005 C7280948 A PRMT1 inhibitor
- GC11414 GSK503 A potent, selective EZH2 inhibitor
- GC15302 EPZ015666 A bioavailable PRMT5 inhibitor
- GC14763 WDR5 0103 An inhibitor of WDR5 peptide binding
- GC15652 UNC 2400 UNC 2400 与 UNC1999 非常相似,作为细胞研究的阴性对照,其效力比 UNC1999 低 1,000 倍以上。
- GC16015 A 366 A potent inhibitor of G9a
- GC10259 BRD4770 An inhibitor of EHMT2/G9a
- GC10021 CPI-360 A selective EZH2 inhibitor
- GC17956 PFI-2 PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride 是一种有效的选择性 SET 结构域,含有赖氨酸甲基转移酶 7 (SETD7) 抑制剂。
- GC16741 UNC0379 A selective SET8 inhibitor
- GC14249 UNC 0642 A G9a histone methyltransferase inhibitor
- GC16130 C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor
- GC17672 TC-E 5003 A PRMT1 inhibitor
- GC11340 (R)-PFI 2 hydrochloride A SET7/9 inhibitor
- GC16599 CPI-169 A selective EZH2 inhibitor
- GC15259 EPZ004777 HCl EPZ004777 HCl 是一种有效的选择性 DOT1L 抑制剂,IC50 为 0.4 nM。
- GC14756 EI1 A selective inhibitor of EZH2
- GC13103 AZ505 ditrifluoroacetate An inhibitor of SMYD2
- GC13744 AZ505 An inhibitor of SMYD2
- GC12548 UNC 0631 An inhibitor of G9a/GLP methyltransferases
- GC14364 SGI-1027 A DNA methyltransferase inhibitor
- GC11375 UNC1999 A selective, cell-permeable EZH2 inhibitor
- GC14652 MM-102 An inhibitor of WDR5/MLL interactions
- GC18096 UNC669 A selective MBT inhibitor
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GC14062
EPZ-6438
A selective EZH2 inhibitor
- GC15688 UNC 0224 A potent inhibitor of G9a histone methyltransferase
- GC16256 BVT 948 An inhibitor of protein tyrosine phosphatases
- GC16518 UNC 0646 An inhibitor of G9a/GLP methyltransferases
- GC14936 Chaetocin Inhibitor of lys9-specific HMTs
- GC16794 UNC1215 Potent L3MBTL3 domain inhibitor
- GC17534 GSK343 A selective, cell-permeable EZH2 inhibitor
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GC15783
GSK126
A selective EZH2 inhibitor
- GC13383 EPZ004777 A potent inhibitor of DOT1L
- GC11491 SGC 0946 A potent inhibitor of DOT1L
- GC13878 EPZ005687 A potent, selective inhibitor of EZH2
- GC17334 Entacapone A reversible COMT inhibitor
- GC12932 EPZ5676 A highly potent DOT1L inhibitor
- GC17907 3-Deazaneplanocin A (DZNep) hydrochloride An inhibitor of the lysine methyltransferase EZH2
- GC15610 UNC0638 A G9a and GLP histone methyltransferase inhibitor
- GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase
- GC17275 AMI-1 A cell permeable inhibitor of PRMTs
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GC13145
3-Deazaneplanocin,DZNep
An inhibitor of lysine methyltransferase EZH2
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GP10020
Histone-H2A-(107-122)-Ac-OH
Histone-H2A peptide