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Home >> Signaling Pathways >> Chromatin/Epigenetics >> HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

  1. Cat.No. 产品名称 Information
  2. GC25552 KT-531 KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms.
  3. GC25139 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
  4. GC67984 Alteminostat
  5. GC67674 CRA-026440 hydrochloride
  6. GC66055 5-Phenylpentan-2-one
  7. GC66052 HDAC-IN-40
  8. GC65965 MPT0E028
  9. GC65460 HDACs/mTOR Inhibitor 1
  10. GC65426 CM-675
  11. GC65330 AES-135
  12. GC65206 FT895
  13. GC64968 SW-100
  14. GC64959 JAK/HDAC-IN-1
  15. GC64942 CHDI-390576
  16. GC64761 Butyric acid-13C1
  17. GC64729 MPT0B390
  18. GC64684 SB-429201
  19. GC64378 Valproic acid-d6
  20. GC64191 Elevenostat
  21. GC49693 HDAC5 (human, recombinant) Active, pure human recombinant enzyme
  22. GC63730 QTX125 TFA
  23. GC63703 Ivaltinostat formic
  24. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
  25. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs
  26. GC48986 9-hydroxy Stearic Acid A hydroxy fatty acid
  27. GC62461 FNDR-20123
  28. GC62430 KA2507 KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.
  29. GC62411 QTX125
  30. GC62374 KA2507 monohydrochloride KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.
  31. GC62308 MPT0G211
  32. GC61947 Triciferol
  33. GC48775 AES-350 An inhibitor of class I and class IIb HDACs
  34. GC48460 NR-160 An inhibitor of HDAC6
  35. GC48408 TW9 A dual inhibitor of BRD4 and HDAC1
  36. GC48084 Sodium 4-Phenylbutyrate-d11 An internal standard for the quantification of sodium 4-phenylbutyrate
  37. GC61029 Marein A glucoside chalcone with diverse biological activities
  38. GC60310 Psammaplin A
  39. GC39679 CG347B
  40. GC50322 BRD 9757 Potent and selective HDAC6 inhibitor
  41. GC39214 1-Naphthohydroxamic acid
  42. GC46226 SS-208 An HDAC6 inhibitor
  43. GC38742 BRD-6929 An HDAC1 and HDAC2 inhibitor
  44. GC45906 MC1742 An inhibitor of class I and class IIb HDACs
  45. GC45717 Chlamydocin An HDAC inhibitor
  46. GC38412 Crotonoside A guanosine analog with diverse biological activities
  47. GA20605 Ac-Lys-AMC Ac-Lys-AMC（己酰胺），也称为 MAL，是组蛋白去乙酰化酶 HDAC 的荧光底物。
  48. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的底物。
  49. GC37845 Tucidinostat An HDAC inhibitor
  50. GC37753 Tefinostat
  51. GC37643 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

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