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Home >> Signaling Pathways >> Chromatin/Epigenetics >> PARP

PARP(多聚ADP核糖聚合酶)

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

  1. Cat.No. 产品名称 Information
  2. GC67962 Simmiparib
  3. GC67906 OM-153
  4. GC65927 PARP-2-IN-1
  5. GC65907 KSQ-4279
  6. GC65899 AZ3391
  7. GC65202 Nesuparib
  8. GC65147 PROTAC PARP1 degrader
  9. GC64579 PARP-1-IN-2
  10. GC64578 PARP1-IN-8
  11. GC64209 E7016
  12. GC62805 4’-Methoxychalcone 4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
  13. GC62781 2-Methylquinazolin-4-ol
  14. GC62473 RBN012759 A PARP14 inhibitor
  15. GC62310 AZD5305 AZD5305 is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM).
  16. GC62275 PARP1-IN-5 dihydrochloride
  17. GC62252 Mefuparib hydrochloride
  18. GC62154 N-Descyclopropanecarbaldehyde Olaparib
  19. GC62129 Venadaparib Venadaparib (IDX-1197), a potent PARP1/2 inhibitor with IC50 values of 1.4 nM and 1.0 nM respectively, prevents the repair of DNA single-strand breaks (SSB) and promotes the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells.
  20. GC62121 Fluzoparib Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.
  21. GC62105 Senaparib
  22. GC47693 m-Methoxybenzamide A PARP inhibitor
  23. GC47056 CAY10753 A TNKS2 inhibitor
  24. GC47055 CAY10749 A dual inhibitor of PARP and PI3K
  25. GC46900 AZ9482 A PARP inhibitor
  26. GC50506 Fluorescein-NAD+ 荧光素-NAD+ 是放射性标记的 NAD 的替代品，也是 ADP 核糖基化的底物。
  27. GC39302 PARP14 inhibitor H10
  28. GC45808 OUL35 An inhibitor of PARP10
  29. GC45772 6(5H)-Phenanthridinone An inhibitor of PARP1 and 2
  30. GC37735 Tankyrase-IN-2 A TNKS1/2 inhibitor
  31. GC37728 Talazoparib tosylate
  32. GC36855 Paris saponin VII Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
  33. GC36751 NMS-P515
  34. GC35550 BRCA1-IN-2
  35. GC35547 BR102375
  36. GC35150 5,7,4'-Trimethoxyflavone 4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
  37. GC40468 1,5-Isoquinolinediol An inhibitor of poly(ADP-ribose) polymerases
  38. GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。
  39. GC10456 Fucosterol A natural phytosterol with diverse biological activities
  40. GC19505 RK-287107 A TNKS1/2 inhibitor
  41. GC34195 K-756
  42. GC34120 Niraparib R-enantiomer (MK 4827 (R-enantiomer))
  43. GC34071 Pamiparib (BGB-290) A PARP1 and PARP2 inhibitor
  44. GC33358 WD2000-012547
  45. GC33223 BRCA1-IN-1
  46. GC32793 Rucaparib Camsylate A PARP1 inhibitor
  47. GC19264 NMS-P118 A potent and selective PARP1 inhibitor
  48. GC18172 E7449 An inhibitor of PARP1, PARP2, and TNKS1/2
  49. GC16725 AZ6102 A TNKS1/2 inhibitor
  50. GC14380 BGP-15 A PARP inhibitor and insulin sensitizer
  51. GC17555 NVP-TNKS656 A TNKS2 inhibitor

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