PARP(多聚ADP核糖聚合酶)
Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.
- Cat.No. 产品名称 Information
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GC67962
Simmiparib
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GC67906
OM-153
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GC65927
PARP-2-IN-1
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GC65907
KSQ-4279
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GC65899
AZ3391
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GC65202
Nesuparib
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GC65147
PROTAC PARP1 degrader
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GC64579
PARP-1-IN-2
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GC64578
PARP1-IN-8
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GC64209
E7016
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GC62805
4’-Methoxychalcone
4'-Methoxychalcone, found in citrus, is chalcone derivative that has shown diverse pharmacological properties, including anti-tumor and anti-inflammatory activities. 4'-Methoxychalcone significantly enhanced adipocyte differentiation, in part, by its potent effects on PPARγ activation and by its reverse effect on TNF-α.
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GC62781
2-Methylquinazolin-4-ol
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GC62473
RBN012759
A PARP14 inhibitor
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GC62310
AZD5305
AZD5305 is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM).
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GC62275
PARP1-IN-5 dihydrochloride
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GC62252
Mefuparib hydrochloride
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GC62154
N-Descyclopropanecarbaldehyde Olaparib
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GC62129
Venadaparib
Venadaparib (IDX-1197), a potent PARP1/2 inhibitor with IC50 values of 1.4 nM and 1.0 nM respectively, prevents the repair of DNA single-strand breaks (SSB) and promotes the conversion of SSB to double-stranded breaks (DSB), which ultimately leads to synthetic lethality in cancer cells.
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GC62121
Fluzoparib
Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.
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GC62105
Senaparib
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GC47693
m-Methoxybenzamide
A PARP inhibitor
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GC47056
CAY10753
A TNKS2 inhibitor
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GC47055
CAY10749
A dual inhibitor of PARP and PI3K
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GC46900
AZ9482
A PARP inhibitor
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GC50506
Fluorescein-NAD+
荧光素-NAD+ 是放射性标记的 NAD 的替代品,也是 ADP 核糖基化的底物。
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GC39302
PARP14 inhibitor H10
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GC45808
OUL35
An inhibitor of PARP10
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GC45772
6(5H)-Phenanthridinone
An inhibitor of PARP1 and 2
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GC37735
Tankyrase-IN-2
A TNKS1/2 inhibitor
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GC37728
Talazoparib tosylate
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GC36855
Paris saponin VII
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
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GC36751
NMS-P515
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GC35550
BRCA1-IN-2
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GC35547
BR102375
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GC35150
5,7,4'-Trimethoxyflavone
4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
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GC40468
1,5-Isoquinolinediol
An inhibitor of poly(ADP-ribose) polymerases
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GC19542
GeA-69
GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂,靶向大结构域 2 (MD2),Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。
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GC10456
Fucosterol
A natural phytosterol with diverse biological activities
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GC19505
RK-287107
A TNKS1/2 inhibitor
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GC34195
K-756
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GC34120
Niraparib R-enantiomer (MK 4827 (R-enantiomer))
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GC34071
Pamiparib (BGB-290)
A PARP1 and PARP2 inhibitor
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GC33358
WD2000-012547
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GC33223
BRCA1-IN-1
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GC32793
Rucaparib Camsylate
A PARP1 inhibitor
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GC19264
NMS-P118
A potent and selective PARP1 inhibitor
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GC18172
E7449
An inhibitor of PARP1, PARP2, and TNKS1/2
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GC16725
AZ6102
A TNKS1/2 inhibitor
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GC14380
BGP-15
A PARP inhibitor and insulin sensitizer
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GC17555
NVP-TNKS656
A TNKS2 inhibitor