PARP(多聚ADP核糖聚合酶)
Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.
Products for PARP
- Cat.No. 产品名称 Information
- GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂,靶向大结构域 2 (MD2),Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。
- GC10456 Fucosterol A natural phytosterol with diverse biological activities
- GC19505 RK-287107 A TNKS1/2 inhibitor
- GC34195 K-756 K-756是一种直接的选择性tankyrase(TNKS)抑制剂,抑制TNKS1和TNKS2的ADP-核糖基化活性,IC50分别为31和36nM。
- GC34120 Niraparib R-enantiomer (MK 4827 (R-enantiomer)) Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂,IC50 为 2.4 nM。
- GC34071 Pamiparib (BGB-290) A PARP1 and PARP2 inhibitor
- GC33358 WD2000-012547 WD2000-012547是一种选择性的PARP-1抑制剂,pKi为8.221。
- GC33223 BRCA1-IN-1 BRCA1-IN-1是一种新型的小分子BRCA1抑制剂,IC50和Ki分别为0.53μM和0.71μM。
- GC32793 Rucaparib Camsylate A PARP1 inhibitor
- GC19264 NMS-P118 A potent and selective PARP1 inhibitor
- GC18172 E7449 An inhibitor of PARP1, PARP2, and TNKS1/2
- GC16725 AZ6102 A TNKS1/2 inhibitor
- GC14380 BGP-15 A PARP inhibitor and insulin sensitizer
- GC17555 NVP-TNKS656 A TNKS2 inhibitor
- GC16914 MN 64 A TNKS inhibitor
- GC13541 G007-LK A TNKS1/2 inhibitor
- GC13249 Rucaparib (free base) A PARP1 inhibitor
- GC17052 MK-4827 Racemate selective inhibitor of PARP1/PARP2
- GC11537 MK-4827 tosylate An orally bioavailable PARP1/2 inhibitor
- GC12756 MK-4827 hydrochloride MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂,IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复,激活细胞凋亡并显示出抗肿瘤活性。
- GC13419 ME0328 A selective PARP3 inhibitor
- GC11548 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
- GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor
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GC12781
XAV-939
A TNKS inhibitor
- GC11674 WIKI4 A potent TNKS1/2 inhibitor
- GC17775 NU 1025 An inhibitor of PARP
- GC12869 JW 55 A TNKS1/2 inhibitor
- GC12991 EB 47 A PARP1 and TNKS2 inhibitor
- GC12680 DR 2313 A PARP inhibitor
- GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor
- GC10690 BYK 204165 A selective inhibitor of PARP1
- GC16474 4-HQN A heterocyclic building block
- GC17783 Veliparib dihydrochloride An orally bioavailable inhibitor of PARP1 and PARP2
- GC10995 PJ34 An inhibitor of poly (ADP-ribose) polymerases
- GC17802 MK-4827 An orally bioavailable PARP1/2 inhibitor
- GC10920 BMN-673 8R,9S BMN-673 8R,9S ((8R,9S)-BMN-673) 是 Talazoparib 的对映异构体。 BMN-673 8R,9S 是一种 PARP1 抑制剂,IC50 为 144 nM。
- GC17965 AZD2461 A PARP inhibitor
- GC14509 UPF 1069 A selective PARP2 inhibitors
- GC12496 INO-1001 A PARP inhibitor
- GC12390 A-966492 A PARP1 and PARP2 inhibitor
- GC10145 PJ34 hydrochloride An inhibitor of poly (ADP-ribose) polymerases
- GC16318 AG-14361 A PARP1 inhibitor
- GC15353 Iniparib (BSI-201) A PARP1 inhibitor
- GC15955 Rucaparib (AG–014699,PF–01367338) phosphate A PARP1 inhibitor
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GC17580
Olaparib (AZD2281, Ku-0059436)
A PARP inhibitor
- GC15932 BMN 673 A PARP inhibitor
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GC12422
ABT-888 (Veliparib)
ABT-888 (Veliparib) (ABT-888) 是一种有效的 PARP 抑制剂,抑制 PARP1 和 PARP2,Kis 分别为 5.2 和 2.9 nM。
- GN10629 5,7-dihydroxychromone A flavone decomposition product with diverse biological activities
- GN10114 Oroxin A A flavonoid glycoside
- GN10040 Dehydrocorydaline An alkaloid with diverse biological activities