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Aurora Kinase(极光激酶)

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

  1. Cat.No. 产品名称 Information
  2. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
  3. GC68147 dAURK-4 hydrochloride
  4. GC67899 Aurora kinase inhibitor-8
  5. GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
  6. GC48971 AZD 1152 (hydrochloride) A prodrug for a potent Aurora B inhibitor
  7. GC62482 TAS-119
  8. GC62433 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.
  9. GC62189 CD532 hydrochloride An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
  10. GC62145 Chiauranib Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
  11. GC50050 Hesperadin hydrochloride A multi-kinase inhibitor
  12. GC38519 Ilorasertib hydrochloride A multi-kinase inhibitor
  13. GC37606 SCH-1473759 hydrochloride
  14. GC35651 Cenisertib
  15. GC35216 AAPK-25
  16. GC42933 Binucleine 2 An inhibitor of Drosophila Aurora B kinase
  17. GC40667 Aurora Kinase Inhibitor II Blocks Aurora A kinase activity
  18. GC34692 NU6140 A Cdk2 inhibitor
  19. GC34159 Ilorasertib (ABT-348) A multi-kinase inhibitor
  20. GC33379 Aurora B inhibitor 1
  21. GC33057 LY3295668 (AK-01) LY3295668 (AK-01) is a potent, orally active and specific inhibitor of Aurora A kinase with Ki of 0.8 nM and 1038 nM for AURKA and AURKB, respectively.
  22. GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
  23. GC15711 Aurora Kinase Inhibitor III A potent inhibitor of Aurora A kinase
  24. GC13668 Phthalazinone pyrazole Potent, selective inhibitor of Aurora kinase A
  25. GC17828 BI-847325 A selective dual MEK/Aurora kinase inhibitor
  26. GC10442 MK-8745 An Aurora A kinase inhibitor
  27. GC17455 TAK-632 A selective pan-Raf inhibitor
  28. GC16378 TC-A 2317 hydrochloride TC-A 2317 hydrochloride 是一种具有口服活性的 Aurora A 激酶抑制剂 (Ki=1.2 nM)。 TC-A 2317 hydrochloride 对 Aurora B 激酶 (Ki=101 nM) 和其他 60 种激酶具有出色的选择性、良好的细胞渗透性和良好的 PK 曲线。抗肿瘤活性。
  29. GC17284 Anacardic acid A histone acetyltransferase inhibitor
  30. GC13102 XL228 A tyrosine kinase inhibitor
  31. GC16614 SCH-1473759 SCH-1473759 是一种极光抑制剂,对极光 A 和 B 的 IC50 分别为 4 和 13 nM。
  32. GC14651 Reversine A purine derivative
  33. GC14709 AZD1152 AZD1152 (AZD1152) 是 AZD1152-hQPA 的前药,是一种高选择性的 Aurora B 抑制剂,在无细胞试验中 IC50 为 0.37 nM。 AZD1152 (AZD1152) 在癌细胞中诱导生长停滞和凋亡。
  34. GC18074 PF-03814735 An inhibitor of Aurora A and B kinases
  35. GC10008 GSK1070916 A potent inhibitor of Aurora B and C kinases
  36. GC13332 Aurora A Inhibitor I A potent and selective inhibitor of Aurora A kinase
  37. GC15106 CYC116 A potent Aurora kinase inhibitor
  38. GC11085 TAK-901 A non-selective inhibitor of Aurora kinases
  39. GC14592 KW 2449 A multi-kinase inhibitor
  40. GC10479 PHA-680632 An Aurora kinase inhibitor
  41. GC13837 SNS-314 Mesylate A pan-Aurora kinase inhibitor
  42. GC17162 MK-5108 (VX-689) A potent inhibitor of Aurora kinases
  43. GC13198 AMG-900 A selective pan-Aurora kinase inhibitor
  44. GC17196 Hesperadin A multi-kinase inhibitor
  45. GC10638 AT9283 A broad spectrum kinase inhibitor
  46. GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor
  47. GC12612 JNJ-7706621 A dual inhibitor of CDKs and Aurora kinases
  48. GC12208 MLN8054 An inhibitor of Aurora A kinase
  49. GC14566 CCT137690 An inhibitor of Aurora kinases and FLT3
  50. GC11310 CCT129202 An Aurora kinase inhibitor
  51. GC16519 ENMD-2076 A multi-kinase inhibitor

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