Aurora Kinase(极光激酶)
Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.
Products for Aurora Kinase
- Cat.No. 产品名称 Information
- GC11310 CCT129202 An Aurora kinase inhibitor
- GC16519 ENMD-2076 A multi-kinase inhibitor
- GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂,对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。
- GC14409 ZM 447439 Selective inhibitor of Aurora B kinase
- GC14955 Barasertib (AZD1152-HQPA) A selective Aurora kinase B inhibitor
- GC11549 VX-680 (MK-0457,Tozasertib) An Aurora kinase inhibitor that regulates mitosis
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GC12690
MLN8237 (Alisertib)
An Aurora A kinase inhibitor