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Histone Acetyltransferases(组蛋白乙酰转移酶)

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

  1. Cat.No. 产品名称 Information
  2. GC66049 NSC 694621
  3. GC64137 Acetaminophen-d3
  4. GC63627 DCH36_06
  5. GC63405 PU139
  6. GC62669 CPI-1612
  7. GC62248 NiCur NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
  8. GC62247 PF-9363 PF-9363 (CTx-648) is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.
  9. GC62104 WM-3835 WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
  10. GC61841 Naphthol AS-E
  11. GC50721 iP300w Potent p300/CBP inhibitor
  12. GC39365 CPTH2 A HAT inhibitor
  13. GC38469 CBP/p300-IN-3
  14. GC36975 Procyanidin B3 A polyphenol flavonoid dimer with diverse biological activities
  15. GC36887 PF-CBP1 hydrochloride An inhibitor of the CBP and p300 bromodomains
  16. GC45094 TTK21 An activator of CBP/p300 histone acetyltransferase activity
  17. GC43192 CAY10685 A “clickable” analog of CPTH2
  18. GC41984 1-Alaninechlamydocin An HDAC inhibitor
  19. GC41638 TSI-01 A LPCAT2 inhibitor
  20. GC40767 CAY10669 An inhibitor of PCAF
  21. GC40226 Curcumin-d6 An internal standard for the quantification of curcumin
  22. GC34078 I-CBP112 A p300 and CBP inhibitor
  23. GC33422 HAT-IN-1
  24. GC33371 MOZ-IN-2 An inhibitor of KAT6A/MOZ
  25. GC33212 GNE-207
  26. GC33028 CF53
  27. GC32960 GNE-049
  28. GC32880 TPOP146
  29. GC32747 GNE-272
  30. GC32677 A-485 A p300/CBP inhibitor
  31. GC32081 GNE-781 GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.
  32. GC31731 GSK 4027 A PCAF/GCN5 bromodomain inhibitor
  33. GC31245 EML 425 An inhibitor of p300 and CBP
  34. GC31099 YF-2 A HAT activator
  35. GC30714 GSK4028
  36. GC18154 WM-1119 An inhibitor of KAT6A
  37. GC18153 WM-8014 An inhibitor of KAT6A and KAT6B
  38. GC14524 CTPB A selective activator of p300 HAT
  39. GC12009 HAT Inhibitor II An inhibitor of HAT p300
  40. GC10226 Butyrolactone 3 A HAT inhibitor
  41. GC14428 CPTH2 (hydrochloride) A HAT inhibitor
  42. GC14103 NSC228155 An EGFR activator and inhibitor of KID-KIX interactions
  43. GC10382 CPI-637 An inhibitor of CBP/EP300 bromodomains
  44. GC15049 MCB-613 A small molecule stimulator of SRCs
  45. GC13474 Garcinol A polyisoprenylated benzophenone with diverse biological activities
  46. GC15836 IWP 12 A PORCN inhibitor
  47. GC11430 Remodelin A NAT10 inhibitor that rescues laminopathies
  48. GC15731 L002 A p300 acetyltransferase inhibitor
  49. GC15104 (R)-(+)-Etomoxir sodium salt An inhibitor of CPT1
  50. GC12934 YM 750 YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
  51. GC10931 VULM 1457 VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。

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