Histone Acetyltransferases(组蛋白乙酰转移酶)
Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.
- Cat.No. 产品名称 Information
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GC66049
NSC 694621
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GC64137
Acetaminophen-d3
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GC63627
DCH36_06
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GC63405
PU139
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GC62669
CPI-1612
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GC62248
NiCur
NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
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GC62247
PF-9363
PF-9363 (CTx-648) is a potent and selective KAT6A/6B inhibitor with Ki of 0.41 nM and 1.2 nM for KAT6A and KAT6B, respectively. PF-9363 displays potent anti-tumor activity in ER+ breast cancer models.
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GC62104
WM-3835
WM-3835 is a novel and high-specific small molecule Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) inhibitor, able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
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GC61841
Naphthol AS-E
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GC50721
iP300w
Potent p300/CBP inhibitor
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GC39365
CPTH2
A HAT inhibitor
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GC38469
CBP/p300-IN-3
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GC36975
Procyanidin B3
A polyphenol flavonoid dimer with diverse biological activities
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GC36887
PF-CBP1 hydrochloride
An inhibitor of the CBP and p300 bromodomains
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GC45094
TTK21
An activator of CBP/p300 histone acetyltransferase activity
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GC43192
CAY10685
A “clickable” analog of CPTH2
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GC41984
1-Alaninechlamydocin
An HDAC inhibitor
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GC41638
TSI-01
A LPCAT2 inhibitor
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GC40767
CAY10669
An inhibitor of PCAF
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GC40226
Curcumin-d6
An internal standard for the quantification of curcumin
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GC34078
I-CBP112
A p300 and CBP inhibitor
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GC33422
HAT-IN-1
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GC33371
MOZ-IN-2
An inhibitor of KAT6A/MOZ
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GC33212
GNE-207
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GC33028
CF53
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GC32960
GNE-049
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GC32880
TPOP146
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GC32747
GNE-272
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GC32677
A-485
A p300/CBP inhibitor
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GC32081
GNE-781
GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.
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GC31731
GSK 4027
A PCAF/GCN5 bromodomain inhibitor
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GC31245
EML 425
An inhibitor of p300 and CBP
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GC31099
YF-2
A HAT activator
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GC30714
GSK4028
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GC18154
WM-1119
An inhibitor of KAT6A
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GC18153
WM-8014
An inhibitor of KAT6A and KAT6B
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GC14524
CTPB
A selective activator of p300 HAT
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GC12009
HAT Inhibitor II
An inhibitor of HAT p300
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GC10226
Butyrolactone 3
A HAT inhibitor
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GC14428
CPTH2 (hydrochloride)
A HAT inhibitor
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GC14103
NSC228155
An EGFR activator and inhibitor of KID-KIX interactions
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GC10382
CPI-637
An inhibitor of CBP/EP300 bromodomains
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GC15049
MCB-613
A small molecule stimulator of SRCs
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GC13474
Garcinol
A polyisoprenylated benzophenone with diverse biological activities
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GC15836
IWP 12
A PORCN inhibitor
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GC11430
Remodelin
A NAT10 inhibitor that rescues laminopathies
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GC15731
L002
A p300 acetyltransferase inhibitor
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GC15104
(R)-(+)-Etomoxir sodium salt
An inhibitor of CPT1
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GC12934
YM 750
YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
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GC10931
VULM 1457
VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。