Histone Acetyltransferases(组蛋白乙酰转移酶)

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

Products for Histone Acetyltransferases

Cat.No. 产品名称 Information
GC31099 YF-2 A HAT activator
GC30714 GSK4028 GSK4028是GSK4027的对映体阴性对照，GSK4027是一种PCAF/GCN5溴结构域的化学探针，而GSK4028对应的pIC50值为4.9。
GC18154 WM-1119 An inhibitor of KAT6A
GC18153 WM-8014
WM8014,WM 8014
An inhibitor of KAT6A and KAT6B
GC14524 CTPB A selective activator of p300 HAT
GC12009 HAT Inhibitor II
组蛋白乙酰转移酶抑制剂II,Histone Acetyltransferase Inhibitor II
An inhibitor of HAT p300
GC10226 Butyrolactone 3
丁内酯 3; MB-3
Butyrolactone 3是组蛋白乙酰转移酶GCN5的小分子抑制剂（IC₅₀= 100μM）。
GC14428 CPTH2 (hydrochloride) A HAT inhibitor
GC14103 NSC228155 An EGFR activator and inhibitor of KID-KIX interactions
GC10382 CPI-637 An inhibitor of CBP/EP300 bromodomains
GC15049 MCB-613
4-乙基-2,6-双(吡啶-3-基亚甲基)环己酮
A small molecule stimulator of SRCs
GC13474 Garcinol
山竹子素

Garcinol是组蛋白乙酰转移酶p300和PCAF的非特异性抑制剂，IC₅₀分别为7μM和5μM。
GC15836 IWP 12
Inhibitor of Wnt Production-12
A PORCN inhibitor
GC11430 Remodelin Remodelin 是 N-乙酰转移酶 10 (NAT10) 的小分子抑制剂。
GC15731 L002
p300/CBP Inhibitor VI, NSC 764414
A p300 acetyltransferase inhibitor
GC15104 (R)-(+)-Etomoxir sodium salt
(R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt
(R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。
GC12934 YM 750 YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
GC10931 VULM 1457 VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。
GC11539 CI 976
CI 976
An inhibitor of ACAT-1
GC12917 Acetaminophen
对乙酰氨基酚; Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

An analgesic and antipyretic compound
GC12733 C646 C646是一种有效的选择性p300/CBP组蛋白乙酰转移酶抑制剂(Ki 400 nM),已被证明具有多效性,包括神经保护、抗癌和抗上皮间质转化(anti-EMT)作用。
GC14490 Donepezil HCl
盐酸多奈哌齐; E2020

An AChE inhibitor
GC11439 MG 149
Tip60 HAT inhibitor
A HAT inhibitor
GC11972 NU 9056 NU 9056（1，2-双（异噻唑-5-基）二硫烷）是一种有效且选择性的Tip60（KAT5）组蛋白乙酰转移酶（HAT）抑制剂，IC₅₀值为2μM，具有抗肿瘤活性。
GC10174 SGC-CBP30
SGCCBP30,SGC CBP30
A potent inhibitor of CREBBP/EP300 bromodomains
GC17284 Anacardic acid
漆树酸; Hydroginkgolic acid; Ginkgolic Acid C15

A histone acetyltransferase inhibitor
GC14787 Curcumin
姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow

A yellow pigment with diverse biological activities