Histone Acetyltransferases(组蛋白乙酰转移酶)

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

Products for Histone Acetyltransferases

Cat.No. 产品名称 Information
GC11430 Remodelin A NAT10 inhibitor that rescues laminopathies
GC15731 L002 A p300 acetyltransferase inhibitor
GC15104 (R)-(+)-Etomoxir sodium salt (R)-(+)-Etomoxir sodium salt(Etomoxir) is a small molecule developed for metabolic and cardiovascular disease that exhibits nanomolar potency toward CPT-1a and CPT-1b upon enzymatic conversion to the active inhibitor etomoxiryl CoA (IC50 = 0.
GC12934 YM 750 YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
GC10931 VULM 1457 VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。
GC11539 CI 976 An inhibitor of ACAT-1
GC12917 Acetaminophen
An analgesic and antipyretic compound
GC12733 C646 C646是一种有效的选择性p300/CBP组蛋白乙酰转移酶抑制剂(Ki 400 nM),已被证明具有神经保护、抗癌和抗上皮间质转化(anti-EMT)等多种作用。.
GC14490 Donepezil HCl An AChE inhibitor
GC11439 MG 149 A HAT inhibitor
GC11972 NU 9056 NU 9056 是一种有效且选择性的 Tip60 (KAT5) 组蛋白乙酰转移酶抑制剂，浓度为 2 µM。 NU 9056 对 Tip60 的选择性比 PCAF、p300 和 GCN5 高 16 倍以上。 NU 9056 诱导前列腺癌细胞凋亡。
GC10174 SGC-CBP30 A potent inhibitor of CREBBP/EP300 bromodomains
GC17284 Anacardic acid
A histone acetyltransferase inhibitor
GC14787 Curcumin A yellow pigment with diverse biological activities