Protein Ser/Thr Phosphatases(蛋白质丝氨酸/苏氨酸磷酸酶)

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for Protein Ser/Thr Phosphatases

Cat.No. 产品名称 Information
GC15974 bpV(HOpic) (potassium salt, technical grade)
Bisperoxovanadium(HOpic)
A PTEN inhibitor
GC15969 PTP Inhibitor IV
Protein Tyrosine Phosphatase Inhibitor IV
An active-site directed inhibitor of protein tyrosine phosphatases
GC11806 β-Glycerophosphate (sodium salt hydrate)
五水β-甘油磷酸钠(二钠五水合物)

An inhibitor of alkaline phosphatase
GC16900 PRL-3 Inhibitor
BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor
PRL-3 Inhibitor是一种针对再生肝磷酸酶-3（PRL-3）的抑制剂，其半数抑制浓度（IC₅₀）为0.9μM。
GC12082 Cantharidic Acid (sodium salt) A protein phosphatase inhibitor
GC15120 PTP Inhibitor I
2-溴-4'-羟基苯乙酮,α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II
A SHP-1(ΔSH2) and PTP1B inhibitor
GC15804 PTP Inhibitor II
alpha-溴-4-甲氧基苯乙酮,α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II
A SHP-1(ΔSH2) inhibitor
GC13442 Sanguinarine chloride
氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride
A natural alkaloid with anti-inflammatory and anti-oxidant properties
GC12498 Sephin1
(E/Z)-Sephin1; (E/Z)-IFB-088
A selective inhibitor of the phosphatase regulatory subunit PPP1R15A
GC12189 LB-100 A PP2A inhibitor with anticancer activity
GC11561 NSC 95397
Cdc25 Inhibitor IV, PTP Inhibitor XXIX
An irreversible inhibitor of Cdc25 isoforms
GC11381 Tautomycetin
Tautomycetin 是一种有效的特异性 PP1 抑制剂，具有潜在的细胞凋亡诱导活性。
GC14875 NSC 663284
DA-3003-1
Inhibitor of Cdc25 isoforms
GC16290 Nafamostat hydrochloride
盐酸萘莫司他
Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。
GC17676 Nafamostat
萘莫司他
Nafamostat是一种合成的丝氨酸蛋白酶抑制剂。
GC12891 CCT007093
(2E,5E)-2,5-二(2-噻吩基亚甲基)环戊酮
An inhibitor of PPM1D
GC15718 CID 2011756 An inhibitor of protein kinase D
GC12020 TCS 401 A selective PTP1B inhibitor
GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2
GC16256 BVT 948
4-羟基-3,3-二甲基-2H-苯并[G]吲哚-2,5(3H)-二酮
An inhibitor of protein tyrosine phosphatases
GC17344 Alexidine dihydrochloride
己联双辛胍二盐酸盐
An alkyl bis(biguanide) antiseptic
GC14321 Sal 003
(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺
An inhibitor of eIF2α dephosphorylation
GC16958 Okadaic acid
冈田酸

A potent inhibitor of protein phosphatases
GC17966 NFAT Inhibitor
VIVIT peptide
A peptide inhibitor of NFAT
GC16117 INCA-6
Triptycene-1,4-quinone
A cell-permeant inhibitor of NFAT signaling
GC12604 Fumonisin B1
伏马菌素B1

A mycotoxin
GC14395 Fostriecin sodium salt
福司曲星
A potent inhibitor of protein phosphatases 2A and 4
GC14024 DL-AP3
DL-2-氨基-3-磷丙酸
A metabotropic glutamate receptor antagonist
GC17011 C2 Ceramide
N-乙酰基神经鞘氨醇,C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine
C2 Ceramide是一种短链细胞渗透性神经酰胺类似物，可抑制Bcl2蛋白的磷酸化，IC₅₀值为14μmol/L。
GC18106 Calyculin A
蛋白磷酸酯酶抑制剂,(-)-Calyculin A

Calyculin A是蛋白磷酸酶1（PP1）和蛋白磷酸酶2A（PP2A）的强效抑制剂, IC₅₀值分别为2nM和0.5–1.0nM。
GC12743 Calcineurin Autoinhibitory Peptide Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂，IC50 为 ~10 μM。