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Protein Ser/Thr Phosphatases(蛋白质丝氨酸/苏氨酸磷酸酶)

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

Products for  Protein Ser/Thr Phosphatases

  1. Cat.No. 产品名称 Information
  2. GC15974 bpV(HOpic) (potassium salt, technical grade) A PTEN inhibitor
  3. GC15969 PTP Inhibitor IV An active-site directed inhibitor of protein tyrosine phosphatases
  4. GC11806 β-Glycerophosphate (sodium salt hydrate)

    An inhibitor of alkaline phosphatase

  5. GC16900 PRL-3 Inhibitor An inhibitor of PTP4A3
  6. GC12082 Cantharidic Acid (sodium salt) A protein phosphatase inhibitor
  7. GC15120 PTP Inhibitor I A SHP-1(ΔSH2) and PTP1B inhibitor
  8. GC15804 PTP Inhibitor II A SHP-1(ΔSH2) inhibitor
  9. GC13442 Sanguinarine chloride A natural alkaloid with anti-inflammatory and anti-oxidant properties
  10. GC12498 Sephin1 A selective inhibitor of the phosphatase regulatory subunit PPP1R15A
  11. GC12189 LB-100 A PP2A inhibitor with anticancer activity
  12. GC11561 NSC 95397 An irreversible inhibitor of Cdc25 isoforms
  13. GC11381 Tautomycetin

    Tautomycetin 是一种有效的特异性 PP1 抑制剂,具有潜在的细胞凋亡诱导活性。

  14. GC14875 NSC 663284 Inhibitor of Cdc25 isoforms
  15. GC16290 Nafamostat hydrochloride Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂,是一种抗凝剂。
  16. GC17676 Nafamostat A serine protease inhibitor
  17. GC12891 CCT007093 An inhibitor of PPM1D
  18. GC15718 CID 2011756 An inhibitor of protein kinase D
  19. GC12020 TCS 401 A selective PTP1B inhibitor
  20. GC10169 NSC 87877 A potent inhibitor of SHP-1 and SHP-2
  21. GC16256 BVT 948 An inhibitor of protein tyrosine phosphatases
  22. GC17344 Alexidine dihydrochloride An alkyl bis(biguanide) antiseptic
  23. GC14321 Sal 003 An inhibitor of eIF2α dephosphorylation
  24. GC16958 Okadaic acid A potent inhibitor of protein phosphatases
  25. GC17966 NFAT Inhibitor A peptide inhibitor of NFAT
  26. GC16117 INCA-6 A cell-permeant inhibitor of NFAT signaling
  27. GC12604 Fumonisin B1

    A mycotoxin

  28. GC14395 Fostriecin sodium salt A potent inhibitor of protein phosphatases 2A and 4
  29. GC14024 DL-AP3 A metabotropic glutamate receptor antagonist
  30. GC17011 C2 Ceramide A cell-permeable analog of naturally occurring ceramides
  31. GC18106 Calyculin A Potent inhibitor of PP1 and PP2A
  32. GC12743 Calcineurin Autoinhibitory Peptide Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂,IC50 为 ~10 μM。

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