Sirtuin(Sirtuin蛋白)
Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.
Products for Sirtuin
- Cat.No. 产品名称 Information
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GC69950
SRT 1720 dihydrochloride
SRT 1720 dihydrochloride 是选择性的和具有口服活性的 SIRT1 激活剂,EC50 为 0.10 μM,对 SIRT2 和 SIRT3 的作用较弱。
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GC69898
SIRT5 inhibitor 3
SIRT5 inhibitor 3 (compound 46) 是一种有效且具有竞争性的 SIRT5 抑制剂,IC50 为 5.9 μM。SIRT5 inhibitor 3 可抑制 SIRT5 去乙酰化。SIRT5 inhibitor 3 可用于癌症和神经退行性疾病的研究。
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GC69897
SIRT1-IN-2
SIRT1-IN-2 (compound 3h) 是一种有效且选择性的 SIRT1 (沉默信息调节因子1)抑制剂,其IC50 为 1.6 μM。
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GC69033
E1231
1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
E1231 是一种具有口服有效的 Sirtuin 1 (SIRT1) (EC50=0.83 μM) 激活剂,可调节胆固醇和脂质代谢。E1231 与 SIRT1 和脱乙酰肝 X 受体-α (LXRα) 相互作用,并增加 ATP 结合盒转运蛋白 A1 (ABCA1) 的表达。E1231 还可以减少 ApoE-/- 小鼠模型中动脉粥样硬化斑块的形成。E1231 可用于胆固醇和脂质紊乱相关疾病的研究。 -
GC68900
CrBKA
CrBKA 是 SIRT6 的弱活性荧光小分子底物。
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GC67778
Sirtuin modulator 3
Sirtuin modulator 3 (compound 129) 是一种 N -苯基苯甲酰胺衍生物,作为 Sirtuin 调制剂。
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GC66026
SIRT2-IN-9
SIRT2-IN-9 (compound 12) 是 SRIT2 的选择性抑制剂,IC50 值为 1.3 μM。SIRT2-IN-9 抑制 MCF-7 乳腺癌细胞的增殖活性。SIRT2-IN-9 可用于癌症的研究。
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GC65581
MIND4-19
MIND4-19 是一种有效的 SIRT2 抑制剂,IC50 为 7.0 μM。MIND4-19 可用于亨廷顿氏舞蹈症 (Huntington's disease) 的研究。
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GC65030
Sirtuin modulator 2
Sirtuin modulator 2 (Compound 132) 是一种 sirtuin 调节剂,ED50 不超过 50 μM。
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GC65019
SRT 1460
3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-B]噻唑-6-基)苯基)苯甲酰胺
SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis. -
GC64946
SRT 2183
SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
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GC64575
Et-29
Et-29 是一种有效的,选择性的 SIRT5 抑制剂 (Ki=40 nM)。
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GC64527
ADTL-SA1215
ADTL-SA1215 是一种调节三阴性乳腺癌自噬的特异性 SIRT3 小分子激活剂。
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GC64255
CHIC35
CHIC35 是 EX-527 的结构类似物,是 SIRT1 (IC50=0.124 µM) 的有效选择性抑制剂。CHIC35 对 SIRT1 的选择性远大于对 SIRT2 (IC50=2.8 µM) 和 SIRT3 (IC50>100 µM)。CHIC35 具有抗炎作用,可用于 CHARGE 综合征的研究。
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GC62886
Cannabisin F
大麻酰胺F
Cannabisin F 是一种 SIRT1 调制器。Cannabisin F 作为大麻籽木素酰胺,可用于抗炎、抗氧化研究。Cannabisin F 作为SIRT1/NF-κB 和 Nrf2 的调节因子,可能是一种潜在的神经退行性疾病的调节剂。 -
GC62651
7-Chloro-4-(piperazin-1-yl)quinoline
7-氯-4-(1-哌嗪基)喹啉
7-Chloro-4-(piperazin-1-yl)quinolone 是药物化学中的重要支架。7-Chloro-4-(piperazin-1-yl)quinolone 是有效的 sirtuin 抑制剂,还抑制 5-羟色胺的摄取 (IC50 为 50 μM)。7-Chloro-4-(piperazin-1-yl)quinolone 对恶性疟原虫 D10 和 K1 菌株表现出抗疟疾活性,IC50 分别为 1.18 μM 和 0.97 μM。 -
GC61279
SIRT-IN-3
2-(苯基氨基)苯甲酰胺
SIRT-IN-3是一种有效的SIRT抑制剂,对SIRT1的IC50为17μM。SIRT-IN-3对SIRT1的选择性分别是SIRT-2和SIRT3的4倍和14倍(IC50forSIRT2=74μM;IC50forSIRT3=235μM)。 -
GC60172
Gardenia yellow
西红花苷 I
Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice. -
GC39435
Scopolin
东莨菪苷
A coumarin glucoside with anti-inflammatory activity -
GC37761
Tenovin-6 Hydrochloride
A small molecule activator of p53
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GC37677
SRT 1720
N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-喹喔啉甲酰胺
A selective, potent SIRT1 activator -
GC36738
Nicotinamide riboside chloride
烟酰胺核糖氯酸盐
A riboside form of nicotinamide -
GC44401
Nicotinamide riboside
烟酰胺核糖
A riboside form of nicotinamide
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GC40900
Ganoderic Acid D
灵芝酸 D
An oxygenated triterpenoid -
GC34849
UBCS039
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
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GC34785
Sirt2-IN-1
Sirt2-IN-1(Compound9)是一种sirtuin2(Sirt2)抑制剂,IC50为163nM。
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GC34431
MC3482
MC3482是一种特异性sirtuin5(SIRT5)抑制剂。
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GC34187
Dihydrocoumarin (Hydrocoumarin)
二氢香豆素; Hydrocoumarin; Chroman-2-one
A coumarin with enzyme inhibitory activity -
GC33418
PROTAC Sirt2 Degrader-1
PROTACSirt2Degrader-1是一种基于SirReal的PROTAC,为Sirt2的降解剂,由一个高效、同种型选择性的Sirt2抑制剂,一个连接物和thalidomide(E3泛素化连接酶的配体)组成。PROTACSirt2Degrader-1对Sirt2的IC50值为0.25μM,而对Sirt1/Sirt3(IC50>100μM)无作用
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GC32745
OSS_128167
OSS_128167 is a potent selective silencing regulatory protein 6 (SIRT6) inhibitor with an IC50 of 89 μM. OSS_128167 can inhibit HBV transcription and replication, and has antiviral and anti-inflammatory effects.
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GC30922
SIRT2 Inhibitor II (AK-1)
A SIRT2 inhibitor
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GC30733
SIRT-IN-1
SIRT-IN-1是SIRT1/2/3的有效抑制剂,其IC50值分别为15,10,33μM。
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GC30693
SIRT-IN-2
SIRT-IN-2是SIRT1/2/3的有效抑制剂,其IC50值分别为4,1,7nM。
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GC30251
SIRT5 inhibitor
SIRT5 inhibitor 是一种有效的 Human Sirtuin 5 deacylase 抑制剂,IC50 为 0.11 μM.
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GC30204
Sirtuin modulator 1
A SIRT1 activator
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GC19013
3-TYP
吡啶-3-乙炔
A SIRT3 inhibitor -
GC18228
CAY10602
1-(4-氟苯基)-3-(苯磺酰基)-1H-吡咯并[2,3-B]喹喔啉-2-胺
A SIRT1 activator -
GC17724
Thiomyristoyl
TM
A potent and selective SIRT2 inhibitor -
GC15931
AGK7
SIRT2 Inhibitor (Inactive Control)
An inactive control for AGK2 -
GC14686
JFD00244
BML-266
An inhibitor of SIRT2 -
GC11716
SIRT1/2 Inhibitor IV
Cambinol,NSC 112546,SIRT1 Inhibitor II,SIRT2 Inhibitor VI
Cell-permeable inhibitor of SIRT1 and SIRT2 -
GC13062
JGB1741
ILS-JGB-1741
A SIRT1 inhibitor -
GC17922
4'-bromo-Resveratrol
5-[(E)-2-(4-溴苯基)乙烯基]间苯二酚,4′‐BR
A potent inhibitor of SIRT1 and SIRT3 -
GC13942
SirReal2
乙酰胺,2-[(4,6-二甲基-2-嘧啶基)硫]-N-[5-(1-萘甲基)-2-噻唑]-
A selective SIRT2 inhibitor -
GC17704
Triacetyl Resveratrol
三乙酰基白藜芦醇
A resveratrol derivative with diverse biological activities -
GC17126
EX-527 R-enantiomer
(R)-EX-527
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。 -
GC13417
EX-527 S-enantiomer
(1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺,(S)-EX-527
EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。 -
GC14817
Salermide
A sirtuin inhibitor
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GC17881
AGK 2
2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺
AGK2 is a selective SIRT2 inhibitor, with an IC50 of 3. -
GC10676
AK-7
N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
An inhibitor of SIRT2