Sirtuin(Sirtuin蛋白)
Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.
- Cat.No. 产品名称 Information
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GC67778
Sirtuin modulator 3
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GC66026
SIRT2-IN-9
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GC65581
MIND4-19
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GC65030
Sirtuin modulator 2
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GC65019
SRT 1460
SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
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GC64946
SRT 2183
SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
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GC64575
Et-29
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GC64527
ADTL-SA1215
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GC64255
CHIC35
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GC62886
Cannabisin F
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GC62651
7-Chloro-4-(piperazin-1-yl)quinoline
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GC61279
SIRT-IN-3
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GC60172
Gardenia yellow
Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice.
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GC39435
Scopolin
A coumarin glucoside with anti-inflammatory activity
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GC37761
Tenovin-6 Hydrochloride
A small molecule activator of p53
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GC37677
SRT 1720
A selective, potent SIRT1 activator
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GC36738
Nicotinamide riboside chloride
A riboside form of nicotinamide
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GC44401
Nicotinamide riboside
A riboside form of nicotinamide
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GC40900
Ganoderic Acid D
An oxygenated triterpenoid
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GC34849
UBCS039
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
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GC34785
Sirt2-IN-1
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GC34431
MC3482
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GC34187
Dihydrocoumarin (Hydrocoumarin)
A coumarin with enzyme inhibitory activity
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GC33418
PROTAC Sirt2 Degrader-1
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GC32745
OSS_128167
A SIRT6 inhibitor
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GC30922
SIRT2 Inhibitor II (AK-1)
A SIRT2 inhibitor
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GC30733
SIRT-IN-1
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GC30693
SIRT-IN-2
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GC30251
SIRT5 inhibitor
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GC30204
Sirtuin modulator 1
A SIRT1 activator
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GC19013
3-TYP
A SIRT3 inhibitor
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GC18228
CAY10602
A SIRT1 activator
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GC17724
Thiomyristoyl
A potent and selective SIRT2 inhibitor
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GC15931
AGK7
An inactive control for AGK2
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GC14686
JFD00244
An inhibitor of SIRT2
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GC11716
SIRT1/2 Inhibitor IV
Cell-permeable inhibitor of SIRT1 and SIRT2
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GC13062
JGB1741
A SIRT1 inhibitor
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GC17922
4'-bromo-Resveratrol
A potent inhibitor of SIRT1 and SIRT3
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GC13942
SirReal2
A selective SIRT2 inhibitor
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GC17704
Triacetyl Resveratrol
A resveratrol derivative with diverse biological activities
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GC17126
EX-527 R-enantiomer
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。
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GC13417
EX-527 S-enantiomer
EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。
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GC14817
Salermide
A sirtuin inhibitor
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GC17881
AGK 2
Inhibitor of SIRT2
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GC10676
AK-7
An inhibitor of SIRT2
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GC14755
Inauhzin
A selective SIRT1 inhibitor
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GC12337
Tenovin-3
A small molecule activator of p53
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GC16436
Tenovin-6
A small molecule activator of p53
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GC10555
Splitomicin
Inhibitor of yeast Sir2p
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GC15109
SRT2104 (GSK2245840)
SRT2104 (GSK2245840) is a highly selective small-molecule activator of Sirtuin 1 (SIRT1).