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Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

  1. Cat.No. 产品名称 Information
  2. GC67778 Sirtuin modulator 3
  3. GC66026 SIRT2-IN-9
  4. GC65581 MIND4-19
  5. GC65030 Sirtuin modulator 2
  6. GC65019 SRT 1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
  7. GC64946 SRT 2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
  8. GC64575 Et-29
  9. GC64527 ADTL-SA1215
  10. GC64255 CHIC35
  11. GC62886 Cannabisin F
  12. GC62651 7-Chloro-4-(piperazin-1-yl)quinoline
  13. GC61279 SIRT-IN-3
  14. GC60172 Gardenia yellow Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice.
  15. GC39435 Scopolin A coumarin glucoside with anti-inflammatory activity
  16. GC37761 Tenovin-6 Hydrochloride A small molecule activator of p53
  17. GC37677 SRT 1720 A selective, potent SIRT1 activator
  18. GC36738 Nicotinamide riboside chloride A riboside form of nicotinamide
  19. GC44401 Nicotinamide riboside A riboside form of nicotinamide
  20. GC40900 Ganoderic Acid D An oxygenated triterpenoid
  21. GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
  22. GC34785 Sirt2-IN-1
  23. GC34431 MC3482
  24. GC34187 Dihydrocoumarin (Hydrocoumarin) A coumarin with enzyme inhibitory activity
  25. GC33418 PROTAC Sirt2 Degrader-1
  26. GC32745 OSS_128167 A SIRT6 inhibitor
  27. GC30922 SIRT2 Inhibitor II (AK-1) A SIRT2 inhibitor
  28. GC30733 SIRT-IN-1
  29. GC30693 SIRT-IN-2
  30. GC30251 SIRT5 inhibitor
  31. GC30204 Sirtuin modulator 1 A SIRT1 activator
  32. GC19013 3-TYP A SIRT3 inhibitor
  33. GC18228 CAY10602 A SIRT1 activator
  34. GC17724 Thiomyristoyl A potent and selective SIRT2 inhibitor
  35. GC15931 AGK7 An inactive control for AGK2
  36. GC14686 JFD00244 An inhibitor of SIRT2
  37. GC11716 SIRT1/2 Inhibitor IV Cell-permeable inhibitor of SIRT1 and SIRT2
  38. GC13062 JGB1741 A SIRT1 inhibitor
  39. GC17922 4'-bromo-Resveratrol A potent inhibitor of SIRT1 and SIRT3
  40. GC13942 SirReal2 A selective SIRT2 inhibitor
  41. GC17704 Triacetyl Resveratrol A resveratrol derivative with diverse biological activities
  42. GC17126 EX-527 R-enantiomer EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。
  43. GC13417 EX-527 S-enantiomer EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂,IC50 为 98 nM。
  44. GC14817 Salermide A sirtuin inhibitor
  45. GC17881 AGK 2 Inhibitor of SIRT2
  46. GC10676 AK-7 An inhibitor of SIRT2
  47. GC14755 Inauhzin A selective SIRT1 inhibitor
  48. GC12337 Tenovin-3 A small molecule activator of p53
  49. GC16436 Tenovin-6 A small molecule activator of p53
  50. GC10555 Splitomicin Inhibitor of yeast Sir2p
  51. GC15109 SRT2104 (GSK2245840)

    SRT2104 (GSK2245840) is a highly selective small-molecule activator of Sirtuin 1 (SIRT1).

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