Sirtuin(Sirtuin蛋白)

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

Cat.No. 产品名称 Information
GC67778 Sirtuin modulator 3
GC66026 SIRT2-IN-9
GC65581 MIND4-19
GC65030 Sirtuin modulator 2
GC65019 SRT 1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
GC64946 SRT 2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
GC64575 Et-29
GC64527 ADTL-SA1215
GC64255 CHIC35
GC62886 Cannabisin F
GC62651 7-Chloro-4-(piperazin-1-yl)quinoline
GC61279 SIRT-IN-3
GC60172 Gardenia yellow Crocin-I, a major member of the crocin family, has antidepressant activity and ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice.
GC39435 Scopolin A coumarin glucoside with anti-inflammatory activity
GC37761 Tenovin-6 Hydrochloride A small molecule activator of p53
GC37677 SRT 1720 A selective, potent SIRT1 activator
GC36738 Nicotinamide riboside chloride A riboside form of nicotinamide
GC44401 Nicotinamide riboside A riboside form of nicotinamide
GC40900 Ganoderic Acid D An oxygenated triterpenoid
GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
GC34785 Sirt2-IN-1
GC34431 MC3482
GC34187 Dihydrocoumarin (Hydrocoumarin) A coumarin with enzyme inhibitory activity
GC33418 PROTAC Sirt2 Degrader-1
GC32745 OSS_128167 A SIRT6 inhibitor
GC30922 SIRT2 Inhibitor II (AK-1) A SIRT2 inhibitor
GC30733 SIRT-IN-1
GC30693 SIRT-IN-2
GC30251 SIRT5 inhibitor
GC30204 Sirtuin modulator 1 A SIRT1 activator
GC19013 3-TYP A SIRT3 inhibitor
GC18228 CAY10602 A SIRT1 activator
GC17724 Thiomyristoyl A potent and selective SIRT2 inhibitor
GC15931 AGK7 An inactive control for AGK2
GC14686 JFD00244 An inhibitor of SIRT2
GC11716 SIRT1/2 Inhibitor IV Cell-permeable inhibitor of SIRT1 and SIRT2
GC13062 JGB1741 A SIRT1 inhibitor
GC17922 4'-bromo-Resveratrol A potent inhibitor of SIRT1 and SIRT3
GC13942 SirReal2 A selective SIRT2 inhibitor
GC17704 Triacetyl Resveratrol A resveratrol derivative with diverse biological activities
GC17126 EX-527 R-enantiomer EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
GC13417 EX-527 S-enantiomer EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
GC14817 Salermide A sirtuin inhibitor
GC17881 AGK 2 Inhibitor of SIRT2
GC10676 AK-7 An inhibitor of SIRT2
GC14755 Inauhzin A selective SIRT1 inhibitor
GC12337 Tenovin-3 A small molecule activator of p53
GC16436 Tenovin-6 A small molecule activator of p53
GC10555 Splitomicin Inhibitor of yeast Sir2p
GC15109 SRT2104 (GSK2245840)
SRT2104 (GSK2245840) is a highly selective small-molecule activator of Sirtuin 1 (SIRT1).