AMPK(AMP活化蛋白激酶)
AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.
- Cat.No. 产品名称 Information
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GC25648
MOTS-c
MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
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GC67961
AMPK-IN-3
AMPK-IN-3 (化合物 67) 是一种强效的、选择性的 AMPK 抑制剂,其对AMPK (α2)、AMPK (α1) 和 KDR 的 IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 对 AMPK 的抑制不影响细胞活力或导致 K562 细胞的明显细胞毒性。AMPK-IN-3 可用于癌症的研究。
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GC67772
BAY-3827
BAY-3827 是强效的、选择性的 AMPK 抑制剂,IC50 值为 1.4 nM (10 µM ATP) 和 15 nM (2 mM ATP)。BAY-3827 对其他 331 种被测激酶的选择性超过 500 倍相比于 AMPK。AMPK 抑制乙酰 CoA 羧化酶 1 的磷酸化,并在雄激素依赖的前列腺癌细胞株中显示出强效的抗增殖活性。
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GC66024
Aldometanib
Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。
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GC66002
PF-06685249
PF-06685249 (PF-249) 是一种有效的、具有口服活性的变构 AMPK 激活剂,对重组 AMPK α1β1γ1 的 EC50 为 12 nM。PF-06685249 可用于糖尿病肾病研究。
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GC63934
Karanjin
Karanjin 是 Fordia cauliflora 中主要的活性呋喃黄酮醇成分。Karanjin 通过提高 AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。Karanjin 可通过细胞周期阻滞诱导癌细胞死亡,促进细胞凋亡。
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GC62841
AMPK activator 4
AMPK activator 4 是一种有效 AMPK 激活剂,并且不抑制线粒体复合物 I。AMPK activator 4 选择性地激活肌肉组织中的 AMPK。AMPK activator 4 剂量依赖性地改善正常小鼠的糖耐量,显著降低 db/db 糖尿病小鼠的空腹血糖水平和改善胰岛素抵抗。具有降血糖作用。
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GC62548
COH-SR4
COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.
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GC62135
BC1618
An inhibitor of FBXO48
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GC61855
Galegine hydrochloride
Galegine hydrochloride, 一种胍衍生物,有助于小鼠减轻体重。胍类是从 G. officinalis 中提取的化合物,产生双胍、二甲双胍和苯甲双胍。Galegine hydrochloride 激活 3T3-L1 脂肪细胞、L6 肌管、H4IIE 大鼠肝癌和 HEK293 人肾细胞系中的 AMPK。Galegine hydrochloride 具有抗菌活性,对金黄色葡萄球菌菌株 (Staphylococcus aureus) 的最低抑菌浓度为 4 mg/L。
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GC61382
Xanthoangelol
Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
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GC61045
Metformin D6 hydrochloride
An internal standard for the quantification of metformin
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GC61029
Marein
A glucoside chalcone with diverse biological activities
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GC60258
MT 63-78
MT 63-78 是一种有效的直接 AMPK 激活剂,EC50 为 25 μM。M 63-78 还诱导细胞有丝分裂阻滞和细胞凋亡 (apoptosis)。MT 63-78 通过抑制脂肪生成和 mTORC1 途径来阻止前列腺癌的生长。MT 63-78 具有抗肿瘤作用。
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GC60245
Metformin
二甲双胍(Metformin 1,1-二甲基双胍)主要介导AMPK的激活,AMPK是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶,导致癌细胞mTOR信号和蛋白质合成的减少。
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GC39377
EB-3D
EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
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GC38815
Methyl cinnamate
Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
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GC38679
Urolithin B
A metabolite of ellagic acid
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GC38567
Nepodin
A naphthol with diverse biological activities
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GC38422
Euphorbiasteroid
A tricyclic diterpene
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GC38209
Kahweol
A natural diterpene with anti-inflammatory and antiangiogenic properties
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GC38101
Demethyleneberberine
Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.
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GC37970
ZLN024
An allosteric activator of AMPK
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GC37694
STO-609
A CaMKK inhibitor
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GC36178
Gomisin J
A lignan with diverse biological activities
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GC35327
AMPK activator 1
AMPK activator 1 是一种代表性的 AMPK 激活剂,EC50<0.1 μM。详细信息请参考专利文献 WO2013116491A1 中的化合物 No.1-75。
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GC35124
3α-Hydroxymogrol
3α-Hydroxymogrol 是从罗汉果中得到的三萜类化合物,为有效的 AMPK 激活剂,可增强 AMPK 的磷酸化水平。
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GC42987
Buformin (hydrochloride)
An antihyperglycemic biguanide
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GC42776
Amarogentin
A secoiridoid glycoside with diverse biological activities
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GC33765
Palmitelaidic Acid (9-trans-Hexadecenoic acid)
A dietary fatty acid
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GC31470
MK8722
MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
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GC31411
EX229
An AMPK activator
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GC31383
Chitosan oligosaccharide COS
Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
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GC31361
MK-3903
An AMPK activator
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GC31348
7-Methoxyisoflavone
A synthetic isoflavone
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GC30056
Danthron (Dantron)
Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
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GC19286
PF-06409577
An AMPK activator
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GC19269
O-304
A pan-activator of AMPK
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GC18208
YLF-466D
An AMPK activator
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GC13992
3-Guanidinopropionic Acid
A creatine analog
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GC11190
AMPK activator
A cell-permeable activator of AMPK
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GC16534
Ampkinone
A small molecule activator of AMPK
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GC11724
GSK621
An AMPK activator
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GC12162
ZLN024 hydrochloride
An allosteric activator of AMPK
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GC13185
HTH-01-015
A selective NUAK1 inhibitor
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GC12324
RSVA 405
RSVA 405 是一种有效的口服活性 AMPK 激活剂,EC50 为 1 μM。
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GC17204
PT 1
An activator of AMPK
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GC12364
SAMS Peptide
A specific substrate for AMPK
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GC13466
Flufenamic acid
An NSAID and COX inhibitor
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GC17443
Metformin HCl
A biguanide with diverse biological activities