AMPK(AMP活化蛋白激酶)
AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.
- Cat.No. 产品名称 Information
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GC25648
MOTS-c
MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
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GC67961
AMPK-IN-3
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GC67772
BAY-3827
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GC66024
Aldometanib
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GC66002
PF-06685249
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GC63934
Karanjin
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GC62841
AMPK activator 4
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GC62548
COH-SR4
COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.
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GC62135
BC1618
An inhibitor of FBXO48
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GC61855
Galegine hydrochloride
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GC61382
Xanthoangelol
Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
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GC61045
Metformin D6 hydrochloride
An internal standard for the quantification of metformin
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GC61029
Marein
A glucoside chalcone with diverse biological activities
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GC60258
MT 63-78
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GC60245
Metformin
二甲双胍(Metformin 1,1-二甲基双胍)主要介导AMPK的激活,AMPK是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶,导致癌细胞mTOR信号和蛋白质合成的减少。
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GC39377
EB-3D
EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
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GC38815
Methyl cinnamate
Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
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GC38679
Urolithin B
A metabolite of ellagic acid
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GC38567
Nepodin
A naphthol with diverse biological activities
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GC38422
Euphorbiasteroid
A tricyclic diterpene
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GC38209
Kahweol
A natural diterpene with anti-inflammatory and antiangiogenic properties
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GC38101
Demethyleneberberine
Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.
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GC37970
ZLN024
An allosteric activator of AMPK
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GC37694
STO-609
A CaMKK inhibitor
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GC36178
Gomisin J
A lignan with diverse biological activities
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GC35327
AMPK activator 1
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GC35124
3α-Hydroxymogrol
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GC42987
Buformin (hydrochloride)
An antihyperglycemic biguanide
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GC42776
Amarogentin
A secoiridoid glycoside with diverse biological activities
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GC33765
Palmitelaidic Acid (9-trans-Hexadecenoic acid)
A dietary fatty acid
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GC31470
MK8722
MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
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GC31411
EX229
An AMPK activator
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GC31383
Chitosan oligosaccharide COS
Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
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GC31361
MK-3903
An AMPK activator
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GC31348
7-Methoxyisoflavone
A synthetic isoflavone
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GC30056
Danthron (Dantron)
Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
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GC19286
PF-06409577
An AMPK activator
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GC19269
O-304
A pan-activator of AMPK
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GC18208
YLF-466D
An AMPK activator
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GC13992
3-Guanidinopropionic Acid
A creatine analog
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GC11190
AMPK activator
A cell-permeable activator of AMPK
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GC16534
Ampkinone
A small molecule activator of AMPK
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GC11724
GSK621
An AMPK activator
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GC12162
ZLN024 hydrochloride
An allosteric activator of AMPK
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GC13185
HTH-01-015
A selective NUAK1 inhibitor
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GC12324
RSVA 405
RSVA 405 是一种有效的口服活性 AMPK 激活剂,EC50 为 1 μM。
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GC17204
PT 1
An activator of AMPK
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GC12364
SAMS Peptide
A specific substrate for AMPK
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GC13466
Flufenamic acid
An NSAID and COX inhibitor
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GC17443
Metformin HCl
A biguanide with diverse biological activities