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AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.

Products for  AMPK

  1. Cat.No. 产品名称 Information
  2. GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
  3. GC67961 AMPK-IN-3 AMPK-IN-3 (化合物 67) 是一种强效的、选择性的 AMPK 抑制剂,其对AMPK (α2)、AMPK (α1) 和 KDR 的 IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 对 AMPK 的抑制不影响细胞活力或导致 K562 细胞的明显细胞毒性。AMPK-IN-3 可用于癌症的研究。
  4. GC67772 BAY-3827 BAY-3827 是强效的、选择性的 AMPK 抑制剂,IC50 值为 1.4 nM (10 µM ATP) 和 15 nM (2 mM ATP)。BAY-3827 对其他 331 种被测激酶的选择性超过 500 倍相比于 AMPK。AMPK 抑制乙酰 CoA 羧化酶 1 的磷酸化,并在雄激素依赖的前列腺癌细胞株中显示出强效的抗增殖活性。
  5. GC66024 Aldometanib

    Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。

  6. GC66002 PF-06685249 PF-06685249 (PF-249) 是一种有效的、具有口服活性的变构 AMPK 激活剂,对重组 AMPK α1β1γ1 的 EC50 为 12 nM。PF-06685249 可用于糖尿病肾病研究。
  7. GC63934 Karanjin Karanjin 是 Fordia cauliflora 中主要的活性呋喃黄酮醇成分。Karanjin 通过提高 AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。Karanjin 可通过细胞周期阻滞诱导癌细胞死亡,促进细胞凋亡。
  8. GC62841 AMPK activator 4 AMPK activator 4 是一种有效 AMPK 激活剂,并且不抑制线粒体复合物 I。AMPK activator 4 选择性地激活肌肉组织中的 AMPK。AMPK activator 4 剂量依赖性地改善正常小鼠的糖耐量,显著降低 db/db 糖尿病小鼠的空腹血糖水平和改善胰岛素抵抗。具有降血糖作用。
  9. GC62548 COH-SR4 COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.
  10. GC62135 BC1618 An inhibitor of FBXO48
  11. GC61855 Galegine hydrochloride

    Galegine hydrochloride, 一种胍衍生物,有助于小鼠减轻体重。胍类是从 G. officinalis 中提取的化合物,产生双胍、二甲双胍和苯甲双胍。Galegine hydrochloride 激活 3T3-L1 脂肪细胞、L6 肌管、H4IIE 大鼠肝癌和 HEK293 人肾细胞系中的 AMPK。Galegine hydrochloride 具有抗菌活性,对金黄色葡萄球菌菌株 (Staphylococcus aureus) 的最低抑菌浓度为 4 mg/L。

  12. GC61382 Xanthoangelol Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
  13. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
  14. GC61029 Marein A glucoside chalcone with diverse biological activities
  15. GC60258 MT 63-78 MT 63-78 是一种有效的直接 AMPK 激活剂,EC50 为 25 μM。M 63-78 还诱导细胞有丝分裂阻滞和细胞凋亡 (apoptosis)。MT 63-78 通过抑制脂肪生成和 mTORC1 途径来阻止前列腺癌的生长。MT 63-78 具有抗肿瘤作用。
  16. GC60245 Metformin

    二甲双胍(Metformin 1,1-二甲基双胍)主要介导AMPK的激活,AMPK是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶,导致癌细胞mTOR信号和蛋白质合成的减少。

  17. GC39377 EB-3D EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
  18. GC38815 Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
  19. GC38679 Urolithin B A metabolite of ellagic acid
  20. GC38567 Nepodin A naphthol with diverse biological activities
  21. GC38422 Euphorbiasteroid A tricyclic diterpene
  22. GC38209 Kahweol A natural diterpene with anti-inflammatory and antiangiogenic properties
  23. GC38101 Demethyleneberberine

    Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.

  24. GC37970 ZLN024 An allosteric activator of AMPK
  25. GC37694 STO-609 A CaMKK inhibitor
  26. GC36178 Gomisin J A lignan with diverse biological activities
  27. GC35327 AMPK activator 1 AMPK activator 1 是一种代表性的 AMPK 激活剂,EC50<0.1 μM。详细信息请参考专利文献 WO2013116491A1 中的化合物 No.1-75。
  28. GC35124 3α-Hydroxymogrol 3α-Hydroxymogrol 是从罗汉果中得到的三萜类化合物,为有效的 AMPK 激活剂,可增强 AMPK 的磷酸化水平。
  29. GC42987 Buformin (hydrochloride) An antihyperglycemic biguanide
  30. GC42776 Amarogentin A secoiridoid glycoside with diverse biological activities
  31. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) A dietary fatty acid
  32. GC31470 MK8722 MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
  33. GC31411 EX229 An AMPK activator
  34. GC31383 Chitosan oligosaccharide COS Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
  35. GC31361 MK-3903 An AMPK activator
  36. GC31348 7-Methoxyisoflavone A synthetic isoflavone
  37. GC30056 Danthron (Dantron) Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
  38. GC19286 PF-06409577 An AMPK activator
  39. GC19269 O-304 A pan-activator of AMPK
  40. GC18208 YLF-466D An AMPK activator
  41. GC13992 3-Guanidinopropionic Acid A creatine analog
  42. GC11190 AMPK activator A cell-permeable activator of AMPK
  43. GC16534 Ampkinone A small molecule activator of AMPK
  44. GC11724 GSK621 An AMPK activator
  45. GC12162 ZLN024 hydrochloride An allosteric activator of AMPK
  46. GC13185 HTH-01-015 A selective NUAK1 inhibitor
  47. GC12324 RSVA 405 RSVA 405 是一种有效的口服活性 AMPK 激活剂,EC50 为 1 μM。
  48. GC17204 PT 1 An activator of AMPK
  49. GC12364 SAMS Peptide A specific substrate for AMPK
  50. GC13466 Flufenamic acid An NSAID and COX inhibitor
  51. GC17443 Metformin HCl

    A biguanide with diverse biological activities

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