Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> AMPK


AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.

  1. Cat.No. 产品名称 Information
  2. GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
  3. GC67961 AMPK-IN-3
  4. GC67772 BAY-3827
  5. GC66024 Aldometanib
  6. GC66002 PF-06685249
  7. GC63934 Karanjin
  8. GC62841 AMPK activator 4
  9. GC62548 COH-SR4 COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.
  10. GC62135 BC1618 An inhibitor of FBXO48
  11. GC61855 Galegine hydrochloride
  12. GC61382 Xanthoangelol Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
  13. GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
  14. GC61029 Marein A glucoside chalcone with diverse biological activities
  15. GC60258 MT 63-78
  16. GC60245 Metformin

    二甲双胍(Metformin 1,1-二甲基双胍)主要介导AMPK的激活,AMPK是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶,导致癌细胞mTOR信号和蛋白质合成的减少。

  17. GC39377 EB-3D EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.
  18. GC38815 Methyl cinnamate Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.
  19. GC38679 Urolithin B A metabolite of ellagic acid
  20. GC38567 Nepodin A naphthol with diverse biological activities
  21. GC38422 Euphorbiasteroid A tricyclic diterpene
  22. GC38209 Kahweol A natural diterpene with anti-inflammatory and antiangiogenic properties
  23. GC38101 Demethyleneberberine

    Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity.

  24. GC37970 ZLN024 An allosteric activator of AMPK
  25. GC37694 STO-609 A CaMKK inhibitor
  26. GC36178 Gomisin J A lignan with diverse biological activities
  27. GC35327 AMPK activator 1
  28. GC35124 3α-Hydroxymogrol
  29. GC42987 Buformin (hydrochloride) An antihyperglycemic biguanide
  30. GC42776 Amarogentin A secoiridoid glycoside with diverse biological activities
  31. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) A dietary fatty acid
  32. GC31470 MK8722 MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
  33. GC31411 EX229 An AMPK activator
  34. GC31383 Chitosan oligosaccharide COS Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
  35. GC31361 MK-3903 An AMPK activator
  36. GC31348 7-Methoxyisoflavone A synthetic isoflavone
  37. GC30056 Danthron (Dantron) Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
  38. GC19286 PF-06409577 An AMPK activator
  39. GC19269 O-304 A pan-activator of AMPK
  40. GC18208 YLF-466D An AMPK activator
  41. GC13992 3-Guanidinopropionic Acid A creatine analog
  42. GC11190 AMPK activator A cell-permeable activator of AMPK
  43. GC16534 Ampkinone A small molecule activator of AMPK
  44. GC11724 GSK621 An AMPK activator
  45. GC12162 ZLN024 hydrochloride An allosteric activator of AMPK
  46. GC13185 HTH-01-015 A selective NUAK1 inhibitor
  47. GC12324 RSVA 405 RSVA 405 是一种有效的口服活性 AMPK 激活剂,EC50 为 1 μM。
  48. GC17204 PT 1 An activator of AMPK
  49. GC12364 SAMS Peptide A specific substrate for AMPK
  50. GC13466 Flufenamic acid An NSAID and COX inhibitor
  51. GC17443 Metformin HCl A biguanide with diverse biological activities

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