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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis(其他细胞凋亡)

  1. Cat.No. 产品名称 Information
  2. GC25743 PIM447 (LGH447) PIM447 (LGH447) is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). PIM447 induces apoptosis.
  3. GC25691 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
  4. GC25428 Foscenvivint (ICG-001) Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
  5. GC19771 STM2457 An inhibitor of the METTL3/14 complex
  6. GC39620 AKOS-22
  7. GC50372 SK 216 Plasminogen activator inhibitor-1 (PAI-1) inhibitor
  8. GC50282 EC 19 Synthetic retinoid; induces differentiation of stem cells
  9. GC50223 MSC 2032964A Potent and selective ASK1 inhibitor; orally bioavailable
  10. GC50141 SMBA 1 High affinity and selective activator of Bax
  11. GC50118 S 07662 Constitutive androstane receptor (CAR) inverse agonist
  12. GC50112 NCL 00017509 A Nek2 inhibitor
  13. GC50063 rac-CCT 250863 rac-CCT 250863 (compound rac-21) 是一种选择性和可逆的 NEK 2 抑制剂，IC50 为 0.073 µM。 rac-CCT 250863 表现出良好的诱导细胞周期停滞的作用，并且还可以在细胞中进行抗增殖（Pomalidomide 敏感/抗性）。 rac-CCT 250863 与 Pomalidomide 结合时可诱导细胞凋亡。
  14. GC39182 Soyasaponin III
  15. GC39175 SR-4835 SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
  16. GC39174 EC359
  17. GC39169 CC-92480 A modulator of cereblon
  18. GC39167 VBIT-4 VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.
  19. GC39155 PI-273 PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
  20. GC39152 9-ING-41 A GSK3β inhibitor
  21. GC46027 IP7e An activator of Nurr1 signaling
  22. GC46008 (±)-Thalidomide-d4 An internal standard for the quantification of (±)-thalidomide
  23. GC38864 TL02-59 TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM.
  24. GC38863 TK216 TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.
  25. GC38853 Tandutinib hydrochloride An antagonist of PDGFRβ, FLT3, and c-Kit
  26. GC38848 Se-Methylselenocysteine A selenium-containing amino acid
  27. GC38817 Minerval A synthetic monounsaturated hydroxylated fatty acid
  28. GC38772 DIM-C-pPhOH A Nur77 antagonist
  29. GC45723 Macitentan-d4 An internal standard for the quantification of macitentan
  30. GC38710 TVB-3166 A FASN inhibitor
  31. GC38683 Benzyl isothiocyanate Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.
  32. GC38653 Selumetinib sulfate
  33. GC38620 Dihydrorotenone
  34. GC38617 Dihydrokaempferol A flavone with diverse biological activities
  35. GC38609 Rotundic acid Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
  36. GC38606 Glaucocalyxin A Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
  37. GC38592 PTC596 A BMI1 inhibitor
  38. GC38566 Ilexsaponin A
  39. GC38564 Deoxypodophyllotoxin A flavolignan with diverse biological activities
  40. GC38545 Polygalacin D
  41. GC38467 BTdCPU BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
  42. GC38447 Eriosematin
  43. GC38437 Fangchinoline An alkaloid with diverse biological activities
  44. GC38425 Sophoridine A quinolizidine alkaloid with diverse biological activities
  45. GC38419 Cyclovirobuxine D An alkaloid with diverse biological activities
  46. GC38408 Diosgenin glucoside A steroidal saponin with diverse biological activities
  47. GC38406 MN58b
  48. GC38392 Euscaphic acid A triterpene with diverse biological activities
  49. GC38374 Uvarigrin
  50. GC38318 2-Methoxycinnamaldehyde 2-methoxycinnamaldehyde (O-methoxycinnamaldehyde), found in ceylan cinnamon, is a flavouring ingredient.
  51. GC38237 Higenamine hydrochloride Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.

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