Other Apoptosis(其他细胞凋亡)
- Cat.No. 产品名称 Information
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GC25743
PIM447 (LGH447)
PIM447 (LGH447) is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). PIM447 induces apoptosis.
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GC25691
OTS514 hydrochloride
OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
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GC25428
Foscenvivint (ICG-001)
Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.
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GC19771
STM2457
An inhibitor of the METTL3/14 complex
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GC39620
AKOS-22
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GC50372
SK 216
Plasminogen activator inhibitor-1 (PAI-1) inhibitor
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GC50282
EC 19
Synthetic retinoid; induces differentiation of stem cells
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GC50223
MSC 2032964A
Potent and selective ASK1 inhibitor; orally bioavailable
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GC50141
SMBA 1
High affinity and selective activator of Bax
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GC50118
S 07662
Constitutive androstane receptor (CAR) inverse agonist
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GC50112
NCL 00017509
A Nek2 inhibitor
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GC50063
rac-CCT 250863
rac-CCT 250863 (compound rac-21) 是一种选择性和可逆的 NEK 2 抑制剂,IC50 为 0.073 µM。 rac-CCT 250863 表现出良好的诱导细胞周期停滞的作用,并且还可以在细胞中进行抗增殖(Pomalidomide 敏感/抗性)。 rac-CCT 250863 与 Pomalidomide 结合时可诱导细胞凋亡。
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GC39182
Soyasaponin III
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GC39175
SR-4835
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
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GC39174
EC359
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GC39169
CC-92480
A modulator of cereblon
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GC39167
VBIT-4
VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.
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GC39155
PI-273
PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
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GC39152
9-ING-41
A GSK3β inhibitor
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GC46027
IP7e
An activator of Nurr1 signaling
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GC46008
(±)-Thalidomide-d4
An internal standard for the quantification of (±)-thalidomide
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GC38864
TL02-59
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM.
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GC38863
TK216
TK216 is a potent inhibitor targeting E26 transformation specific (ETS) factors via blocking the protein-protein interaction with RNA helicases. TK216 exhibits antilymphoma activity.
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GC38853
Tandutinib hydrochloride
An antagonist of PDGFRβ, FLT3, and c-
Kit -
GC38848
Se-Methylselenocysteine
A selenium-containing amino acid
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GC38817
Minerval
A synthetic monounsaturated hydroxylated fatty acid
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GC38772
DIM-C-pPhOH
A Nur77 antagonist
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GC45723
Macitentan-d4
An internal standard for the quantification of macitentan
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GC38710
TVB-3166
A FASN inhibitor
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GC38683
Benzyl isothiocyanate
Benzyl isothiocyanate (BITC, Benzoylthiocarbimide, Isothiocyanic Acid Benzoyl Ester) is an isothiocyanate originally found in cruciferous vegetables that exhibits immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.
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GC38653
Selumetinib sulfate
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GC38620
Dihydrorotenone
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GC38617
Dihydrokaempferol
A flavone with diverse biological activities
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GC38609
Rotundic acid
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
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GC38606
Glaucocalyxin A
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
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GC38592
PTC596
A BMI1 inhibitor
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GC38566
Ilexsaponin A
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GC38564
Deoxypodophyllotoxin
A flavolignan with diverse biological activities
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GC38545
Polygalacin D
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GC38467
BTdCPU
BTdCPU is a potent activator of heme regulated inhibitor kinase (HRI), one of eukaryotic translation initiation factor 2α kinases (eIF2α-kinases).
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GC38447
Eriosematin
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GC38437
Fangchinoline
An alkaloid with diverse biological activities
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GC38425
Sophoridine
A quinolizidine alkaloid with diverse biological activities
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GC38419
Cyclovirobuxine D
An alkaloid with diverse biological activities
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GC38408
Diosgenin glucoside
A steroidal saponin with diverse biological activities
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GC38406
MN58b
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GC38392
Euscaphic acid
A triterpene with diverse biological activities
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GC38374
Uvarigrin
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GC38318
2-Methoxycinnamaldehyde
2-methoxycinnamaldehyde (O-methoxycinnamaldehyde), found in ceylan cinnamon, is a flavouring ingredient.
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GC38237
Higenamine hydrochloride
Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.