Home>>Signaling Pathways>> Apoptosis>> Other Apoptosis>>(±)-Thalidomide-d4
(±)-Thalidomide-d4 目录号 GC46008

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1mg
¥1,625.00
现货
5mg
¥6,097.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1219177-18-0 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=C(C1=C2C([2H])=C([2H])C([2H])=C1[2H])N(C3C(NC(CC3)=O)=O)C2=O
分子式 C13H6D4N2O4 分子量 262.3
溶解度 DMF: 12 mg/ml,DMSO: 12 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.11 mg/ml 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

(±)-Thalidomide-d4 is intended for use as an internal standard for the quantification of (±)-thalidomide by GC- or LC-MS. (±)-Thalidomide is an immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC50 = 8.5 nM), a ubiquitously-expressed E3 ligase, and CRBN-DDB1 complexes.1,2

|1. Ito, T., Ando, H., Suzuki, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327(5971), 1345-1350 (2010).|2. Lopez-Girona, A., Mendy, D., Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).