Home >> Signaling Pathways >> Stem Cell >> Wnt/β-catenin


β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

  1. Cat.No. 产品名称 Information
  2. GC25603 M2912 M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.
  3. GC67737 NLS-StAx-h TFA
  4. GC66371 (E)-Ferulic acid-d3
  5. GC66039 Wnt/β-catenin agonist 3
  6. GC65919 NRX-252114
  7. GC65916 NRX-103095
  8. GC65356 KY-02327 acetate
  9. GC65336 NRX-252262
  10. GC65167 Carboxylesterase-IN-3
  11. GC65165 Carboxylesterase-IN-2
  12. GC65066 Prodigiosin hydrochloride A natural red pigment and antibiotic
  13. GC64837 Nefopam D3 hydrochloride
  14. GC64832 NRX-2663
  15. GC64816 Coronaridine
  16. GC63695 Wnt/β-catenin agonist 2
  17. GC63560 ZW4864
  18. GC63559 ZW4864 free base
  19. GC63465 KY-02327
  20. GC63303 YB-0158 YB-0158 被称为 Wnt 通路抑制剂 2。
  21. GC63100 N-Desmethylnefopam D5 hydrochloride
  22. GC62432 β-catenin-IN-2
  23. GC62394 Teplinovivint
  24. GC62214 FIDAS-3 FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.
  25. GC47570 Lipoxygenin An inhibitor of 5-LO
  26. GC50624 FzM1.8 FzM1.8 源自 FzM1,是 FZD4 的变构激动剂,pEC50 为 6.4。 FzM1.8 通过在没有任何 WNT 配体的情况下促进 TCF/LEF 转录活性,与 FZD4 结合并激活 WNT/β-连环蛋白途径。 FzM1.8 结合稳定 FZD4,增加对异源三聚体 G 蛋白的亲和力,并刺激 Gβγ 亚基的释放,进而激活 PI3K。
  27. GC50489 NLS-StAx-h NLS-StAx-h 是一种 Wnt 信号通路的选择性钉合肽抑制剂,IC50 为 1.4 μM。 NLS-StAx-h 有效抑制 β-连环蛋白-转录因子相互作用。 NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。
  28. GC50323 AMBMP hydrochloride AMBMP hydrochloride 是一种有效的细胞渗透性 Wnt 信号激活剂。 BML-284 诱导 TCF 依赖性转录活性,EC50 为 700 nM。
  29. GC50077 WAY 316606 hydrochloride An sFRP-1 inhibitor
  30. GC39266 Hematein Hematein inhibits casein kinase II activity in a selective, dose-dependent and ATP non-competitive manner in vitro, with IC50 of 0.55 μM in the presence of 10 μM ATP.
  31. GC39159 Tegatrabetan Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.
  32. GC46015 KY 05009 A TNIK inhibitor
  33. GC45596 YW1128 An inhibitor of Wnt signaling
  34. GC45354 4β-Hydroxywithanolide E A withanolide with anti-inflammatory and anticancer activities
  35. GC37937 Wnt/β-catenin agonist 1
  36. GC36483 L-Quebrachitol L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
  37. GC36073 Foxy-5 A Wnt5a peptide mimetic
  38. GC35873 DK419
  39. GC34980 (E)-Ferulic acid Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
  40. GC44467 NSC 668036 An inhibitor of the Dvl PDZ domain
  41. GC43725 Gallocyanine A Dkk1 inhibitor
  42. GC42669 ABC99 An inhibitor of NOTUM
  43. GC41534 FzM1 An allosteric ligand of Frizzled4
  44. GC34628 IWP-O1 IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
  45. GC33304 Gigantol
  46. GC32923 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
  47. GC32914 EMT inhibitor-1
  48. GC32763 LF3 An inhibitor of the β-catenin-TCF4 protein-protein interaction
  49. GC32698 Pyrvinium pamoate (Pyrvinium embonate) An anthelmintic and anticancer agent
  50. GC31794 Methyl vanillate

    Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.

  51. GC31717 Ginkgetin A biflavonoid with diverse biological activities

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