Wnt/β-catenin(Wnt/β-连环蛋白)
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
- Cat.No. 产品名称 Information
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GC25603
M2912
M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.
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GC67737
NLS-StAx-h TFA
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GC66371
(E)-Ferulic acid-d3
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GC66039
Wnt/β-catenin agonist 3
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GC65919
NRX-252114
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GC65916
NRX-103095
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GC65356
KY-02327 acetate
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GC65336
NRX-252262
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GC65167
Carboxylesterase-IN-3
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GC65165
Carboxylesterase-IN-2
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GC65066
Prodigiosin hydrochloride
A natural red pigment and antibiotic
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GC64837
Nefopam D3 hydrochloride
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GC64832
NRX-2663
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GC64816
Coronaridine
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GC63695
Wnt/β-catenin agonist 2
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GC63560
ZW4864
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GC63559
ZW4864 free base
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GC63465
KY-02327
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GC63303
YB-0158
YB-0158 被称为 Wnt 通路抑制剂 2。
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GC63100
N-Desmethylnefopam D5 hydrochloride
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GC62432
β-catenin-IN-2
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GC62394
Teplinovivint
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GC62214
FIDAS-3
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.
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GC47570
Lipoxygenin
An inhibitor of 5-LO
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GC50624
FzM1.8
FzM1.8 源自 FzM1,是 FZD4 的变构激动剂,pEC50 为 6.4。 FzM1.8 通过在没有任何 WNT 配体的情况下促进 TCF/LEF 转录活性,与 FZD4 结合并激活 WNT/β-连环蛋白途径。 FzM1.8 结合稳定 FZD4,增加对异源三聚体 G 蛋白的亲和力,并刺激 Gβγ 亚基的释放,进而激活 PI3K。
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GC50489
NLS-StAx-h
NLS-StAx-h 是一种 Wnt 信号通路的选择性钉合肽抑制剂,IC50 为 1.4 μM。 NLS-StAx-h 有效抑制 β-连环蛋白-转录因子相互作用。 NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。
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GC50323
AMBMP hydrochloride
AMBMP hydrochloride 是一种有效的细胞渗透性 Wnt 信号激活剂。 BML-284 诱导 TCF 依赖性转录活性,EC50 为 700 nM。
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GC50077
WAY 316606 hydrochloride
An sFRP-1 inhibitor
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GC39266
Hematein
Hematein inhibits casein kinase II activity in a selective, dose-dependent and ATP non-competitive manner in vitro, with IC50 of 0.55 μM in the presence of 10 μM ATP.
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GC39159
Tegatrabetan
Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.
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GC46015
KY 05009
A TNIK inhibitor
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GC45596
YW1128
An inhibitor of Wnt signaling
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GC45354
4β-Hydroxywithanolide E
A withanolide with anti-inflammatory and anticancer activities
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GC37937
Wnt/β-catenin agonist 1
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GC36483
L-Quebrachitol
L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.
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GC36073
Foxy-5
A Wnt5a peptide mimetic
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GC35873
DK419
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GC34980
(E)-Ferulic acid
Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
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GC44467
NSC 668036
An inhibitor of the Dvl PDZ domain
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GC43725
Gallocyanine
A Dkk1 inhibitor
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GC42669
ABC99
An inhibitor of NOTUM
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GC41534
FzM1
An allosteric ligand of Frizzled4
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GC34628
IWP-O1
IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.
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GC33304
Gigantol
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GC32923
KY1220
KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
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GC32914
EMT inhibitor-1
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GC32763
LF3
An inhibitor of the β-catenin-TCF4 protein-protein interaction
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GC32698
Pyrvinium pamoate (Pyrvinium embonate)
An anthelmintic and anticancer agent
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GC31794
Methyl vanillate
Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.
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GC31717
Ginkgetin
A biflavonoid with diverse biological activities